Furazolidone - it is a drug from the group of nitrofurans, which has antibacterial properties.
a synthetic derivative of 5-nitrofurforola. In the opinion of furazolidone is most effective in the treatment of inflammatory diseases caused by Gram-negative aerobic bacteria. In less sensitive to it aerobic Gram-positive organisms, fungi and protozoa. Anaerobic pathogens sensitive to furazolidone.
Pharmacological action furazolidon depends on the received dose: at low doses, the drug has a bacteriostatic effect, and in their increasing - bactericidal. The mechanism of antimicrobial activity is that the nitro group in the molecule by the enzymes furazolidone microorganisms are reduced to amino groups, which are highly toxic to bacteria. Amino violate the integrity of bacterial cell walls and block many biochemical processes in them. As a result, bacteria lose their ability to further the growth and reproduction.
In the opinion of furazolidone has a small and immunostimulatory effects. It is the ability of preparation to increase the phagocytic activity of white blood cells (leukocytes) and the titer compliment.
Furazolidone increases the sensitivity of the human body to ethanol. Therefore, while taking this drug and alcohol develop nausea and vomiting.
Resistance (resistance) to furazolidone bacteria develops slowly.
After ingestion furazolidone rapidly and almost completely absorbed in the intestine. A therapeutically significant concentrations in blood stored for 5 - 6 hours after a single dose. The drug penetrates into the cerebrospinal fluid, where its concentration is the same as in the blood. In the intestine, also have a high concentration of furazolidone.
It is shown mainly kidneys, partly unchanged, partly in the form of metabolites.
This drug is used to treat inflammatory and infectious diseases of the genitourinary system, the gastrointestinal tract and skin. According to the instructions Furazolidone is used to treat the following diseases:
• Typhoid and paratyphoid fever;
• bacillary dysentery;
• Diarrhea caused by infectious causes, such as food poisoning;
• Trichomonas infection;
• cystitis, urethritis;
• Infected wounds and burns of the skin.
The drug is taken orally. The tablet is advisable not to crush or chew and swallow whole with a glass of water.
According to the instructions Furazolidone to treat food poisoning, dysentery and paratyphoid administered four times a day for 100 - 150 mg for 7 - 10 days.
The indication for furazolidone and is trichomonas infection. When this preparation is prescribed coleitis for three days with 100 mg of 3 - 4 times per day. Besides the vagina once daily administered 5 g of the powder consisting of a mixture furazolidone lactose (milk sugar) in a ratio of 1: 400, and in the rectum, rectal suppositories with furazolidone. When Trichomonas urethritis taking furazolidone, 100 mg four times a day for three days.
In the opinion of furazolidone quite effective in the treatment of giardiasis. For adults it is administered four times a day, 100 mg, and children - a rate of 10 mg per kg of body weight per day. The daily dose is distributed into 3 doses.
It justifies the use of furazolidone in the treatment of wound infections and burns. In these cases, the drug is used topically in the form of wet-drying dressings or irrigation solution furazolidone (1: 25,000).
low-toxic drug, but, nevertheless, can lead to side effects: nausea, vomiting, loss of appetite, pain in the epigastric region. According to the instructions furazolidone rarely causes allergic reactions: angioedema, urticaria, pruritus, rash. To prevent the development of adverse reactions is recommended to wash down each dose furazolidone plenty of fluids, take antihistamines and vitamin B.
With prolonged use of furazolidone, especially in infants may develop methemoglobinemia and hemolytic anemia, pyrexia, cough, dyspnea, and neurotoxic reactions.
Contraindications to furazolidone
• Individual hypersensitivity to the drug;
• End-stage renal disease;
• Age of the child under the age of one month;
• Lactose and glucose-6-fosfotdegidrogenaznaya failure.
Indications furazolidone in pregnant women should be carefully assessed by the treating physicians. During pregnancy and lactation the use of furazolidone is permissible only if the potential benefit of the drug is much more potential risks to the fetus (baby).
Furazolidone should be administered with caution to patients suffering from diseases of the nervous system and the liver. It should not be imposed on persons who work requires high concentration of attention and fast reaction.
Interaction with other drugs
Aminoglycosides, tetracyclines and enhance the antibacterial activity of furazolidone. At simultaneous reception and ristomycin furazolidone, chloramphenicol increases the risk of suppression of hematopoietic function.
The drug should not be used with both amphetamines, ephedrine, MAO inhibitors, because it is associated with a high risk of hypertensive reactions.
The ingestion of large doses of furazolidone patient develops liver toxicity until ostrorogo toxic hepatitis. In the opinion of furazolidone in large doses can lead to the development of haematological and neurotoxic effects.
No specific antidote. Displaying gastric lavage and sorbents into the hut and salt laxatives. Assign B vitamins and antihistamines. If necessary, conduct an infusion therapy to maintain fluid and electrolyte balance.
In severe poisoning hemodialysis.
Form release furazolidon
The drug is available in tablet form with an active substance content 0 05 g (50 mg). The tablets are packed 10 pieces in Valium and Valium-outline package.
Storage conditions furazolidon
Furazolidone should be stored at room temperature in a dry place away from children. The shelf life of three years. After the expiration date the drug can not be used for treatment.