Lipin

 Lipin

Lipin - natural fosfatidinholin used as part of combination therapy in the treatment of acute respiratory failure and other diseases.

The drug is widely used in pediatric patients, including newborns.

Pharmacological action

Due to its pharmacological properties Liping affects the digestive system, the processes of tissue respiration and overall metabolism. As a natural fosfatidinholin, Liping also has a strong immunomodulatory effect antihypoxic and updating the functional activity of endothelial cells and improving microcirculation and blood composition.

When inhaled route of administration Liping beneficial effect on the alveolar and pulmonary ventilation by increasing the power of oxygen to tissues.

Lipin is not toxic, it does not accumulate in the tissues and cells of the body, and does not violate the state organs and their systems.

Liping reaches maximum concentration rapidly within 5 minutes after administration and maintained for about 5 hours.

Product form

Liping is available in powder form for the preparation of emulsions, in bottles of 100, 250 and 500 mg single inhaler NEBULISER.

Indications Lipin

Liping instructions for use as part of combination therapy in the treatment of various diseases:

  • In acute and chronic respiratory failure, regardless of origin pathology. Liping appointed as newborns who have respiratory disorders after undergoing hypoxia or in the case of asphyxia at birth;
  • In acute myocardial infarction and unstable angina type;
  • In chronic and acute active hepatitis, ulcerative colitis, nekalkuleznogo cholecystitis, cirrhosis of the liver;
  • In polycystic kidney disease, chronic and acute pyelonephritis and glomerulonephritis, renal failure;
  • When fetal hypoxia late gestosis.

Contraindications

Liping of instructions has no contraindications but are hypersensitive to the components of the drug.

Instructions for use Lipin

Liping used intravenously, by inhalation, orally and rectally using liposomal emulsion prepared immediately before use.

To prepare the emulsions of the active vial LIPIN warmed to room temperature for at least an hour, after which it was added physiological saline for injection (100 mg in 10 ml of lyophilizate saline). Then, the resulting solution was stirred until a homogeneous emulsion for 2-3 minutes. If the emulsion is to be used only rectally or orally, it can be prepared on the basis of distilled or boiled water.

In pulmonology used emulsion prepared in the ratio of 50 mg powder to 1 ml of saline for injection. The resulting emulsion was applied on one inhalation rate of 10-15 mg per 1 kg of body weight. The course of treatment - from five to ten days to two inhalations once a day. In the application can not be used Lipin paroaerozolnye inhalers.

 Liping administered intravenously in severe cases

Instructions for Intravenous Liping used in severe cases, up to 3 times a day, based on the calculation of 10-15 mg per 1 kg of body weight. The drug is injected slowly, the rate depends on the severity of disease and can range from 3 to 10 days.

The optimal duration of inhalations for newborns with signs of respiratory distress is 4 minutes, course of treatment - from 5 to 12 days.

Oral Liping used in the treatment of acute hepatitis B in the active form or a chronic course of the disease, as well as in liver cirrhosis and chronic cholecystitis nekalkuleznogo, twice a day for 1 year standard treatment is carried out for 21 days. In severe cases, Liping on the instructions can be used intravenously, for which the drug is diluted in 5% glucose solution. Treatment is carried out over 10 days to 1 g twice daily.

In nephrology Liping used only as part of combination therapy with antibiotics. Lipina dose calculated from 10-20 mg per 1 kg of body weight. Usually treatment is 4 days. In the treatment of chronic pyelonephritis, glomerulonephritis and diabetic nephropathy in the stage of chronic renal failure, such as a course of treatment is not less than two weeks.

side effects

At therapeutic doses, Liping usually well tolerated.

In some cases, you may experience headaches, fever, palpitations, weakness or pain along the vein. When using Lipin if you are hypersensitive may be some allergic reactions - nausea, hives, or itching. In the case of manifestation of these effects is the use of the drug should be discontinued and carry antihistamine therapy in combination with ascorbic acid and calcium chloride.

If necessary Liping can be used in the treatment of pregnant and lactating women.

Liping of instructions can be used in combination therapy with antibiotics, steroids, cytostatics, choleretic, and Vitamins. When using Liping should not be mixed in the same syringe or an inhaler with other drugs.

Overdose cases are not fixed Liping.

When applying Lipina be appreciated that the formulation comprises lactose, so the hereditary component of intolerance, as well as lactose deficiency syndrome or gluco-galactose malabsorption, it should not be used.

storage conditions

Liping released by doctor's prescription. When storing the drug should observe the temperature regime is not higher than -10 degrees Celsius. Emulsion is stored no longer than 6 hours in a refrigerator at 6 ° C. The shelf life of the drug - 1 year.





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