Ketorolac

 Ketorolac Tablets

Ketorolac is a nonsteroidal anti-inflammatory drug used in moderately and strongly expressed painful syndrome.

Pharmacological action

Ketorolac has pronounced analgesic, antipyretic moderate, anti-inflammatory and antiaggregatory (prevents platelets from sticking together) properties.

The active ingredient of the drug is ketorolac tromethamine. The mechanism of action of this substance is due to its ability to inhibit the enzyme activity, which is a precursor of prostaglandins, which play a central role in the mechanism of the origin and development of pain, inflammation and fever.

Ketorolac maximum blood concentration is observed after 40-50 minutes after intramuscular administration, or oral administration.

The half-life of the drug - 4-6 hours. Since about 90% of Ketorolac excreted in the urine, in the elderly, and persons suffering from renal impairment, while excretion increased.

Indications

Use Ketorolac guide recommends to reduce pain and inflammation with injuries, sprains, dislocations, cancer, dental pain, pain in the postoperative and postpartum, neuralgia, muscle pain, sciatica, pain in the joints, rheumatic diseases.

Ketorolac expedient purposes only symptomatic therapy on the progression of the disease the drug is not affected.

Instructions for use Ketorolac

 Ketorolac in ampoules
 For convenience Ketorolac is available in tablet form and as a solution for intramuscular injection. Ketorolac is recommended to take tablets at intervals of 4-6 hours for 1 piece. (10 mg ketorolac tromethamine). If necessary, a single dose may be increased to two tablets. Ketorolac used in ampoules for intramuscular administration: 10-30 mg every 4-6 hours. Duration of ketorolac should not exceed 5 days. The day Ketorolac in ampoules or in the form of tablets should not be used more than 90 mg and for patients older than 65 years, as well as violations of the liver and body weight less than 50 kg - more than 60 mg.

Side effects

Solution for injection and tablets Ketorolac can trigger:

  • changes in blood pressure, bradycardia (low heart rate), fainting;
  • abdominal pain, nausea, dyspepsia (indigestion), diarrhea, constipation, dry mouth, vomiting, flatulence, stomatitis, abnormal liver function, erosive and ulcerative lesions of the digestive tract;
  • headache, anxiety, drowsiness, depression, sleep disorders, euphoria, dizziness, blurred vision, change in taste;
  • asthma attacks, respiratory failure;
  • frequent urination, hematuria (blood in the urine above the norm), decrease in urine volume, nephrotic syndrome, acute renal failure;
  • elongated clotting time, thrombocytopenia, epistaxis, postoperative bleeding;
  • hyponatremia, hypokalemia, elevated levels of urea and creatinine in the blood;
  • muscle pain, hives, itchy skin;
  • pain at the injection site.

Contraindications to the use of Ketorolac

According to the instructions, Ketorolac is not indicated for:

  • hypersensitivity to ketorolac tromethamine, aspirin and other nonsteroidal anti-inflammatory drugs;
  • nasal polyps;
  • asthma;
  • bronchospasm;
  • angioedema;
  • ulcerative lesions of the digestive tract;
  • a decrease in blood volume (hypovolemia);
  • impaired renal function;
  • dehydration;
  • incomplete hemostasis, or a high risk of bleeding after surgery;
  • bleeding in the brain;
  • violation of hematopoiesis.

Ketorolac in ampoules, as well as in the form of tablets is contraindicated in women who bear children, or breastfeeding, as well as patients under the age of two years.

Additional Information

Keep Ketorolac guide recommends in a dark place with temperatures 15-25 0 C. The solution for injection and tablets Ketorolac if stored properly remains fresh for 2 years from the date of issue.





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