Metamizole

Metamizole (in Russia known as Analgin) is a drug from the group of pyrazolones and has analgesic effect. The drug effectively relieves pain of various etiologies, blocks the passage of pain impulses along nerve bundles, raises the pain threshold.  Formula Metamizole

Structure and Composition

The preparation consists of a sodium salt of methanesulfonic acid. Metamizole is a pyrazolone derivative.

Produced in capsules and tablets, as well as a solution for intravenous or intramuscular administration. For children, rectal suppositories are available.

Pharmacological properties Metamizole

Metamizole has a pronounced anti-inflammatory action, antipyretic and anti-inflammatory properties. The drug is active on smooth muscles and muscles urinary tract, spasms and eliminating pain.

The therapeutic effect of the active substances develops within 20-30 minutes of ingestion. Metamizole sodium excreted from the body within 5 hours.

In the treatment of children under 5 years old should take the drug only under the supervision of a doctor.

Patients with asthma have the risk of allergic reactions to the drug.

Indications Metamizole

Metamizole appointed in infectious and inflammatory diseases, allergic reactions occurred after insect bites, as well as the pain syndrome, including neurology, gastrointestinal and biliary colic, injuries, burns, sciatica, myositis, herpes.

Analgesic relieves pain of varying severity in the postoperative period, as well as eliminates the tooth and headache.

Instructions for use Metamizole

Metamizole is prescribed for adults 2-3 times daily, 500 mg, and children up to 5 years 100 mg and up to 10 years - 200 mg. The daily dose for adults should not exceed 3 g, and for children - 1 year

When assigning metamizole sodium injectable solution must match the patient's body temperature. Improperly selected dose may lead to a sharp decrease in pressure and coma.

The dose of the drug in the form of rectal for adults should not exceed 1000 mg, and for children - no more than 400 mg. Children with the introduction of the drug in the form of candles should be in a prone position and complete rest.

Chronic administration of the drug should carefully monitor the condition of the peripheral blood. Do not take Metamizole to relieve acute pain without finding out their causes.  The main active ingredient baralgin - Metamizole

Contraindications

Contraindications to receive Metamizole are hypersensitivity and idiosyncrasy of components of the drug, the presence of infectious neutropenia, liver and kidney failure and anemia is a hereditary character, which is associated with deficiency of glucose.

It should appoint Metamizole in the "aspirin" asthma, reducing the amount of white blood cells in the blood and allergy to acetylsalicylic acid.

Precautions drug is given during pregnancy and lactation, aged 4 months, and also when receiving drugs with ethanol content.

Side effects Metamizole

Side effects when taking Metamizole can wear pronounced and accompanied by various complications.

With the genitourinary system, the following side effects: kidney failure, anuria, interstitial nephritis, proteinuria.

From the circulatory system: leukopenia, thrombocytosis, agranulocytosis.

The drug can cause allergic reactions: allergic conjunctivitis, urticaria, rash, angioedema, toxic necrolysis, bronchospasm, anaphylactic shock.

Should not be taken Metamizol sodium simultaneously with other analgesics, codeine and myelotoxic drug that can cause toxic or diseases of the circulatory system.





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