Ketoprofen

 Ketoprofen
 Ketoprofen is a non-steroidal anti-inflammatory drug used for the symptomatic treatment of arthritis and acute pain.

Pharmacological action

Ketoprofen has anti-inflammatory, analgesic, antipyretic properties but also inhibits platelet adhesion.

The therapeutic effect of Ketoprofen is due to its ability to inhibit the synthesis of an enzyme involved in the synthesis of prostaglandins and reduce the biosynthesis of prostaglandins directly responsible for the appearance of swelling and pain in the inflammation. Application Ketoprofen allows ease the pain in the joints when in rest and in motion, to reduce morning stiffness and swelling of the joints, increase range of motion.

Ketoprofen anti-inflammatory effect can be observed at the end of the first week of treatment. The maximum drug concentration in the blood is achieved in 15-30 minutes after the application of ketoprofen injectable 1-4 hours after administration and rectal suppositories 1-2 hours after oral administration. Ketoprofen is derived mainly kidneys, and about 1% - the intestines.

Indications Ketoprofen

Assign User Ketoprofen recommends that:

  • symptomatic treatment of chronic inflammation of the joints (arthritis): rheumatoid arthritis (destruction of bone, cartilage), psoriatic arthritis (inflammation of the joints on the background of psoriasis), ankylosing spondylitis (a disease of the spine), gout (joint disease in which tissues are deposited in the salt of uric acid) , arthritis pain syndrome;
  • symptomatic treatment of diseases of the musculoskeletal system, with inflammatory and degenerative: tendinitis (inflammation of the tendon tissue), tenosynovitis (inflammation of the tendons around the protective membrane), lumbago (Acute pain), bursitis (inflammation of the mucous bags in the joints);
  • symptomatic short-term treatment of acute pain: neuralgia, back pain, muscle pain;
  • complex therapy of inflammatory diseases of the lymph nodes, lymphatic vessels, veins: lymphangitis (inflammation of the lymphatic vessels), superficial lymphadenitis (inflammation of the lymph nodes), periphlebitis (inflammation okolovenoznoy tissue and veins), phlebitis (inflammation of the vein wall).

Ketoprofen gel is used for sports injuries uncomplicated, tears or sprains of ligaments and tendons, ligaments and muscle injuries, post-traumatic swelling and pain.

Contraindications

According to the instructions, ketoprofen is not indicated for:

  • severe violations of liver or kidney function;
  • peptic ulcer exacerbation;
  • inflammatory bowel disease;
  • blood coagulation disorders;
  • hypersensitive to ketoprofen or other non-steroidal anti-inflammatory drugs.

Ketoprofen is contraindicated in the third trimester of pregnancy, lactation, children under 14 years.

Ketoprofen candles are not assigned when proctitis (inflammation of the lining of the rectum and sigmoid) and proktorragii (bleeding from the anus).

Ketoprofen Ointment should not be used for eczema (skin rash), weeping dermatoses and infected wounds.

Be wary of Ketoprofen manual recommends bronchial asthma, anemia, liver disease, alcoholism, sepsis, edema, congestive heart failure, stomatitis, hypertension, diabetes, ulcerative lesions of the gastrointestinal tract in history. Application of Ketoprofen in the first and second trimester of pregnancy is possible only under strict indications.

Instructions for use Ketoprofen

For oral administration, Ketoprofen, the use of which allows the combination of several dosage forms, available as tablets, prolonged action tablets, drops, capsules, granules.

Drops and Tablets Ketoprofen should be taken with food 3 times a day 100 mg. Ketoprofen retard tablets (sustained release) are assigned to 150 mg every 12 hours. Preparation capsule taken in the morning and in the afternoon with 50 mg in the evening - 100 mg. Ketoprofen Granules guide recommends taking 2-3 times a day to 80 mg (1 packet). Single dose for children and older people corresponding to 40 mg. Before taking a sachet dissolved in ½ cup of water.

Candles Ketoprofen administered into the anal passage a dose of 100 -200 mg daily.

Intravenous and intramuscular use Ketoprofen involves injecting 1-3 times a day to 160 mg.

 Ketoprofen gel
 For topical use, creams and gel Ketoprofen. Apply the gel and ointment Ketoprofen children over 12 and adults is recommended 2-3 times a day in small amounts (3-5 cm). After the application of ketoprofen gel and ointment should be long and gently rub into the painful or inflamed areas of the body. Children 6-12 years of ketoprofen gel is prescribed to use not more than 2 times a day for 1-2 cm.

Without a doctor's advice to use the gel and ointment Ketoprofen longer than two weeks is not recommended.

Side effects

Suppositories Ketoprofen Tablets and other forms of the drug, for oral and parenteral use may cause undesirable reactions such as:

  • abdominal pain, flatulence, heartburn, vomiting, nausea, diarrhea, loss of appetite, abnormal liver function, stomatitis;
  • dizziness, nervousness, agitation, depression, drowsiness, headache, confusion;
  • blurred vision, tinnitus, hearing loss, eye pain, conjunctivitis;
  • increased blood pressure, tachycardia;
  • leukopenia (reduction in white blood cells), anemia (low levels of red blood cells or hemoglobin), thrombocytopenia (reduced platelet count), agranulocytosis (disappearance of the blood granulocytes);
  • edematous syndrome (accumulation of excess fluid in the body), urethritis (inflammation of the urethra), cystitis (bladder infection), nephrotic syndrome (a kidney disease, which is characterized by urinary excretion of large amounts of protein), renal failure;
  • itching, skin rash, rhinitis, bronchospasm, angioedema;
  • sweating, nosebleeds, coughing up blood, thirst, shortness of breath.

With prolonged use of ketoprofen can cause expression of the mucous membrane of the digestive tract, gastrointestinal, vaginal, hemorrhoids, gingival bleeding.

Ketoprofen gel and ointment may cause redness of the skin (large red spots on the skin), purple (staining of the skin as a result of the output of red blood cells from the capillaries), skin rashes, photosensitivity (sensitivity to UV rays), itching, burning, and other allergic reactions.

Additional Information

Store Ketoprofen Tablets, and other forms of the drug should be at room temperature. Shelf life of solution for injection - three years, all other formulations - 5 years.





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