Kordafleks - pharmacological agents from the group of antihypertensive drugs used in the treatment of hypertension. The active substance - nifedipine.
Structure and Composition
According to the instructions issued in the form Kordafleks retard tablets (sustained release), 10 and 20 mg.
Furthermore nifedipine tablet composition includes auxiliary components (magnesium stearate, polyvinyl butyral, talc, croscarmellose sodium, hydroxypropylcellulose, lactose monohydrate, MSC).
In package 100 tablets.
Pharmacological action Kordafleksa
This drug has an antihypertensive and anti-anginal (analgesic) effect. Kordafleks relates to calcium channel antagonists and slow transfer of calcium ions across cell membranes in cardiac muscle and in vascular smooth muscle.
Kordafleks indicated for the treatment of hypertension (including hypertensive crisis cupping), with ischemic heart disease prevention and relief of angina attacks. This drug is used in treatment of chronic heart failure. Kordafleks shown as a part of complex therapy for Raynaud's syndrome.
Hypersensitivity to nifedipine or other ingredients of the drug, the first trimester of pregnancy. Also according Kordafleks instructions should not be used during the first 8 days after acute myocardial infarction.
Dosing and Administration
Selection of the dosage is done individually by the attending physician. Typically Kordafleks administered 10 mg three times a day (daily dose 30 mg).
In acute attack of angina has arisen (or hypertensive crisis) tablet formulation of the need to chew and keep the mouth to complete resorption.
The minimum interval between doses Kordafleksa of instructions at least 2 hours.
Dosage of 20 mg is usually given to adults with persistent hypertension for prolonged use. In this case 20 mg of the drug must be taken 1-2 times per day. In the opinion of Kordafleks effectively reduces blood pressure and acts for a long time.
Side effects Kordafleksa
When you receive this drug may experience the following symptoms: headache, flushing of the face, a feeling of warmth, increased heart rate,
dizziness, hypotension. In the opinion of Kordafleks can cause similar symptoms, early treatment, and they are mild and go away within a few days. Very rarely the drug after prolonged use can cause inflammatory changes of gums (gingivitis), in patients elderly rarely celebrated gynecomastia. All of these states are themselves after discontinuation of the drug. Rare side effects such as a temporary increase in blood glucose.
Overdose Kordafleksom causes intoxication, and the following symptoms: dizziness, headache, retrosternal pain, hypotension (low blood pressure), tachycardia (rapid heart rate), bradycardia (slowing of the heart rate), depression of activity of the sinus node
. In severe overdose, possible unconsciousness, arrhythmias
. Kordafleksa specific antidote does not exist
. Treatment is aimed at addressing the symptoms
. With early diagnosis overdose therapy begins with gastric lavage and receiving enterosorbents (activated charcoal)
. In overdose Kordafleksa Review quickly helps to improve the patient's condition introduction of a 10% calcium chloride (or gluconate)
. In case of symptoms of heart failure shows the introduction of cardiac glycosides (strophanthin, digoxin)
. Also, in case of overdose Kordafleksom shown to check blood sugar and electrolytes (calcium, potassium)
Interaction Kordafleksa with other drugs
Kordafleks of instructions increases the effect of other antihypertensive agents. In the case of simultaneous use it with quinidine requires caution, since there may be changes in the electrocardiogram (prolongation of the interval QT, ventricular arrhythmias occur).
It is also known that the drugs enhance the effect of ACE blockers Kordafleksa.
Application Kordafleksa should be administered under medical supervision with a personal touch. Reception mode of the drug is selected depending on the effect and the severity of the disease.
In case of severe heart disease treatment should begin with the preparations of other pharmacological groups. During treatment Kordafleks can be combined with cardiac glycosides.
Precautions should use the drug in patients with severe heart failure.
At the beginning of the application Kordafleksa must be careful when driving vehicles and operating machinery.