Glutargin - the salt of the amino acid arginine and glutamic acid, are important for the processes of neutralization and ammonia excretion from the body.
Glutargin has gipoammoniemicheskoe action that is expressed in the activation process of neutralization of ammonia, it is bound to nontoxic glutamine and subsequent elimination from the central nervous system and body as a whole. Thus Glutargin reduces general toxic and neurotoxic effects of ammonia.
Antioxidant, membrane and antihypoxic properties Glutargin cause gepaprotektornoe (cleans and restores the liver) effects of the drug.
Glutargin effective for alcoholic intoxication, as able to stimulate the deposit of alcohol in the liver, to prevent inhibition of alcohol dehydrogenase (enzyme main ethanol utilization), accelerates the inactivation and excretion formed by metabolism of ethanol toxic products and reduce the inhibitory effect of alcohol on central nervous system. These properties determine the anti-toxic and sobering effect Glutargin.
The drug has no gonadotoxic (menstrual dysfunction, infertility, weakening of potency), embryotoxic (toxic to the fetus), teratogenic (development of congenital abnormalities in the fetus) and mutagenic, and does not cause allergic reactions and immunotoxic.
Take Glutargin manual recommends that you:
- acute and chronic hepatitis of various etiologies;
- cirrhosis of the liver;
- poisoning hepatotropic poisons, including mushrooms, medicinal and chemical substances;
- leptospirosis (an infectious disease characterized by fever, liver, kidneys, nervous system, general intoxication);
- precoma and coma, accompanied by hyperammonemia;
- hepatic encephalopathy (mental and neuromuscular disorders caused by liver failure);
- Alcohol Poisoning mild to moderate;
- postintoksikatsionnyh disorders that were caused by alcohol.
Instructions for use Glutargin
Glutargin tablet intended for oral administration.
When hepatitis and hyperammonemia is recommended to take 0, 75 grams of the drug three times a day, regardless of meals. This therapy is usually held within 15 days. If necessary, a single dose may be increased to 2 g, and the treatment duration up to 20 days.
When alcohol poisoning Glutargin tablets administered in a single dose of one of the multiplicity of reception - 4 times a day at intervals of 1-2, 5:00. Subsequent 2- 3 days is recommended to take on 0, 5 g of 3 times per day.
After the treatment of severe alcohol poisoning by injecting drug prescribed Glutargin tablet intake that usually designed for a 20-day course. The dosage regimen in this case is as follows: two times daily for 0, 75 g of the drug, or 1 times a day for 1, 5 g
In order to prevent alcohol intoxication is recommended to take 2 grams Glutargin 1-2 hours before drinking alcohol.
Perhaps the use of the drug by intravenous drip after a preliminary dilution of 150-250 ml of isotonic sodium chloride solution. According to the instructions, Glutargin necessary to introduce 5 ml twice daily at a rate of 60 drops per second. Heavy state suggest bringing a daily dose of 15-20 ml. The course of treatment - 5-10 days. If necessary, continue therapy Glutargin pills.
Glutargin, instruction confirms well tolerated, only in rare cases after applying the drug may nausea and a feeling of mild discomfort in the digestive tract. Typically, these adverse effects are their own and do not require discontinuation of therapy.
Absolute contraindications to the use Glutargin not.
Caution is needed in increased excitability, fever, severe violations of the kidney filtration.
Efficacy and safety of Glutargin during pregnancy, lactation, and in children and adolescents have not been investigated.
According to the instructions, Glutargin should be stored at room temperature away from moisture and sunlight.
Useful drug is considered to be within 2 years from the date of production.