Methylprednisolone

 Methylprednisolone
 Methylprednisolone - hormonal drug.

Pharmacological action

Methylprednisolone belongs to glucocorticosteroids has antishock, immunosuppressive, anti-inflammatory, desensitizing, protivotoksicheskoe action.

Preparations tend to increase the excitability of the nervous system, reduces the number of lymphocytes, increase the number of red blood cells.

Participating in protein metabolism, Methylprednisolone reduces protein stimulates liver, kidney albumin enhances muscle protein processing.

In the process of lipid metabolism Methylprednisolone increases the production of higher fatty acids, redistributes fat (mostly on the abdomen, shoulders, face).

Taking part in the metabolism of carbohydrates, Methylprednisolone promotes absorption of carbohydrates from the digestive tract, increases the amount coming from the liver into the blood glucose.

The electrolytic-water exchange Methylprednisolone plays the role of agent to retain water and sodium, which stimulates the excretion of potassium, which reduces absorption of calcium from the digestive tract, increases the excretion of calcium by the kidneys.

Methylprednisolone atseponat - glucocorticosteroid outdoor use, has anti-allergic, anti-inflammatory, antiexudativ action.

When applying application means for vessels shows vasoconstrictor effect (inhibits mucus tissue of the vessels).

Product form

Methylprednisolone release tablets, solution. Methylprednisolone atseponat - as an ointment.

Indications Methylprednisolone

Methylprednisolone take in kollagenozah (diseases that exhibit diffuse damage to the connective tissue and blood vessels), rheumatism, infectious nonspecific polyarthritis, asthma, myeloid leukemia, acute lymphoblastic leukemia, infectious mononucleosis, neurodermatitis, eczema, other skin diseases, diseases of allergic origin.

Methylprednisolone is also indicated in the instructions that it can be administered in Addison's disease, acute adrenal insufficiency, hemolytic anemia, acute pancreatitis, glomerulonephritis, patients in a state of collapse and shock, those who underwent transplantation of tissues, organs (to prevent rejection).

Methylprednisolone atseponat effective in atopic dermatitis, atopic dermatitis, eczema degenerative, contact, disgidroticheskoy.

You can apply an ointment for the treatment of eczema in children.

Contraindications

Methylprednisolone should not be prescribed according to the instructions in severe hypertension, diabetes mellitus, Cushing's disease, acute endocarditis, circulatory failure, the third stage, osteoporosis, gastrointestinal ulcers, syphilis, active tuberculosis, after the recent operations. Do not take Methylprednisolone pregnant women, elderly patients, children up to 12l.

Methylprednisolone atseponat contraindicated in specific skin lesions: chicken pox, tuberculosis, syphilis, skin reactions to vaccination, viral diseases.

Instructions for use Methylprednisolone

Metileprednizolon intravenously, intramuscularly inject with adrenal insufficiency children in such quantities: 0, 14mg / kg / day of h / r two days. In other indications the children prick 0, 139-0, 835mg / kg every 12-24ch. Adults shown stabbing 4-60mg / day for 1-4ned.

In a state of cardiogenic, burns, anaphylactic, traumatic shock or rejection of transplanted organs, tissues, children, adults intravenous 4-20mg / kg Methylprednisolone. Over a short period can increase the dosage to 30mg / kg. The duration of intravenous infusion - at least 10 minutes at intervals of 30 minutes - per day.

To eliminate vomiting, nausea provoked cytostatics take 250mg Metileprednizolona for 20min (or c / o 6h after) before taking the drugs. Children are no less than 25 mg / day.

When bronchial asthma Methylprednisolone are inside - start treatment with a daily dose of 12-40mg. Supportive care - 4-12mg / day.

D  Methylprednisolone solution
 To the treatment of chronic polyarthritis take 6-20mg a day (at the beginning of therapy). In the treatment of rheumatism starting dose Methylprednisolone on instructions - 0, 8-1, 5 mg / kg (gradually reduce it).

The ointment is applied to one Methylprednisolone atseponat p / day to the affected area with a thin layer of eczema, gently rubbing. You may use the ointment with occlusive dressing. Treatment of adult patients 12ned lasts no more and no more 4ned - for children. Throughout the year, you can spend a few treatments.

side effects

Methylprednisolone causes sodium retention, water, leads to loss of potassium can cause high blood pressure, muscle weakness, damage to the walls of the stomach, menstrual disorders, adrenal function.

Because of Methylprednisolone may develop osteoporosis, mental disorders, drop resistance to infection.

Ointment during long-term therapy can cause erythema, rash, burning, itching, skin atrophy, acne, hypertrichosis, folliculitis, dermatitis, allergic reactions.





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