Lidevin

 Lidevin
 Lidevin - agent for the treatment of pathological craving for alcohol.

Pharmacological action

Lidevin - combined tool, based on a combination of B vitamins and disulfiram.

Disulfiram composed Lidevin atsetaldegiddegidrogenaza blocks an enzyme located in the liver and causes an increase in the concentration of acetaldehyde (a metabolite of ethanol), resulting in an unpleasant feeling of malaise, vomiting, flares, nausea, tachycardia, pressure reduction. All these reactions contribute to the development of the reflex reaction of disgust to alcohol - and their taste and smell after treatment Lidevin.

Vitamins included in the normalization process Lidevin respiratory tissues.

Judging by the reviews of Lidevin, the maximum therapeutic effect after it reaches 12 hours after ingestion and lasts more 10-14dn. after the end of the therapeutic course.

Product form

Lidevin release tablets.

Indications Lidevin

Lidevin according to the instructions indicated for the treatment of chronic alcoholism and prevent its recurrence.

Contraindications

Lidevin can not be used when: thyrotoxicosis, expressed cardiosclerosis, atherosclerosis of brain vessels, in pre-and post-infarction states, in case of hypersensitivity, arterial hypertension 2-3y extent, other urological diseases of the cardiovascular system, with severe coronary insufficiency, pulmonary tuberculosis, accompanied by hemoptysis, bronchial asthma , severe pulmonary emphysema.

Also, do not prescribe Ledivin erosive lesions in the gastrointestinal mucosa, gastrointestinal ulcers, kidney failure, liver, diabetes mellitus, epilepsy, and other neuropsychiatric pathologies, infections of the nervous system, neuritis of the visual, auditory nerves, polyneuritis, malignant tumors, glaucoma, during lactation , pregnancy.

The instructions Lidevin stated that caution should be taken medication: elderly patients after 60l, patients with endateriitom, circulatory disorders of the brain, psychosis provoked by disulfiram (in the past), gastrointestinal ulcers in remission.

If Lidevin administered with anticoagulants is necessary to control the amount of prothrombin and adjust the dose of anticoagulants, as there is a risk of bleeding.

During therapy, it should be noted that the action Lidevin increase isoniazid, metronidazole, tricyclic antidepressants (eg, amitriptyline). The simultaneous use of Lidevinom isoniazid can cause behavioral disorders, motor coordination, phenytoin increases the risk of side effects, and tinidazole, ordinazol, metronidazole, seknidazol - the risk of mental disorders, the emergence delirium, confusion, delirium disorders. Ascorbic acid in combination with means Lidevin reduces patient's response to alcohol.

There are also reviews of Lidevin, that it increases the toxicity of drugs whose metabolism occurs in the liver (e.g., diazepam, phenytoin, antipyrine, chlordiazepoxide).

Instructions for use Lidevin

 Lidevin pills
 Lidevin taken orally two p / day for 0, 125-0, 5g (counting on disulfiram). After a week or 10d. carried ethanol disulfiramnuyu sample: receiving 0, 5g Lidevin and thereafter - 20-30ml 40% ethanol and define response. If the response was weak, increase the amount of ethanol in the 10-20ml (maximum dosage of 100-120ml ethanol 40%) achieving a standard ethanol-producing disulfiramnoy reaction. Repeat the sample should be c / o one or two days in the hospital, and after 3-5dn. in an outpatient setting, adjusting the dosage or ethanol Lidevina necessary. After the patient is over 1-3h years. on maintenance therapy, taking 0, 125-0, 2g / day.

Take Lidevin recommended by 12-24ch after the last use of alcohol.

side effects

Lidevin can cause an unpleasant smell from the mouth (in patients with colostomy), taste "metal."

There are reviews of Lidevin, provokes the development of hepatitis, gastritis, neuropsychiatric disorders, polyneuritis of lower limbs, memory loss, disorientation in space, headache, allergic skin reactions, asthenia.

Additional instructions Lidevin indicated that the compound of ethanol with disulfiram can cause arrhythmia, collapse, infarction, angina, cerebral edema, hemorrhagic stroke.

Possible overdose Lidevina causing coma, collapse, neurological complications. To eliminate symptoms used standard therapy aimed at maintaining and restoring respiratory and cardiovascular systems.

Contraindications

Lidevin can not be used when: thyrotoxicosis, expressed cardiosclerosis, atherosclerosis of brain vessels, in pre-and post-infarction states, in case of hypersensitivity, arterial hypertension 2-3y extent, other urological diseases of the cardiovascular system, with severe coronary insufficiency, pulmonary tuberculosis, accompanied by hemoptysis, bronchial asthma , severe pulmonary emphysema.

Also, do not prescribe Ledivin erosive lesions in the gastrointestinal mucosa, gastrointestinal ulcers, kidney failure, liver, diabetes mellitus, epilepsy, and other neuropsychiatric pathologies, infections of the nervous system, neuritis of the visual, auditory nerves, polyneuritis, malignant tumors, glaucoma, during lactation , pregnancy.

The instructions Lidevin stated that caution should be taken medication: elderly patients after 60l, patients with endateriitom, circulatory disorders of the brain, psychosis provoked by disulfiram (in the past), gastrointestinal ulcers in remission.

If Lidevin administered with anticoagulants is necessary to control the amount of prothrombin and adjust the dose of anticoagulants, as there is a risk of bleeding.

During therapy, it should be noted that the action Lidevin increase isoniazid, metronidazole, tricyclic antidepressants (eg, amitriptyline). The simultaneous use of Lidevinom isoniazid can cause behavioral disorders, motor coordination, phenytoin increases the risk of side effects, and tinidazole, ordinazol, metronidazole, seknidazol - the risk of mental disorders, the emergence delirium, confusion, delirium disorders. Ascorbic acid in combination with means Lidevin reduces patient's response to alcohol.

There are also reviews of Lidevin, that it increases the toxicity of drugs whose metabolism occurs in the liver (e.g., diazepam, phenytoin, antipyrine, chlordiazepoxide).





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