Lincomycin

 Lincomycin Capsules

Lincomycin - antibiotic used for the treatment of various diseases caused by the majority of Gram-positive bacteria.

Pharmacological action

Lincomycin being antibiotic in therapeutic doses active against:

  • Streptococcus spp., Including Streptococcus pneumoniae;
  • Bacteroides spp .;
  • Mycoplasma spp .;
  • Staphylococcus spp., Including strains that produce penicillinase;
  • Corynebacterium diphtheriae;
  • Clostridium spp.

According to the instructions, lincomycin not affect the majority of Gram-negative bacteria, viruses, Enterococcus faecalis, fungi and protozoa.

Lincomycin slow to develop resistance rapidly distributed in tissues and body fluids, including bone and crosses the placental barrier.

When using Linkomitsina should consider that between clindamycin and drug cross-resistance exists.

Product form

Lincomycin produced in the form:

  • White with a yellow lid lincomycin capsules containing 250 mg of active substance - lincomycin hydrochloride as a white powder, 10, 20, 360 pieces per pack;
  • 2% ointment for topical application, of 10 or 15 grams in the box;
  • Solution for intramuscular and intravenous Linkomitsina hydrochloride containing 300 or 600 mg of active substance in the vial, 5, 10, 100 vials in the package.

Indications Linkomitsina

Lincomycin for instructions used to treat severe occurring infectious and inflammatory diseases, including:

  • Bacterial endocarditis;
  • Pneumonia;
  • Sepsis;
  • Lung abscess;
  • Wound infections;
  • Osteomyelitis;
  • Pleural empyema.

Ointment lincomycin used topically for the treatment of inflammatory skin diseases.

In dentistry, lincomycin is used to treat a variety of infections of the maxillofacial system. Its main advantage compared with other antibiotics is the ability to be deposited in the bones and teeth.

Quite often lincomycin used in dentistry in conjunction with lidocaine to remove purulent processes in gingivitis, periodontitis or periodontitis.

Lincomycin is also used to avoid attachment of secondary infection on the wound surface in the wells after tooth extraction. There is no single opinion about the appropriateness of the drug in these cases.

Also, direct guidance in the instructions for use in dentistry Linkomitsina not, therefore, the question of its use must be addressed with your doctor.

Contraindications Linkomitsina

According to the description, Lincomycin is contraindicated in sensitivity to the active ingredients of the drug (clindamycin or lincomycin), as well as for violations expressed fuektsy kidneys and liver.

Application Linkomitsina contraindicated during lactation and pregnancy because of the penetration of the drug through the placenta.

Instructions for use Linkomitsina

When receiving Linkomitsina capsules used 3-4 times daily 500 mg. Typically the duration of treatment ranged from one to two weeks, osteomyelitis - up to three weeks or more. Capsules Linkomitsina take a few hours before a meal with a small amount of liquid.

Intravenous lincomycin for instructions used up to 2 times a day 600 mg.

Intravenous drip Linkomitsina hydrochloride is used at 600 mg once a day.

Children appoint lincomycin capsule daily dose calculated as 30-60 mg per 1 kg of body weight.

 Lincomycin solution of 10%
 If necessary, the hydrochloride Linkomitsina administered intravenously every 8-12 hours at the rate of 10-20 mg per 1 kg of body weight.

When applied topically as an ointment Lincomycin applied thinly on the affected skin several times a day. The ointment is applied with caution in ringworm and fungal skin diseases.

In an application Linkomitsina with cephalosporins, penicillin, erythromycin and chloramphenicol may antagonize the antimicrobial action, and while the use of aminoglycosides - a synergistic effect.

Caution should be used simultaneously with lincomycin means peripherally acting muscle relaxants and inhalational anesthesia because of the potential gain of neuromuscular blockade, leading sometimes to the development of sleep apnea.

Antidiarrheal drugs lead to a reduction of bactericidal action Linkomitsina.

When using Linkomitsina should be aware that pharmaceuticals are not compatible with:

  • Novobiocin;
  • Kanamycin;
  • Barbiturates;
  • Calcium gluconate;
  • Heparin;
  • Ampicillin;
  • Theophylline;
  • Magnesium sulfate.

Description of side effects Linkomitsina

According to the instructions, and reviews, Lincomycin may cause the following side effects:

  • GLOSS
  • Epigastric pain;
  • Reversible leukopenia;
  • Stomatitis;
  • Exfoliative dermatitis;
  • Diarrhea;
  • Anaphylaxis;
  • Increased liver transaminases and bilirubin in the blood plasma;
  • Nausea;
  • Candidiasis;
  • Neutropenia;
  • Vomiting;
  • Thrombocytopenia;
  • Hives;
  • Angioedema.

With prolonged use of high doses of lincomycin may develop pseudomembranous colitis.

For intravenous use, may develop phlebitis, with rapid intravenous administration can be observed a general weakness, dizziness, relaxation of skeletal muscles and lowering blood pressure.

Storage conditions

Lincomycin released on the doctor's prescription. According to the disclosure, the shelf life of the capsules Linkomitsina - 4 years, solution for injection and ointments - 3 years.





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