Kortef

 Anti-inflammatory drug Kortef
 Kortef - anti-inflammatory drug.

Pharmacological action

Kortef is a synthetic analogue of the natural endogenous hormone secreted by the adrenal glands. It has anti-inflammatory effect, is effective in endogenous hormone deficiency affects the immune response.

Product form

Producing powder, solution, suspension Kortef.

Indications Kortefa

Kortef used to remove the patient from toxic, traumatic, burn, cardiogenic, operational shock in cases where the standard antishock therapy failed.

Effective drug in eliminating the symptoms of allergic reactions, anaphylactic shock and blood transfusion, it is used for the prevention of inflammation and scarring in the burn cauterizing liquids.

The instructions Kortefa indicated that it can appoint a cerebral edema caused by the operation, the tumor, radiation, or chemotherapy, or on any other grounds; bronchial asthma severe; rheumatoid and gouty arthritis; acute hepatitis; acute adrenal insufficiency; tireotoksicheskom Stroke; hepatic coma, bursitis, osteoarthritis, epicondylitis, tenosynovitis, dark red erythematosus, acute rheumatic heart disease, polymyositis.

In dermatology Kortef used to treat dermatitis herpetiformis bullous, severe seborrheic, exfoliative, contact and atopic, severe psoriasis, mycosis fungoides, erythema multiforme in the severe stage, pemphigus.

In ophthalmology Kortef prescribed for allergic conjunctivitis, keratitis, eye disease when infected with herpes zoster, allergic corneal ulcers, inflammation of the anterior segment of the eye, iridocyclitis, iritis, chorioretinitis, ocular neuritis, posterior uveitis and horioidita.

In oncology Kortef used to treat leukemia in children, Lymphoma and leukemia in adults.

In pulmonology used drug for the treatment of berylliosis, aspiration pneumonia, Loeffler's syndrome, which can not be cured with the help of other drugs, pulmonary tuberculosis: Kortef combined with drugs for tuberculosis.

Instructions Kortefa: how to use

 Kortef tablets
 For emergency care in acute conditions should enter Kortef intravenously. Begin treatment with a dose of 100 or 500 mg, followed by the drug is administered again every 2-6ch as long as necessary to stabilize the condition, usually not longer than 2-3 days.

Kortef depot is administered in the form of the blockade: in the knee, hip and shoulder joints prick 25-50mg (or 100 mg in acute conditions), in the interphalangeal, elbow and wrist joints prick 10-20mg. Procedure was repeated every 1-3 weeks, in some cases - every 3-5 days.

Babies with the introduction into the joints Kortefa shows such dosages: aged 3-12mes - 25mg, 1g-6L - 25-50mg, 6-14l - 50-75mg.

If Kortefa be introduced intramuscularly, acceptable daily dose is 125-250mg if inside, the initial dose is 20-240mg.

For the treatment of the acute phase of multiple sclerosis are administered 800 mg / day during the week and 320mg / day for a month.

Discontinue treatment with Kortef gradually, otherwise the disease may worsen.

Side effects Kortefa

During treatment with Kortef may experience muscle weakness, high blood pressure, fluid retention and sodium, osteoporosis, reduced muscle mass, loss of potassium, tendon rupture, vertebral fractures of long bones, necrosis of the humeral head, femur, flatulence, ulcerative esophagitis, pancreatitis , slow regeneration of the wound surface, weakening the skin, erythema of the skin on the face, sweating, petechiae, increased intracranial pressure, headache, cramps, dizziness, Cushing's syndrome, menstrual disorders, latent diabetes and increase the need for insulin, growth retardation in children, glaucoma, increased intraocular pressure, posterior subcapsular cataracts, ezoftalm.

Contraindications

Kortef not be taken in the presence of systemic fungal infections, hypersensitivity.

Use for the treatment Kortef during pregnancy or while breastfeeding is possible only after medical consultation. If the drug was administered to a pregnant woman, the baby after birth should be examined for the presence of adrenal insufficiency.

Phenytoin, phenobarbital, rifampin may increase the clearance rate Kortefa and reduce its rate of excretion of the active ingredient ketoconazole and oleandomycin.

Additional instructions Kortefa indicated that it affects the action of anticoagulants, so it is necessary to monitor the performance of blood clotting.

Be wary appoint Kortef simultaneously with aspirin in patients with gipoprotrombinemiey.





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