Levodopa (lat. Levodopa) - a drug used in clinical practice for the treatment of Parkinson's disease and symptomatic parkinsonism.
It belongs to a group of pharmacological agents and of anti-Dofaminomimetiki funds. It is a combination of a precursor of dopamine, an inhibitor of peripheral dopa decarboxylase and COMT inhibitor.
The active ingredient is levodopa.
Pharmacological influence Levodopa
The positive effect of enabling to reduce symptoms of Parkinson's disease and symptomatic parkinsonism occur because the active ingredient of the drug is converted to dopamine directly into the central nervous system of the body, filling its deficiency there. The predominant part of the dopamine formed in peripheral tissues and is involved in promoting the implementation of antiparkinsonian effect of levodopa. It does not get into the central nervous system and is a major cause of side effects of levodopa.
To reduce the dose of levodopa in the body the drug administered in combination with inhibitors of peripheral dopa-decarboxylase. This also helps to reduce adverse side manifestations of the drug.
Levodopa can eliminate:
According to the instructions, levodopa prescribed for the treatment of Parkinson's disease symptoms and symptomatic parkinsonism (except when it is called antipsihicheskih taking drugs).
Levodopa is contraindicated in the following cases:
- the presence of individual hypersensitivity to the components of Levodopa;
- If the patient is taking MAO inhibitors;
- women during pregnancy and lactation;
- children under 12 years of performance.
Subject to security measures of levodopa may be appointed at:
- presence of pulmonary diseases and diseases of the liver, heart, vascular and endocrine systems;
- manifestations of psychosis in a patient;
- angle-closure glaucoma (including the predisposition thereto);
- open-angle glaucoma, chronic flowing form;
- hepatic and / or renal failure;
- melanoma (and history);
- manifestations of central nervous system depression;
- recurrent seizures;
- gastric ulcer, duodenal ulcer;
- Myocardial infarction (including a history including at flowing parallel manifestations arrhythmias of various types);
- heart rhythm disorders.
Levodopa Instructions: Method of application and dosage
Take the drug orally, gradually increasing the dose of Levodopa from minimum to maximum in each case (depending on the individual characteristics of the patient). The capsules are swallowed with a little liquid with meals.
The minimum dose is from 0 25 to 1 g, taken as 2 or 3 times.
Increase the dose of 0, 125-0, 75 g at regular intervals (two to three days), focusing on individual tolerability parameters Levodopa body, until the moment when it begins the optimal therapeutic effect is observed.
The maximum daily dose should not exceed 8g.
Stop taking the drug gradually.
Possible side effects of the drug
The instructions to levodopa lists a number of side effects that can cause reception of the drug.
On the part of the gastrointestinal tract are possible symptoms of nausea, vomiting, loss of appetite, dysphagia, ulcer formation of wounds on mucous membranes of the stomach and intestines, gastrointestinal bleeding, gastralgia.
The nervous system can respond to levodopa different sleep disorders, symptoms of anxiety and / or depression, dizziness, symptoms of paranoid states, hypomania, euphoria, dementia, ataxia, seizures, movement disorders (including the occurrence of uncontrolled motor movements).
From the heart and blood vessels may occur the following violations: reduction in blood pressure, orthostatic collapse, arrhythmia, tachycardia.
The organs of hematopoiesis may arise leukopenia and thrombocytopenia.
It may develop polyuria, in rare cases - diplopia.
Guide to levodopa warns of threat to health of the patient with a sharp termination of the course of treatment. In this case develops symptoms similar to that caused by neuroleptic malignant syndrome (including fever, mental disorders, increasing activity of CK in the serum).
In cases where it is impossible to avoid levodopa dose reduction or withdrawal of treatment, continuous monitoring of the patient (especially in cases where the treatment is accompanied by still taking drugs antipsihicheskogo action).
If you want to transfer to combination therapy comprising in combination of levodopa and an inhibitor of peripheral dopa decarboxylase, the drug must be canceled 12 hours before the appointment of an inhibitor of peripheral dopa decarboxylase.
The tool may not be imposed for disposal of extrapyramidal reactions.
When levodopa is not recommended intake of protein-rich food, because it reduces the level of absorption of the drug.
During the course of treatment requires constant monitoring of blood parameters and operation of the various organ systems.
It wanted to be careful when driving vehicles and in cases where the patient is engaged in potentially hazardous work.
Store this medication should be at a temperature not exceeding 30 degrees in a dry, sheltered from direct sunlight.
Pharmacies Levodopa prescription.