Metronidazole

 Metronidazole Tablets

Metronidazole - an effective antibacterial and antiprotozoal drug is a synthetic broad-spectrum.

Pharmacological action

The active ingredient Metronidazole has antibacterial and antiprotozoal activity against:

  • Peptococcus niger .;
  • Bacteroides spp., Including Bacteroides distasonis, Bacteroides thetaiotaomicron, Bacteroides fragilis, Fusobacterium spp., Bacteroides ovatus, Bacteroides vulgatus;
  • Entamoeba histolytica;
  • Clostridium spp .;
  • Trichomonas vaginalis;
  • Eubacterium spp .;
  • Peptostreptococcus spp;

Metronidazole in combination with amoxicillin also effective against Helicobacter pylori.

According to the instructions Metronidazole causes sensitization to alcohol, increases the sensitivity of tumors to radiation and stimulates the reparative processes.

Product form

Metronidazole is available in different dosage forms:

  • Valium white tablets Metronidazole, 250 mg of the active ingredient, of 20 pieces in banks of 10 pieces in blister;
  • Metronidazole candles, containing 0, 1 g in each suppository. 10 candles in the package;
  • Yellowish transparent solution for infusions in polyethylene bottles containing 500 mg of active ingredient;
  • Colorless 1% vaginal gel. 100 g Metronidazole Gel contains 1 g of active substance. The aluminum tubes to 30 grams complete with applicator.

Indications Metronidazole

According to the instructions Metronidazole is used to treat:

  • Infections caused by Bacteroides species - the abdominal cavity, including peritonitis, liver abscess, pelvic organs, including endomyometritis, endometritis, an infection vaginal vault after surgery, an abscess of the fallopian tubes and ovaries, as well as soft tissue infections, and skin;
  • Infections caused by Bacteroides species and Clostridium - sepsis;
  • Gastritis or duodenal ulcers that are caused by Helicobacter pylori;
  • Protozoal infections - intestinal amebiasis, balantidiasis, extra-intestinal amebiasis, trichomoniasis, including amebic liver abscess, Trichomonas vaginitis giardiazisa, cutaneous leishmaniasis, Trichomonas urethritis;
  • Infection caused by Bacteroides spp., Including B. distasonis, B. fragilis, B. vulgalus B. ovatus, B. thetaiotaomicron - an infection of the joints, bones, central nervous system, including brain abscess and meningitis as well as pneumonia, bacterial endocarditis, empyema and lung abscess;
  • Alcoholism;
  • Pseudomembranous colitis, which is associated with the use of antibiotics.

Metronidazole is also used according to instructions:

  • For the prevention of postoperative complications in the region and okolorektalnoy colon, gynecological surgery and appendectomy;
  • For radiation therapy in oncology, as a radiosensitizing agent.

Candles Metronidazole is used for urogenital trichomoniasis and bacterial vaginitis, which causes sensitive microorganisms.

Contraindications

According to the instructions to use Metronidazole is contraindicated in case of:

  • Organic lesions of the central nervous system, including epilepsy;
  • Leukopenia, including history;
  • Hepatic failure if large doses are appointed.

Taking metronidazole is contraindicated in case of hypersensitivity to the drug, and also in the first trimester of pregnancy and lactation.

Metronidazole prescribed with caution in the second and third trimesters of pregnancy and in patients with renal or hepatic insufficiency.

Instructions for use metronidazole

According to the description Metronidazole pills taken after meals. The dosage and duration of treatment depends on the disease:

  • Trichomoniasis - twice a day for 2 Metronidazole tablets for 10 days. Also during the treatment to be applied vaginally candles Metronidazole, 2 suppository twice a day - morning and evening. This therapy candles Metronidazole is recommended to start at the beginning of the menstrual cycle, and during this period to avoid douching. If necessary, treatment of trichomoniasis may be repeated a month later. Dosage for children depending on the age - 2-5 years prescribed 250 mg per day, 5-10 years - to 375 mg, older - 500 mg per day;
  • Giardiasis Metronidazole used within 5-7 days twice a day, 2 tablets;
  • In identifying cysts in asymptomatic amebiasis - for 5-7 days Metronidazole 2 tablets up to 3 times a day;
  • In chronic amebiasis daily dose metronidazole is 1, 5 g, which can be divided into three stages. Take for 5-10 days;
  • In acute amoebic dysentery - until the termination of symptoms take 2, 25 g, divided into 3 doses;
  • When a liver abscess in combination with antibiotics of the tetracycline group and other therapies - for 3-5 days maximum of 2, 5 grams of metronidazole;
  • When balantidiasis - for 5-6 days, 750 mg 3 times a day;
  • In ulcerative stomatitis - 2 tablets metronidazole twice daily until 5 days;
  • For the treatment of chronic alcoholism take 2 tablets per day metronidazole up to six months.

 Metronidazole candles
 The daily dose in severe renal impairment should be reduced by half.

If it is impossible to use Metronidazole inside, as well as severe infections, intravenous drug use.

Generally, the dose is 500 mg, not more than 4 grams per day. In the event of improvements make the transition to oral medication.

Description of side effects of metronidazole

In the opinion of Metronidazole may cause the following side effects:

  • Diarrhea, anorexia, constipation, nausea, glossitis, dry mouth, vomiting, a metallic taste in the mouth, pancreatitis;
  • Cystitis, dysuria, urinary incontinence, polyuria, candidiasis, urine staining in red-brown color;
  • Dizziness and incoordination, confusion, irritability, depression, hallucinations, irritability;
  • Rash, fever, skin rash, skin flushing, stuffy nose, arthralgia;
  • Neutropenia and leucopenia.

According to the description Metronidazole often cause insomnia, headaches and weakness.

Intestinal cramps, stomatitis, cramps, fever, ataxia and metronidazole, in the opinion, is much rarer.

Care should be taken while applying Metronidazole with other drugs because of the possibility of adverse side effects. During therapy with metronidazole Review alcohol is not recommended because of the possibility of neurological symptoms and the appearance of abdominal pain of spastic character, vomiting and nausea.

Storage conditions

The preparation is available only by prescription. Shelf life of Metronidazole tablets and suppositories - 2 years.





Яндекс.Метрика