Glibenclamide

 Glibenclamide formula
 Glibenclamide - antidiabetic drugs.

Pharmacological action

Glibenclamide acts stimulator cells in the pancreas that produce insulin.

Glibenclamide lowers blood sugar, cholesterol, blood clotting.

Compared with peers glibenclamide preparations of the first generation means is characterized by high activity, good absorption and tolerability.

The duration of glibenclamide - 8-12ch.

Glibenclamide modern counterparts are: Gilemal, Betanaz, Glibamid, Glidanil, Glitizol, Maniglid, Glimidstada Manin, Glyukobene, Euglyukon

Product form

Glibenclamide release tablets.

Indications

The instructions glibenclamide stated that it is administered with insulin dependent diabetes diabetes moderate who uncomplicated microvascular.

Instructions for use of glibenclamide

 Glibenclamide tablets
 The drug is taken orally one or two p / day. The instructions glibenclamide indicates that the average dose ranges from 2 5-15mg per day.

After normalization of the amount of glucose in the blood on maintenance therapy - 0, 005-0, 01gr per day. Sometimes designated 0, 0024-0, 0075gr.

If after 4-6 weeks, the daily dosage of the drug 0, 015-0, 02gr no effect, begin the complex therapy, adding to glibenclamide biguanides. If this combination is ineffective, begin taking insulin.

side effects

The use of glibenclamide by improper diet and dosage can cause a drop in blood sugar.

Perhaps the appearance of allergic rashes, itching, nausea, feeling of heaviness in the stomach, diarrhea. Rarely is a violation of the drug sensitivity and blood, liver function, paresis, photosensitivity, headache, dizziness, fatigue.

Contraindications

According to the instructions in the glibenclamide is contraindicated in patients prekomatosnoe and coma.

Not prescribers with ketoacidosis, pregnancy, lactation, in violation of the functionality of the kidneys, liver, acute infectious diseases, thrombocytopenia, leukopenia, granulocytopenia, when allergy to sulfonamides, diabetes mellitus type 1, extensive burns, trauma, surgery, intestinal obstruction , gastroparesis.

Be wary appoint glibenclamide in alcoholism, adrenal insufficiency, feverish syndrome, diseases of the thyroid gland.

Do not use glibenclamide together with inhibitors of the enzyme monoamine oxidase, coumarin derivatives, butadionom.

Be wary appoint glibenclamide together with anabolics, chloramphenicol, salicylates, beta-blockers, blockers of histamine receptors NC.





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