Izoket

 Izoket
 Izoket - vasodilator drug used for the relief and prevention of angina attacks.

Pharmacological action

The active substance Izoketa - isosorbide dinitrate.

It possesses vasodilating and vasodilating properties, reducing the need for heart muscle of oxygen and energy, reduces the load on the myocardium.

It helps reduce the pressure in the pulmonary circulation and ventricular wall stress, reduces the diastolic pressure in the ventricles of the heart, improves systolic function, eliminating the spasm of coronary vessels, as well as significantly lower blood pressure.

No effect on heart rate and promotes the expansion of cerebral blood vessels. Dilates blood vessels of the brain, which can cause headaches. It increases the possibility of increasing physical activities in coronary heart disease.

When using spray Izoket by absorption of the active substance across the oral mucosa area of ​​the therapeutic effect occurs quickly and lasts less than an hour.

Product form

Izoket - colorless, transparent solution with the smell of alcohol. The drug is released in the form:

  • Spray Izoket. 1 1 dose contains 25 mg of active substance isosorbide dinitrate, adjuvants - 400 macrogol and ethanol. The dose vials of 15 mL (equivalent to 300 doses);
  • Izoket concentrate for solution. 1 ml solution containing 1 mg of active substance isosorbide dinitrate, adjuvants - sodium chloride, water for injection, a solution of hydrochloric acid, sodium hydroxide solution. In vials of 10 ml. 5 vials in contour packages for 2 packages in cardboard packs.

Indications Izoketa

 Izoket Spray
 Izoket used as a spray at:

  • Stroke, as well as for the prevention of strokes;
  • Acute myocardial infarction (including with acute left ventricular failure);
  • Condition after myocardial infarction.

Izoket by instructions in the form of solution for injection is used for diseases of the cardiovascular system:

  • Unstable angina (predinfarktnom syndrome, threatening myocardial infarction);
  • Coronary vasospasm in surgical interventions for the treatment and prevention;
  • Acute myocardial infarction with left ventricular failure;
  • Acute left ventricular failure;
  • Heart failure of any etiology;
  • Vasospastic angina;
  • Pulmonary edema.

Contraindications

Izoket Spray is contraindicated in:

  • Severe arterial hypotension;
  • Cardiogenic shock;
  • Acute circulatory collapse (circulatory collapse);
  • Form-closure glaucoma;
  • Lack of glucose-6-phosphate dehydrogenase;
  • Hyperthyroidism;
  • The age of 18;
  • Hypersensitivity to the drug (to nitrate compounds).

Do not use spray Izoket simultaneously with phosphodiesterase-5 inhibitors because of the possible increase the hypotensive effect.

According to the instructions Izoket as a solution for infusion is contraindicated in:

  • Cardiogenic shock;
  • Acute vascular insufficiency (vascular collapse, shock);
  • Constrictive pericarditis;
  • Hypertrophic obstructive cardiomyopathy;
  • Severe arterial hypotension;
  • Cardiac tamponade;
  • Toxic pulmonary edema;
  • Hemorrhagic stroke;
  • Traumatic brain injury;
  • Hypersensitivity to the drug (to nitrate compounds).

Instructions for use Izoketa

Izoket spray sprayed in the mouth cavity, whereby it is easy to enter the bloodstream. Depending on the symptoms apply:

  • For relief of angina attack, as well as to emotional or physical stress that can bring on an attack - by 1-3 injections. The required interval between injections - 30 seconds. At the same time it is necessary to hold the breath. This dose can not be increased independently without a doctor's recommendation;
  • In acute myocardial infarction and congestive heart failure the initial dose - 1-3 injections. It is necessary to control both blood pressure and heart rate. Under the supervision of a physician, if there was no improvement for 5 minutes, the injection can be repeated.

According to the instructions Izoket as a solution for infusion is used intravenously. Dose picked individually, depending on the clinical and hemodynamic parameters. Treatment starts with a low dose and gradually increase to the desired.

Recommended dose - 2-7 mg / h, the average dose - 7, 5 mg / h, in some cases - up to 10 mg / h. Typically patients with heart failure, elevated doses are required.

The drug is used in a hospital setting under the constant supervision of the testimony of the cardiovascular system. For intravenous use automatic infusion systems.

The solution Izoketa opened under sterile conditions prior to use. Before application, a solution:

  • For a concentration of 100 micrograms / ml (0 01%) - 50 ml 0, 1% solution of the drug can be prepared with 500 ml of final solution;
  • For a concentration of 200 micrograms / ml (0 02%) - 100 ml of 0, 1% solution of the drug can be prepared with 500 ml of final solution.

To calculate the dose calculated using a special table. Solution for infusion may be stored for 24 hours.

Side effects

When using Izoketa can be observed violations of the cardiovascular system - lowering blood pressure (usually the first application or in cases of increasing doses), which can cause dizziness, weakness, lethargy. Sometimes there is so-called "nitrate" headache that occurs early in treatment and is held in a few days.

Nausea, dry mouth, vomiting, redness, heat sensation are rare.

When using Izoketa can not drink alcohol. You also can not undo the drug abruptly, but should gradually reduce the dose.

The drug is prescribed with caution in hepatic and renal failure.

In case of overdose may develop hyperthermia, collapse, fainting, increased intracranial pressure, palpitations, headache and dizziness, visual disturbances, seizures, skin flushing, nausea, sweating, diarrhea, vomiting, paralysis, coma.

In an application Izoketa with other vasodilators, beta-blockers, antihypertensives, antipsychotics, calcium channel blockers slow, ethanol, tricyclic antidepressants, novokainamidom, quinidine, phosphodiesterase inhibitors may experience increased hypotensive effect.

During pregnancy and breastfeeding Izoket used with caution and strictly according to indications.

Storage conditions

Izoket related to drug list B. term storage solution for injection and spray - 5 years.





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