Lamictal belongs to the clinical and pharmacological group of anticonvulsant drugs.
The pharmacological action of Lamictal
In the medical field Lamictal mainly quoted as an antiepileptic agent. Contained in the formulation of lamotrigine for blocking voltage-dependent sodium channels. Thanks to this component in the culture of neurons occurs voltage-dependent blockade, which implies a continuous repetition of impulses, as well as the suppression of abnormal release of glutamic acid, which is very important in the development of epileptic seizures.
Reviews Lamiktale confirm the efficacy of the drug and as a means of preventing mood disorder that can occur in patients with bipolar disorder. This role Lamictal has been demonstrated in 2 clinical studies of the fundamental. Thanks to the combined analysis of the results obtained during the study, we can say for sure that the duration of remission in a group of lamotrigine much longer as compared to placebo. Whereby patients with depression after taking Lamictal duration of remission more pronounced.
Lamictal dosage form are:
- light yellow-brown tablets which have rounded corners and lettering "GSEC7" »(25, 50 and 100 mg);
- soluble / chewable tablets white or almost white, have a pleasant smell of black currant (5, 25 and 100 mg).
Indications for receiving Lamictal
For each age group indications for use of the drug may be different.
For children who are older than 12 years, and adults receiving Lamictal is shown in monotherapy or in combination therapy in epilepsy.
Instruction Lamiktalu claims that for children aged 2 to 12 years, the main indication is epilepsy, the treatment of which the drug is used only as part of combination therapy. As a single agent used in typical absence seizures.
When bipolar disorder taking the drug indicated for adult (18 years) in order to prevent any mood disorders including hypomania, mania, depression and mixed episodes.
Lamictal is contraindicated in patients who have a hypersensitivity to any component of the drug.
Instructions Lamictal: methods of use
Dosing of the drug can be installed solely on an individual basis by the attending physician.
Typically, in the treatment of epilepsy initial dose Lamictal monotherapy is 25 mg, which are received only 1 time per day for 2 weeks (with subsequent possibility of increasing dose). To achieve the desired therapeutic effect, some patients may require about 500 mg per day, but this is a maximal dose.
In combination therapy technique Lamictal tell you how to start with a dose of 25 mg, which must be received within 2 weeks, within the next two weeks, increasing the dose is not recommended, and then every week or two, you can increase the dosage of 25-50 mg day.
In patients with epilepsy receiving Lamictal, reviews confirm this, may be accompanied by negative consequences:
- subcutaneous fat and skin (rashes, toxic epidermal necrolysis);
- lymphatic system and of the blood (neutropenia, agranulocytosis, leukopenia, aplastic anemia, anemia, pancytopenia, thrombocytopenia);
- the immune system and psyche (hypersensitivity syndrome, irritability, aggression, hallucinations, tics, confusion);
- central nervous system (insomnia, drowsiness, tremors, dizziness, ataxia, headaches);
- senses (blurred vision, diplopia, conjunctivitis);
- digestive system (nausea, diarrhea, vomiting, liver failure, liver dysfunction);
- connective and muscular tissue (lupus-like syndrome).
Among other reactions may be noted fatigue.
Patients with bipolar disorder receiving Lamictal may be accompanied by negative reactions from:
- CNS (dizziness, drowsiness, agitation);
- Skin (rash, Stevens-Johnson syndrome);
- digestive system (dryness of the oral mucosa);
- connective and muscular tissue (arthralgia).
Among other side effects may be noted backache.
Conditions and terms
Lamictal should be stored in a dark, dry place for no longer than 3 years.