Izoprinozin

 Izoprinozin

Izoprinozin - complex synthetic immunostimulatory and antiviral drug used to treat diseases caused by gerpevirusami.

Widely used in pediatrics to enhance immunity in chronic and prolonged viral diseases.

Pharmacological action

The active substance izoprinozin has antiviral and immunostimulatory activity. It reduces clinical manifestations of viral diseases and blocks the proliferation of different viruses.

Isoprinosine also helps to speed recovery and improve the body's resistance to various gerpevirusam (Epstein-Barr virus, varicella-zoster), measles virus, mumps and others. In the appointment of other antiviral drugs (acyclovir and zidovudine) enhances the action of interferon.

In the opinion of Isoprinosine generally well tolerated and approved for use in pediatric patients.

Product form

Isoprinosine is produced in the form of white oblong biconvex tablets with amine odor. Each tablet contains 500 mg of the active ingredient inosine pranobex. Other ingredients - wheat starch, mannitol, magnesium stearate, povidone. 10 tablets in a blister, 2, 3, 5 blisters in a carton box.

At the same doses and release Isoprinosine analogs.

Indications izoprinozin

According to the instructions assigned Isoprinosine both weakened, and with a normal immune system when:

  • Infectious mononucleosis caused by the Epstein-Barr virus;
  • Infections caused by the virus Herpes simplex 1-4 types (labial and genital herpes, herpetic keratitis);
  • Corey;
  • Viral bronchitis;
  • Papillomavirus infections, including papilloma vocal cords and larynx fibrous type warts, genital HPV infection in men and women;
  • Equine encephalitis;
  • Cytomegalovirus infection;
  • Herpes zoster;
  • Flu and SARS protracted;
  • Acute and chronic viral hepatitis B and C;
  • Varicella;
  • Chronic infections of the respiratory and urinary systems;
  • Subacute sclerosing panencephalitis;
  • Molluscum contagiosum.

Also Isoprinosine quite effective in immunodeficient states and appointed in the recovery period after serious illness and stress for the prevention of infectious diseases.

Contraindications

Izoprinozin of instruction is contraindicated in:

  • Urolithiasis;
  • Arrhythmias;
  • Chronic renal failure;
  • Gout;
  • Hypersensitivity to the izoprinozin;
  • The drug is not indicated for children under 3 years of age (or birth weight less than 15 kg).

Instructions for use izoprinozin

 Groprinosin - similar izoprinozin

Izoprinozin Inside, after a meal, washed down with a little water.

Dose izoprinozin calculated by instructions is the same for both adults and children - 50 mg per 1 kg of body weight per day. The dose may be divided into 3-4 hours. Individual dose may be doubled for severe forms of infectious diseases, it is necessary to divide it into 4-6 doses. The maximum daily dose for children Isoprinosine is 50 mg per 1 kg of body weight, and adults - 3-4 g per day.

The duration of treatment depends on the nature and course of the disease:

  • In acute diseases in children and adults, the duration is from 5 to 14 days. Treatment should include the disappearance of clinical symptoms, and continued for a further two days;
  • In chronic (recurring) disease treatment prescribed multiple courses of 5-10 days. The break between courses is 8 days;
  • When maintenance therapy can be applied maintenance dose - 0. 5-1 grams per day for a month.

When herpes infection Isoprinosine children and adults is prescribed for 5-10 days to complete disappearance of symptoms. Then, during the months supportive therapy to reduce the number of relapses of 1 tablet twice a day.

Adults with papilomavirusnoy infection drug prescribed 2 tablets 3 times a day. Izoprinozin dose for children is half a tablet per 5 kg of body weight per day for 14-28 days. The same dose is prescribed for recurrent genital warts alone or with surgery. Further, with an interval of a month course is repeated three times.

When cervical dysplasia associated with human papillomavirus, 2 tablets 3 times a day take over 10 days, and then appoint another 2-3 courses with an interval of two weeks.

Side effects

Izoprinozin - quite safe drug, used in world medical practice since 1970.

In the opinion of Isoprinosine well tolerated by adults and children. Occasionally you may experience itching, joint pain, headache, polyuria, dizziness, nausea, weakness, drowsiness or insomnia, worsening gout.

Sometimes reviews Isoprinosine as a side effect causes toxic hepatitis and renal complications in children. Therefore it is recommended to carry out the control of uric acid in the serum and urine after two weeks of use of the drug, as well as a month to start taking hold control of liver and kidney function. Such monitoring should be carried out and the use of combination therapy with drugs that increase the levels of uric acid and impairs the function of the kidneys.

Please note that while the use of immunosuppressive agents may decrease the effectiveness of izoprinozin. Do not take the medication in conjunction with immunosuppressive agents.

Application izoprinozin during pregnancy and lactation is not recommended due to lack of clinical studies.

Most similar in chemical composition and therapeutic effect analogues izoprinozin - Groprinosin and Inosine pranobex. These preparations also contain the active substance and dosage. The difference depends on the trade names of manufacturers of medicines. These analogs izoprinozin may optionally replace drug.

Storage conditions

Izoprinozin related to drug list B. Shelf life - 5 years.





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