Kandibene - pharmacological agents from the group of antifungal agents.
Structure and Composition
The active ingredient - clotrimazole.
Kandibene available as creams, vaginal suppositories and solution for outdoor applications.
Clotrimazole cream contains Kandibene and auxiliary components (benzyl alcohol, sorbitan monostearate, polysorbate, tsetilstearinovy alcohol, cetyl palmitate, 2-octyldodecanol, water). The cream is available in tubes of 30g, it is almost white, homogeneous, odorless.
Vaginal suppositories Kandibene contain 100 or 200 mg of clotrimazole and auxiliary components (corn starch, lactose monohydrate powder, adipic acid, sodium bicarbonate, magnesium stearate, colloidal silicon dioxide, polysorbate). Candles are available for 3 pieces. in blister. The package 1 or 2 blisters with the drug, complete with applicator.
Topical solution contains Kandibene clotrimazole 1 g per 100 g solution. Furthermore clotrimazole the product contains excipients (benzyl alcohol, propylene glycol, polyethylene glycol). Solution for external application is available in dark glass bottles of 40 ml.
Pharmacological action Kandibene
This drug has a broad spectrum of antifungal activity. Clotrimazole violates the synthesis of the substance, which is part of the cell membrane of fungi. As a result of the drug occurs lysis of fungal cells.
In small doses Kandibene has fungistatic effect, in large - fungicide. According to the instructions Kandibene effect on dermatophytes, yeast and mold fungi, and agents of multi-colored lichen and erythrasma. This drug has antimicrobial activity against staphylococci, streptococci, and Gram-negative bacteria (Bacteroides, gardenerella).
Through the skin and mucous Kandibene poorly absorbed and has no systemic effects. For external use drug concentration is higher in the epidermis than in the deeper layers of the skin and subcutaneous tissue. However, that concentration is created in the deep layers of the skin is enough to suppress growth of dermatophyte fungi.
According to the instructions Kandibene recommended for use in fungal diseases of the skin, athlete's foot and skin folds erythrasma, pityriasis versicolor, candidiasis (caused by dermatophytes, molds and yeast), and fungal infections, complicated by secondary pyoderma. Also, this drug is indicated for vulvovaginal candidiasis, trichomoniasis, genital when superinfection and for the rehabilitation of the genital tract before delivery.
- hypersensitivity to the ingredients of the drug;
- first trimester of pregnancy.
Precautions need to use this medication while breastfeeding.
Use during pregnancy and lactation
Ongoing clinical studies have not established the facts of negative effects on the fetus during pregnancy and the health of the woman. However, the possibility of the appointment should be decided individually Kandibene doctor.
During lactation it found that the drug does not penetrate into breast milk. But the use of the drug topically to the mammary glands during lactation is contraindicated.
Dosing and Administration Kandibene
The medicament in the form of a solution is a cream and topically. The cream is applied in a thin layer on the dry and cleaned the affected areas of the skin, and rub lightly.
Cream Kandibene used 2-3 times a day. The duration of treatment depends on the severity of the disease, the localization of the pathological process, and the sensitivity to the treatment. When ringworm treatment should be at least 4 weeks with pityriasis versicolor - up to 3 weeks.
The treatment of fungal infections of the skin of feet should be carried out even 2 weeks after symptoms resolve.
Suppositories Kandibene be inserted deep into the vagina at night before bedtime. The course of treatment is 6 days (candles 100 mg) or 3 days (candles 200 mg).
For the purpose of rehabilitation of the birth canal should be used Kandibene as vaginal suppositories once.
When using Kandibene possible local reactions in the form of itching, burning, stinging. When applying the cream may cause erythema, blisters, irritation, flaking, edema. Also, you may experience an allergic reaction (hives, itching). In the opinion of Kandibene rarely causes side effects and is well tolerated by patients.
In the opinion of Kandibene not cause any adverse reactions and conditions when applied in high dosages.
Interaction with other drugs
When using Nystatin, Natamycin and Amphotericin marked decrease in efficiency Kandibene.
Special instructions for use Kandibene
According to the instructions Kandibene should not be applied to the skin around the eyes, in contact with the eyes must be rinsed with plenty of running water.
In the treatment of onychomycosis should be noted that processed the nail plate should have a rough surface for better penetration of the drug. In the opinion of Kandibene in these cases it is best to use as a solution.
Patients with symptoms of liver failure in the treatment of drug Kanibene should periodically monitor the condition of the liver.
In the absence of effect of the treatment for 4 weeks should be a re-confirmation of the diagnosis.
When symptoms of increased sensitivity or irritation should be discontinued Kandibene.