Magnesium sulfate

Pharmacological action

 Magnesium sulfate powder

Magnesium sulfate is a drug, a therapeutic effect depends on the method of application.

Thus, the ingestion of magnesium sulfate has a laxative and choleretic effect.

The laxative effect of the drug due to its poor absorption, which leads to the creation of high osmotic pressure the intestine, which leads to the accumulation of water, and dilution of the contents of the intestine as a result, increased peristalsis.

Choleretic effect of magnesium sulfate due to its reflex action on the mucous membrane of the duodenum.

This tool is an antidote for poisoning with salts of heavy metals.

Magnesium sulfate starts to operate at 0, 5-3 hours after oral administration, the therapeutic effect lasts for 4-6 hours.

Intravenous and intramuscular use of magnesium sulfate has a diuretic, vasodilator, antiarrhythmic, anticonvulsant, antispasmodic and sedative effect. Parenteral administration of large doses of the drug can cause tocolytic (prevents premature birth), hypnotics, kurarepodobnymi (inhibits neuromuscular transmission) and the narcotic effect of the drug.

The use of magnesium sulfate allows to reduce the excitability of the respiratory center, decrease blood pressure, due to the soothing properties of the drug, to increase urination.

After intravenous administration, the drug takes effect almost immediately, while maintaining its therapeutic effect over an hour. After intramuscular administration of magnesium sulfate takes effect after 60 minutes and continues for the next 3-4 hours.

Indications of magnesium sulfate

Magnesium sulfate powder, which is designed for the preparation of a suspension or solution for oral administration, is prescribed for constipation, cholecystitis (acute inflammation of the gall bladder), cholangitis (inflammation of the bile duct), gallbladder diskenzii (violation abridged), duodenal sounding, peeled bowel before diagnostic procedures.

Magnesium sulfate in ampoules containing solution for intramuscular or intravenous administration, is used for:

  • hypomagnesemia;
  • cramps in gestosis (body systems disorder during pregnancy);
  • threat of premature birth;
  • hypertension;
  • epileptic syndromes;
  • encephalopathy (brain disease non-inflammatory nature);
  • eclampsia (high blood pressure is critical for pregnant women or pregnant women);
  • urinary retention.

Magnesium sulfate in any dosage form effective for poisoning by heavy metal salts such as arsenic, tetraethyl lead and mercury.

Contraindications

Oral magnesium sulfate applied instruction is not recommended for rectal bleeding, appendicitis, intestinal obstruction, dehydration, gipermagniemii.

Magnesium sulfate in vials for parenteral use is contraindicated in the oppression of the respiratory center, hypotension, bradycardia, AV block. Do not use the drug for 2 hours before giving birth.

Magnesium sulfate in any dosage form is not assigned in chronic renal failure and hypersensitivity to the drug.

Instructions for use of magnesium sulfate

Before ingestion, magnesium sulfate powder was dissolved in 100 ml of water is slightly heated. For laxative effect as a single dose for adults using the contents of one packet (20-30 g), and for children - the amount in grams of powder must correspond to the child's age in years.

Magnesium sulphate 20-25% solution is taken orally as needed obtain choleretic effect - 3 times a day for 15 ml. Duodenal intubation involves gavage 10% (100 ml) and 25% (50 ml) warm solution. To cleanse the stomach from salts of heavy metals is carried out or washing a 1% solution or the patient ingests 20-25 g of magnesium sulfate powder dissolved in 200 ml of water. The daily dose for adults should not exceed 40 grams of the drug.

 Magnesium sulfate ampoules
 Magnesium sulfate ampoules for parenteral administration, which should be carried out slowly - during the first three minutes should not be administered more than 3 ml. Typically, the drug is used 1-2 times a day for 5-20 ml using a solution of 20-25%. Duration of treatment - 2-3 weeks.

To cleanse the body of heavy metal salts of magnesium sulfate given intravenously manual recommends a 5-10% solution of 5-10 ml.

Relief of seizures in children involves intramuscular administration of the preparation, the rate of 20-40 mg per kg.

side effects

Magnesium sulfate can cause unwanted reactions of the body such as:

  • exacerbation of diseases of the digestive tract, diarrhea, vomiting, nausea, flatulence, thirst, in the case of kidney failure - gipermagniemii symptoms (dizziness);
  • electrolyte imbalance, which manifests itself in the form of seizures, arrhythmias, confusion, fatigue, fatigue.

Gipermangiemiya at an early stage can be expressed by a decrease in blood pressure, headache, shortness of breath, weakness, vomiting, nausea, blurring of speech, bradycardia, sudden "tides" of blood to the face.

Excessive concentration of magnesium in the blood serum has the following features: depression of the respiratory center, loss of deep tendon reflexes, impaired cardiac conduction, heart failure, anxiety, increased sweating, increased production of urine, deep sedation (depression of consciousness), atonic uterus (sharp decline and loss of tone contractility of the muscles).

Additional Information

Store magnesium sulfate guide recommends at room temperature, this condition will allow the drug remain valid for 5 years.





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