Miconazole

 Miconazole gel
 Miconazole - an antifungal and anti-inflammatory synthetic drug widely used in gynecology.

Pharmacological action

The active ingredient of the drug - miconazole nitrate, has antifungal and antibacterial effect was less marked in respect of:

  • Trichophyton rubrum;
  • Epidermophyton floccosum;
  • Penicillium crustaceum;
  • Trichophyton mentagrophytes;
  • Malassezia furfur;
  • Candida albicans;
  • Microsporum canis;
  • Aspergillus niger.

The antibacterial effect is more pronounced against staphylococci and streptococci, and less pronounced in respect of Pseudomonas aeruginosa, Escherichia coli, Proteus, and others.

When topically applied miconazole is practically not absorbed into the systemic circulation.

Product form

Miconazole is available in different dosage forms:

  • Miconazole suppositories ("Ginodaktarin") as 0, 1 of 8 or 15 candles in the package;
  • Cream for external use of miconazole, 1 g of cream contains 20 mg of active substance. 15 or 30 g tubes;
  • Tablets containing 250 mg of miconazole nitrate, 10 pieces in a package;
  • Miconazole 1% solution in vials for intravenous injection, 20 ml, 5 vials per pack;
  • Liquids for external use, 1 g of a liquid containing 20 mg of miconazole nitrate, 30 g of Aerosol;
  • Gel for oral administration, 1 g of gel contains 20 mg of active ingredient, 40 g tubes;
  • The alcoholic solution, 1 ml solution contains 20 mg of active ingredient, 30 ml vials with a brush.

Indications application Miconazole

View the disease causes the selection of the dosage form for the treatment of Miconazole:

  • If oropharyngeal candidiasis and intestinal apply miconazole in the form of tablets;
  • When skin diseases caused by fungi sensitive to the active substance, as well as in the secondary infection by Gram-positive microorganisms used miconazole ointment or other dosage forms for topical use;
  • When mucosal candidiasis oral pharynx, mouth and gastrointestinal tract usually prescribe oral gel;
  • When vaginal and vulvovaginal candidiasis, as well as superinfection caused by Gram-positive microorganisms and fungal balanitis used Miconazole suppositories.

Contraindications

Miconazole under the instruction is contraindicated in case of hypersensitivity to the drug, as well as abnormal liver function.

During pregnancy, miconazole is not recommended. During breast-feeding is not recommended to apply miconazole ointment on the breast.

Do not take Miconazole simultaneously with terfenadine, cisapride and astemizolomi.

Instructions for use Miconazole

Dosing, dosing regimen and dosage form Miconazole appointed physician individually depending on the severity and type of disease.

Tablets Miconazole is used for the treatment and prevention of fungal infections of the gastrointestinal tract, four times a day for 120-240 mg. Children over 2 years of age usually take the same dose, up to three times a day, depending on age. Children under 2 years of age are twice a day for 60 mg of Miconazole.

Dose for intravenous administration depends on the susceptibility to and severity of miconazole natratu infection and from 200 mg to 3, 6 grams per day.

Miconazole ointment used for fungal skin diseases. The preparation is applied in the morning and in the evening a thin layer, and thoroughly rubbed. The duration of treatment typically ranges from two to six weeks depending on the symptoms.

In the treatment of onychomycosis miconazole ointment applied thinly to the nail bed twice a day and then impose an occlusive dressing. Treatment of miconazole instructions effectively continue until the final formation of a new nail.

Miconazole gel for oral administration is indicated for the treatment and prophylaxis of fungal infections of the gastrointestinal tract,  Candles miconazole
 oral cavity. Typically prescribed dosage spoon on the floor four times a day. The gel is recommended to delay as long as possible in the mouth and then swallow. Generally, treatment is continued for at least a week after the disappearance of symptoms.

Candles used for miconazole vaginal mycosis once a day at bedtime. After the disappearance of the symptoms of the treatment should be carried out more for at least two weeks.

Side effects

According to the instructions of miconazole with systemic use can cause different side effects - nausea, itching, phlebitis, vomiting, skin rash, anaphylactic reactions.

Prolonged treatment may develop diarrhea, and in some cases - hepatitis.

Miconazole ointment when applied externally can cause skin irritation and contact dermatitis.

Storage conditions

The drug is available without prescription. According to the instructions of miconazole in any dosage forms should be stored in a dark place.





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