Losap

Losap - pharmacological agents from the group of angiotensin receptor antagonists II, used to treat hypertension.

Structure and Composition

 Losap Plus
 Losap available in tablets (dosage of 12, 5 and 50 mg). The active ingredient - losartan. Tablets contain instructions for Lozap following auxiliaries: microcrystalline cellulose, mannitol, colloidal silicon dioxide, crospovidone, talc, magnesium stearate, hypromellose, macrogol, titanium dioxide.

Lozap Tablets - oval, biconvex, film-coated. The drug is produced in blister packs of 10 tablets. The carton can be 3, 6 or 9 of plastic blisters with instruction.

Pharmacological action Lozap

According to the instructions, Losap relates to specific angiotensin II receptor antagonist and has a hypotensive effect. The drug reduces the total peripheral vascular resistance, lowers blood pressure, reduces stress on the heart muscle, reduces blood levels of adrenaline and aldosterone, has a diuretic effect. Losap increases exercise tolerance in patients with chronic heart failure and prevents myocardial hypertrophy.

After a single dose Lozap maximum hypotensive effect develops within 6 hours, and gradually decreased for 24 hours. With continued taking the drug the maximum antihypertensive effect occurs after 3-6 weeks from the beginning of the reception Lozap.

Application Lozap patients with hypertension and proteinuria greater than 2 g / day significantly reduced the loss of protein in the urine, urinary albumin and immunoglobulins. At doses up to 150 mg per day Losap no effect on blood glucose (fasting) and lipid profile parameters.

Once inside Losap well absorbed, metabolized in the liver. Bioavailability of 33%. Withdrawal of the drug and its metabolites mainly through the intestines and kidneys.

Losap practically does not penetrate the blood-brain barrier.

Indications

Losap used to treat hypertension. Also, the drug is shown in the complex treatment of patients with chronic heart failure, diabetic nephropathy (a hypercreatininemia and proteinuria). According to the instructions Losap can be used to reduce the risk of cardio - vascular complications in patients with hypertension and left ventricular hypertrophy.

Contraindications Lozap

Lozap drug is contraindicated in the following cases:

  • hypersensitivity to losartan and other ingredients;
  • age 18 years (clinical studies on the safety of this group have not been made);
  • pregnancy and lactation.

Precautions Losap used for violations of water-electrolyte metabolism, with bilateral renal artery stenosis, or renal artery stenosis of a solitary kidney, as well as signs of kidney or liver failure.

Use during pregnancy and lactation

Clinical studies on the use of Lozap during pregnancy have not been conducted. It should be noted that the known fact that drugs which act on the angiotensin system aldosternovuyu, teratogenic (causing birth defects and even death of the fetus). If the pregnancy is in the background of Lozap, it should be lifted immediately. During lactation, the drug is also not recommended for use.

Dosing and Administration Lozap

This drug is taken orally one time a day, depending on the time of reception of eating the food there.

In the treatment of hypertension Lozap average dose is 50 mg. If necessary, the dose may be increased to 100 mg.

In chronic heart failure it is recommended to take Losap 12, 5 mg per day. The dose may be increased (at weekly intervals) with good tolerability of the drug.

If the patient with heart failure receiving large doses of diuretics (diuretics), the dose Lozap reduced to 25 mg per day.

Patients with impaired renal function, liver and elderly patients a lower recommended starting dose of the drug (25 mg per day).

side effect

According to reviews Losap rarely causes side effects. If side effects occur, this condition is usually transient and do not require discontinuation of therapy. The most frequent side effects Lozap the treatment of hypertension is dizziness (4, 1%). Orthostatic effects Lozap Review noted in less than 1% of patients.

The rest of the side effects Lozap not differ from side effects with placebo ("dummy"), so their relationship with the reception of the drug is uncertain. These adverse symptoms include: asthenia, fatigue, pain in the chest, swelling of the extremities, palpitations, diarrhea, abdominal pain, nausea, pain in the back and / or legs, leg cramps, headache, insomnia, cough, nasal congestion .

Overdose Losap

With an overdose of the drug may be a marked decrease in blood pressure, tachycardia (sometimes bradycardia). Treatment involves administering symptomatic treatment, the use of forced diuresis. Hemodialysis in overdose Losap not effective.

Interaction with other drugs

According to the instructions, Losap can be combined with other antihypertensive agents, it enhances the action of mutually simpatolitikov and beta adrenolokatorov.

In a joint application Lozap and diuretics marked potentiation of both drugs.

When concomitantly with digoxin, hydrochlorothiazide, warfarin, cimetidine, phenobarbital, ketoconazole and erythromycin pharmacologic interaction was found. In the opinion of Losap well with these drugs without causing any symptoms.  Losap pills

Application Lozap with potassium-sparing diuretics (spironolactone, amiloride, triamterene) increases the risk of hyperkalemia.

Special instructions for use Lozap

Start the application of this preparation should be at a lower dose, as necessary to carry out the correction of water and electrolyte balance before prescribing Lozap.

In patients with liver cirrhosis the concentration of the drug in the blood increases, therefore it is necessary to use it at lower doses.

It is recommended to monitor the concentration of potassium in the blood in the elderly and impaired renal function during therapy Losap.

Effects on ability to drive a car or other mechanisms

According to the instructions Losap no effect on the ability to drive and the ability to focus when working with moving machinery.

Analogs Lozap

Lozap analogues are drugs from the same group receptor antagonists angiotensin II, these include: Lorista, Vazotenz, Losartan, Prezartan, Cozaar, Bloktran, Renikard, Brozaar, Lozarel, Lothor.

Before replacing analogue Lozap should consult a doctor. These preparations are not intended for self-use.





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