Kaletra - a drug for the treatment of HIV.
Pharmacological effects of Kaletra
Kaletra - a combination drug with antiviral effect.
The active ingredients of Kaletra - lopinavir and ritonavir. Lopinavir prevents the production of HIV protease. The main purpose of ritonavir - liponavira increase in concentration in the blood.
Kaletra produced in the form of solution for internal use, capsule.
According to the instructions take Kaletra in the complex treatment of children with HIV after two years, adults. Usually connect Kaletra with Combivir, nevirapine, efavirenz.
Instructions for use of Kaletra
Teens and adults taking the drug two p / day during meals - three capsules or 5 ml solution.
Solution Kaletra is recommended to take patients who have problems with swallowing.
The dosage may be increased to 4 capsules two p / day with a combination of Kaletra with nevirapine. Especially, this scheme is effective for patients with reduced sensitivity to lopinavir.
Patients who previously received drugs that suppress HIV drugs, the application of Kaletra and Efavirenz, also take 4 capsules of the drug two p / day.
Babies, after two years, the surface area of the body where 1, 3 sq.m. and more - is prescribed to take two capsules three p / day. Babies, body surface area which is less than 1, 3m.kv. usually prescribe a solution - take two p / day for 230/57, 5mg on sq.m.
One of the most common side effects of Kaletra after - diarrhea.
Also, the drug can cause nausea, abdominal pain, chest, headache, vomiting, asthenia, hyperglycemia, insomnia, skin rash, leukopenia, anemia, lymphadenopathy, Cushing's syndrome, vitamin deficiency, milk acidosis, dehydration, hypothyroidism, increased activity of hepatic transaminases, develop sensitivity to glucose, obesity, edema, weight reduction, sleep disturbances, amnesia, agitation, ataxia, depression, dyskinesia, encephalopathy, impairment of libido, neuropathy, nervousness, paresthesia, disturbances of thought processes, drowsiness, tremors, changes in taste, tachycardia, a violation of pressure increase.
In addition, the instructions given Kaletra are the possible side effects: thrombophlebitis, sinusitis, shortness of breath, dry mouth, pulmonary edema, enterocolitis, dysphagia, bloating, poor appetite, fecal incontinence, stomatitis, acne, hemorrhagic colitis, gastritis, holetsestit, belching, pancreatitis, alopecia, fever, chills, exfoliative dermatitis, abrasions, skin dryness, discomfort.
To reduce the severity of side effects from the digestive tract during the use of Kaletra and Combivir, recommend the use of drugs to eat anything fatty.
Contraindications to the use of Kaletra
Kaletra is contraindicated in under the instruction: intolerance of ritonavir, lopinavir, severe hepatic failure, children up to two years, during lactation. With care prescribe a drug for hemophilia A and B, viral hepatitis C, B, dyslipidemia, pregnancy.
The use of Kaletra and Combivir is the most optimal solution for retroviral therapy during pregnancy.