Kanamycin

 Kanamycin
 Kanamycin - antimicrobials.

Pharmacological action

Kanamycin sulfate - a broad spectrum antibiotic exposure, acid-destroying bacteria, most Gram-negative, gram-positive bacteria, strains of Mycobacterium tuberculosis resistant to streptomycin, isoniazid, p-aminosalicylic acid, drugs against tuberculosis (except florimitsina).

Kanamycin also active against microorganisms which are resistant to erythromycin, tetracycline, chloramphenicol.

Product form

Producing kanamycin sulfate powder for injections for dilution.

Indications

According to the instructions kanamycin is prescribed for severe purulent septic diseases (peritonitis, septic endocarditis, meningitis, sepsis), infectious inflammatory respiratory diseases (lung abscess, pleural empyema, pneumonia), urinary tract infections, kidney purulent complications after surgery, infected burns , tuberculosis and other diseases caused by microorganisms sensitive to kanamycin.

Instructions for use Kanamycin

Enter kanamycin only intramuscularly.

Children drug infections tubercular origin introduced into these daily doses: up to 1st year (prescribed in exceptional cases) - 0, 1g; children 1-5let - 0, 1-0, 3g .; children over 5 years - 0, 3-0, 5 gr. Permissible daily dose - 15 mg per kilogram of body weight. Enter drug 2-3r per day. Treatment continues 5-7dn.

Adults for the treatment of non-tuberculous infection is prescribed to take Kanamitsin to 0, 5g per 8-12ch. At night you can not enter more than 2g., And at a time - more than 1, 0gr. The interval between injections - 12 hours. Duration of therapy - 5-7dn.

 Kanamycin powder
 For the treatment of tuberculosis adult appoint 1 0gr one p / day for children - 15 mg per kilogram of one p / day. The treatment lasts one month or more. During therapy kanamycin administered for six days, every day, on the seventh day make a break.

For dilution for administration intramuscularly, kanamycin sulfate powder was mixed with sterile water for injections (4ml) or p-set novocaine 0, 25-0, 5%.

side effects

Kanamycin can cause diarrhea, allergies, nausea, vomiting, paresthesia, goiter, irritation at the site of injection. Long-term use of the drug can lead to neuritis of the auditory nerve, nephrotoxic reactions.

Overdose antibiotic kanamycin may cause toxic reactions that remove by hemodialysis and peritoneal dialysis.

For parenteral administration may neuromuscular blockade. In this case, and in violation of the patient's respiratory atropine with neostigmine bromide. If necessary, carry out artificial respiration.

Contraindications Kanamycin

According to the instructions Kanamitsin contraindicated in neuritis of the auditory nerve, intestinal obstruction, liver, kidneys, hypersensitive.

Do not give kanamycin premature babies, newborns. During pregnancy, lactation, children under one year is not recommended for the drug without serious health reasons. Older patients drug is prescribed, if you can not use antibiotics that are less toxic.

Do not take kanamycin with monomitsin, florimitsin, neomycin, streptomycin, gentamicin, other jade-ototoxic agents. Also, the drug can not be combined with furosemide and other diuretics.

During therapy, monitor renal function, conduct audiometric control.





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