Klindatsin

 Vaginal creams and pessaries Klindatsin.
 Klindatsin - antibiotic belonging to the group of lincosamides and active against a broad range of pathogens. Release form of the drug determines its use especially of the fair sex.

Product form

Klindatsin is available in two dosage forms: vaginal cream and vaginal suppositories same (they are candles).

The cream is white with a slight yellowish tinge pumpable substance placed in aluminum tubes 20 and 40 In addition to the tube of a medicine embedded in a secondary package also special applicators (respectively 3 or 7, depending on the amount of cream in the tube) of installation the cream into the vagina. The concentration of active substance (in his role as advocates clindamycin) is 2%, ie 2 mg per 1 g produced this formulation oldest Russian pharmaceutical company "Akrikhin."

Vaginal suppositories are similar to cream color, put up at the rate of three candles in one individual package. The content of clindamycin is 100 mg per candle. Klindatsina manufacturer in the form of vaginal suppositories is LLC "Farmaprim" (Moldova), and the candles are packaged in the same domestic quinacrine.

Analogs Klindatsina

Speaking of analogues Klindatsina should immediately mention his American "brother": drug Dalatsin of "Pharmacy and Upjohn campaign" .  In addition to creams and suppositories Dalatsin produced also in gel form for topical application .  Here are the rest of analogues Klindatsina: Polish Klindatop from "Elfy" (gel for external use), the domestic production of Clindamycin Company "Vertex" (vaginal cream) and Hungarian Klindeks the famous "Gedeon Richter" (cream for external use) .  It should be noted that all of these drugs have the same (cream, suppository) or similar structure (gel) dosage form as Klindatsin .  If we proceed from the principle of equivalence of pharmacologically active ingredient, the analogs can be written Klindatsina and other dosage forms of clindamycin: this is the original "pfayzerovskie" Dalatsina capsule and the solution Dalatsina phosphate (producing country - Belgium), as well as solution and capsules Clindamycin from "Hemofarm "(Serbia) .

Pharmacological action

Clindamycin has bacteriostatic (does not destroy, and inhibits the development of) action, although in high concentrations can and bactericidal effect. Penetrating into the bacterial cell, the antibiotic inhibits protein synthesis, which prevents microorganism properly grow and develop. The spectrum of action of the drug extends over a wide range. Klindatsin active against certain species of staphylococci and streptococci. It is effective for bacterial vaginosis caused by Gardnerella, mobiluncus, bacteroids, mycoplasma, certain types of clostridia. According to the reviews of Klindatsine practitioners, the drug has no effect on Trichomonas and Candida, and has cross-resistance with lincomycin.

Indications

Instruction Klindatsinu terse: the drug is used at dysbacteriosis vagina (alternative names - bacterial vaginosis or vaginal dysbiosis), caused by sensitive pathogens. For reference: the vaginal bacteria overgrowth develops when replacement lactoflora vagina aggressive associations microbes.

According to the reviews of Klindatsine, if the infectious agent is bacteria of the genus Clostridium, it is necessary to conduct bacteriological research bioassays patient (crop smear on the diet) with definition of sensitivity to antibiotics seeded microflora.

Regulations on the use of Klindatsinu

 Klindatsin cream for intravaginal applicator.
 Cream inserted into the vagina using the previously mentioned one-time applicator package insert with the medicine. This manipulation is described in detail and illustrated in the instructions to Klindatsinu. It poses no difficulty: the applicator is screwed onto the neck of the tube is filled with a cream (necessary to press on the tube itself, rather than delay the applicator piston) and inserted into the vagina as shown in the image in the manual. Applicator help in dispensing the drug. Single dose Klindatsina a cream is 100 mg, ie one completely filled applicator. The most convenient way to install a medicinal cream into the vagina at bedtime. The duration of treatment ranged from three to seven days.

Before introduction into the vagina, the candle is extracted from the contour of packaging that must be cut with scissors along the contour of the cell with a candle. The introduction should be as deep, which is easiest to do in the supine position. Frequency of administration and duration of treatment is the same as in the case of cream.

Contraindications

Negative reviews Klindatsine bit. There (very rare) idiosyncrasy clindamycin (it is more likely in the presence of it, and against lincomycin). Klindatsin not recommend taking the first three months of pregnancy. In the future, given the fact that clindamycin has the ability to cross the placenta into the bloodstream of the fetus, receiving Klindatsina justified only if the potential benefit of the drug outweighs the potential risk. This is true for breast-feeding women. Reviews of Klindatsine against its use in children is not mentioned, its efficacy and safety for them to be confirmed.

side effect

Reviews Klindatsine talk about its good tolerability. In some cases possible:

  • allergic reactions in the form of itching, hives, rashes;
  • from the urogenital tract - cervicitis (inflammation localized in the cervix), colpitis (inflammation of the vagina), irritation of the external genitalia;
  • very rare - abnormal blood parameters (neutropenia, agranulocytosis, eosinophilia, thrombocytopenia).

Systemic effects of the drug (as, in fact, unique Klindatsina) is weak, and in some cases may develop symptoms of pseudomembranous enterocolitis (frequent bowel movements, abdominal pain, rapid heart rate), which sometimes happens on the background of some antibiotics.

Reviews of Klindatsine associated with its overdose, have been reported.

Cautions

If Klindatsin applied systematically, it is possible to create favorable conditions for the growth of Candida, which, as noted above, are not sensitive to this drug.

If you have any diarrheal illness (including diarrhea) on the application should temporarily refrain Klindatsina.

The drug is better not to be combined with other means of intravaginal and apply his solos that applies to candles and a cream.

According to the instructions Klindatsinu cream prescription candles - without him.

Instructions for storage Klindatsinu

Temperature storage of cream and suppositories somewhat different: the first - it's up to 20? C, for the second condition is the optimal temperature range of 15 to 25? C. Place of storage, of course, it should be possible reach of children. Shelf life - 3 years, after which the drug is not recommended.





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