Mitomycin - Medicines used to treat tumors.
Mitomycin - an antibiotic with anti-tumor action of fungi isolated from Streptomyces caespitosus.
Its structure is similar to mitomycin bruneomitsinom. Preparation of DNA selectively inhibits the growth of cells, a large number it is peculiar to reduce RNA in cells to inhibit protein production, especially in the later stages of mitosis.
Mitomycin imunosupresors has a moderate activity (inhibits the body's defenses).
Mitomycin can buy only in powder form for dilution for intravenous administration and in the various cavities.
Indications for use of mitomycin
Mitomycin effectively in combination with other drugs for chemotherapy, and as an independent means.
Indications for drugs are lung, stomach, pancreatic cancer, esophagus, intestines, liver, colon colon, gall bladder, bladder, breast cancer, cervix, vulva, endometrial, prostate cancer, head and neck.
Also, the instructions given Mitomycin that can be used remedy for mesothelioma, chronic myeloid leukemia and lymphoma.
Buy Mitomycin only by prescription.
Mitomycin should not be applied to cancer patients with severe chronic renal insufficiency during pregnancy, hypersensitivity during lactation.
You can not assign Mitomycin children.
Also, before you buy mitomycin should also know that it is prescribed with caution in infectious diseases, acute bacterial, fungal, viral, in the suppression of bone marrow function (especially in radiation therapy, the use of cytotoxic drugs), coagulopathy.
In appointing the drug simultaneously with doxorubicin should be aware that it could provoke its cardiotoxic effects (may develop congestive heart failure).
Instructions for use of mitomycin
Practice the use of mitomycin in such dosages: 20mg intravenous / square meter. body surface 1p in 4-6ned .; intravenous 2 mg / square meter. for five days a week, therapy lasts for 2 weeks.
The bladder is shown 20-60mg administered funds, dissolved in 20-40ml of saline solution - one p / wk. Therapy lasts 6-8ned.
During the passage of treatment and 7 weeks after the study performed on platelets, hemoglobin, leukocyte, blood cell composition. If the platelet count in the blood contained 150 thousand / cubic mm, leukocytes - 4 th / mm cube or there is a tendency to reduce their level, discontinue use of mitomycin.
Toxic effects of mitomycin on the bone marrow is observed in 60% of cases.
Over 8ned. after initiation of therapy with mitomycin may leukopenia or thrombocytopenia.
The rate figures come only through 10ned after therapy.
At 4% of the toxic effects of mitomycin found on the skin and mucous membranes. Subcutaneous infiltration may appear at the injection site, stomatitis, thrombophlebitis, alopecia (reversible). The rash occurs rarely. When pouring mitomycin into the surrounding tissue can develop their detachment, necrosis.
In 2% of the observed toxic effect of the agent to the kidney. May increase creatinine, develop hematuria, proteinuria.
From the lungs as side effects may develop nonproductive cough, dyspnea, pulmonary infiltrates.
If there are no other reasons for the emergence of side effects of mitomycin instructions supersede and conduct therapy with corticosteroids (dexamethasone, prednisolone, hydrocortisone, etc.).
It is also noted that the combination of mitomycin with other chemotherapeutic agents can cause acute respiratory distress syndrome in adults.
Additional instructions mitomycin indicated that the drug may cause headache, nausea, fever, anorexia, vomiting (during the first one to two hours after dosing), impaired liver function, diarrhea, lung edema, arterial hypertension, diarrhea, cystitis, neurological disorders, atrophy of the bladder.