Goldline

Goldline - is one of the drugs for the treatment of obesity, registered in Russia since 2009. This drug is manufactured by RANBAXY LABORATORIES Ltd. (Bulgaria). The active ingredient in Goldline is sibutramine, as well as in a number of other medicines - Reduxine, Lindakse, Merida. The drug is sold in pharmacies by prescription. Even if you have the opportunity to buy medicine without a prescription (for example, Internet pharmacies) is strictly not recommended to start treatment with this serious drug without consulting a specialist.  Drugs for weight loss Goldline

Composition Goldline tablets and the form of the drug

The drug is available in the form of capsules 15 mg of sibutramine hydrochloride monohydrate. Other ingredients: lactose, microcrystalline cellulose, colloidal silicon dioxide, magnesium stearate. The bundle may be 10 or 30 capsules.

Pharmacological action

Goldline tablets are centrally acting agents. Sibutramine is included in their composition, inhibits the reuptake of neurotransmitters serotonin and norepinephrine in the brain. These substances - so-called "happy hormones". Their higher concentrations reduce appetite, the need for food and promote faster saturation. Sibutramine also increases termoproduktsiyu, which increases calorie consumption by the body.

Pharmacokinetics Goldline

Once inside Goldline is well absorbed from the gastrointestinal tract .  The blood gets at least 77% of the active substance .  Next Goldline biotransformation in the liver, where acquires its active form in the form of metabolites .  The maximum drug concentration in blood is 1, 2 hours, and its active metabolite - within 3-4 hours .  Simultaneous treatment with medicines and food reduces the maximum concentration of 30% and slows its onset time is 3 hours .  Goldline is rapidly distributed to all body tissues .  It is well connected to plasma proteins (94-97%) .  After 4 days of regular use of tablets the plasma concentration peaks and higher than the same value after a single dose of Goldline twice .  Thus, the maximum effect of the drug begins after only a few days of treatment .  The active ingredient tablets Goldline displayed in the kidneys .  After 14-16 hours from the moment of reception of the concentration of the active metabolite in the blood plasma falls twice .  The following drugs are detected in the body for several days after the cessation of the use of tablets .

Indications

Doctors prescribe Goldline slimming. Justified application of the preparation in the presence of overweight or obesity. Body mass index (Quetelet index) should be more than 27 kg / m². Increased body weight at the same time must be associated with alimentary-constitutional reasons, that is, heredity, lifestyle, nutrition. Other causes of obesity (genetic syndromes, endocrinological diseases, pathology of the central nervous system) Goldline not treated.

Contraindications to the use of tablets Goldline

This medicine has a lot of contraindications, so it must be assigned a doctor and only after careful examination .  So Goldline diet should not be taken if the patient has organic causes of obesity (hypothyroidism, prolactinoma), bulimia nervosa, mental illness, alcoholism, drug addiction, stroke, heart disease and blood vessels, arrhythmia, uncontrolled hypertension, pheochromocytoma, thyrotoxicosis, BPH, angle-closure glaucoma, severe kidney or liver disease .  Do not take pills Goldline children under 18 and elderly patients over 65 years old, and pregnant women and nursing mothers .  You can not both drink Goldline and other drugs for weight loss central action, as well as drugs that act on the central nervous system (antidepressants, anticonvulsants), monoamine oxidase inhibitors, tryptophan .  If you have installed an allergy to sibutramine or excipients of the drug, it is not prescribed Goldline .

The dosage regimen of pills Goldline

Goldline appointed interior 1 time per day. The medicine must be taken in the morning, regardless of the power, with a glass of water. The maximum dose of 15 mg per day. Duration of therapy should not be more than 2 years. If after 3 months of treatment effect is not satisfactory, the drug overturned. Using Goldline diet should be only in combination with diet and exercise. Treatment should supervise an experienced physician (an endocrinologist).  Dosage form Goldline - Capsules

Side effects Goldline

During the first month of Goldline most likely to develop side effects. Over time, the severity of these phenomena is weakened. On the part of the central nervous system can insomnia, headaches, dizziness, anxiety. Cardio-vascular system are sometimes observed palpitations, increased blood pressure, redness of the skin. On the part of the gastrointestinal tract may be dry mouth, loss of appetite, constipation, nausea, change in taste. Sometimes there is increased sweating, itching. Infrequently after cessation of treatment develops a reaction to the abolition of Goldline - increased appetite, headache. In isolated cases, fixed and other side effects.

Storage conditions Goldline

The medicine should be stored out of the reach of children. At a temperature of 25 degrees medication pass within two years from the date of production.

Cautions

In women of childbearing age taking Goldline must simultaneously provide a thorough contraception.

Each patient receiving Goldline, at least once every two weeks should be measured blood pressure. For values ​​over 145/90 mmHg Goldline overturned. Also count your heart rate. At rest, it should be up to 90 beats per minute.

Goldline may affect the ability to drive vehicles and mechanisms.

Reviews Goldline

Reviews Goldline physicians (endocrinologists and therapists) generally positive. It noted its high efficiency. Typically, a drug prescribed to patients obese, prone to overeating carbohydrates, bulimia. The drug is used with caution in trying to just young people without severe chronic diseases. Such wariness caused by the fact that in many countries sibutramine banned due to the risk of death in patients of heart attack or stroke, as well as suicide. Such risks have been identified in the course of relatively long controlled studies. In Russia in 2008, a substance included in the approved list of potent drugs.

In a review of Goldline patients have a high efficacy of the drug. Patients like sudden loss of appetite, increased mood, performance, alertness, which they associate with the drug. The negative reviews say about the side effects: hypertension and insomnia.





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