Mannitol - a drug to increase urine.
Mannitol called osmotic diuretic, which by increasing the pressure in the plasma and an increase in water retention is filtration, and an increase in urine volume. A drug increasing the pressure of the plasma results in that fluid passes from brain tissue or blood vessels in an eyeball. An additional effect of mannitol - increase in blood volume, which must take into account the application of funds.
The higher dosage of mannitol, the better its diuretic effect is manifested.
In violation of the kidneys' ability to filter incoming liquid, azotemia, develop in patients with ascites or hepatic cirrhosis, the use of mannitol ineffective.
Mannitol is produced as a solution.
The drug is prescribed with increased intracranial / intraocular pressure, status epilepticus, acute renal failure, including in step oliguria, brain edema, glaucoma, acute liver failure, poisoning with barbiturates, bromides, salicylates, lithium, for diuresis in other types of poisoning.
The instructions mannitol indicate that it can be used for forced diuresis case of poisoning, for operations with extracorporeal circulation, for the prophylaxis or hemoglobinemia hemolysis in prostate surgery or cardiopulmonary system (e.g., conducting surgery), at an acute oliguria - for determination index glomerular filtration rate.
Before perfusion during the operation, which is applied to an artificial blood circulation, also using mannitol.
Instructions mannitol: how to use
The drug is administered dropwise or stream (slow) intravenously - 10-20% solution in dosages 0, 5-1, 5 g / kg, and the daily dosage does not exceed 140-180g.
If the drug powder, its solution directly before a shot - in destroze 5%. Prior to injection, the solution of mannitol is recommended to warm up to 37 degrees.
Before perfusion 20-40g administered drug.
Mannitol can cause dehydration, whose symptoms: dry mouth, indigestion, pressure reduction, dry skin, seizures, myasthenia gravis, hallucination, and the imbalance of water and electrolytes, thrombophlebitis, skin rash.
There are reviews of mannitol, causing chest pain, tachycardia.
If the patient complains of vomiting, blurred vision, headache, dizziness, necessary to exclude subarachnoid / subdural brain hemorrhage.
Diuretics should not be used in patients with renal chronic disease, hypersensitivity, worsening kidney filtration function, stroke, severe dehydration, subarachnoid hemorrhage, hypochloremia, hypokalemia, hyponatremia.
Pregnant women, lactating women are allowed to take Mannitol, but with great caution, under medical supervision.
Ototoxic and nephrotoxic effects can occur in combination with mannitol, neomycin. Toxicity under the influence of the drug exhibit cardiac glycosides - increase the risk of hypokalemia.
The diuretic effect of the drug is enhanced while the appointment with other diuretics.