Fortum - cephalosporin antibiotic for 3 generations.
The pharmacological properties of Fortum
Fortum contains the active substance - ceftazidime. The mechanism of action of the drug bactericidal. He is violating cell wall formation of micro-organisms that cause their death. Fortum is resistant to the damaging action of bacterial enzymes - beta-lactamase.
Wide spectrum of action of the drug - it is a devastating effect on gram-negative (Pseudomonas, Haemophilus and Escherichia coli, Klebsiella, Proteus, Enterobacter, tsitrobakter, serratsii, Salmonella, Yersinia, Neisseria) and Gram-positive (staphylococci, streptococci) and anaerobes (peptokokki, Clostridium and etc.).
Feedback from Fortum is effective against the bacteria are not sensitive to other kinds of antibiotics. Not valid for methicillin-resistant staphylococcus it.
The drug is well absorbed from the injection site in the muscle, rapidly delivered to the tissue. Through the intact blood-brain barrier to the brain does not penetrate, but in the case of meningeal inflammation (meningitis) in cerebrospinal fluid are achieved therapeutic concentrations of antibiotic. Fortum easily crosses the placenta and breast milk.
In the body, there is no conversion to Fortum metabolites. Unchanged it is excreted in urine, approximately 90% of administered drug is excreted by kidneys during the day. In renal insufficiency, the elimination rate is reduced. It is also important to remember that due to the specific functioning of the body of newborn half-life of the drug slows down 3 - 4 times.
According to the instructions Fortum produce powder for solution for injection in vials of 0, 25, 0, 5, 1 and 2 years
The antibiotic prescribed for severe infections, which are caused by susceptible to the microorganism. It is included in the treatment regimen of sepsis, infectious lesions of the respiratory tract (including complicating cystic fibrosis), urinary tract, ENT organs, skin and soft tissue, abdominal, biliary tract, gastrointestinal tract, bones and joints. Fortum advantage that it helps with nosocomial infections caused by multidrug-resistant microorganisms with other antibacterial agents.
Fortum does not apply in case of intolerance ceftazidime and other cephalosporin and penicillin antibiotics.
Instructions for use Fortum
According to the instructions of Fortum administered parenterally in a vein or deep into the muscle. Dose rate is calculated and individually by the attending physician, and depends on the severity of the condition, age, condition of the kidneys. Adults administered 1 - 6 g / day in 2 - 3 administration. Standard regimens - 1 g after 8 hours, or 2 g in 12 hours. The maximum permissible daily dose for an adult - 6 g, for seniors it should not exceed 3 years
In cases of neutropenia and concomitant immunodeficiency increase the dose - 2 g every 8 hours 3 times a day, or 3 g in 12 hours 2 times per day.
For neonates and infants under 2 months of antibiotic payment - 25 - 60 mg / kg / day in 2 administration.
Children from the age of 2 months, Fortum calculated from 30 - 100 mg / kg / day in 2 - 3 administration. Under reduced immunity, cystic fibrosis and meningitis dose increased to 150 mg / kg / day.
For the preparation of the antibiotic solution can use 0, 9% sodium chloride, 5% glucose solution. For the / m Fortum is usually diluted 0, 5, or 1% lidocaine.
With simultaneous use of high doses of Fortum with diuretics and aminoglycoside antibiotics need to monitor renal function.
Side effects Fortum
In the opinion of Fortum sometimes causes hypersensitivity reactions (in the form of hives, dermatitis, angioedema), diarrhea, abdominal pain, vomiting, candidiasis of the mucous membranes in the kidney disorders, headache, dizziness, cramps, changes in the biochemical analysis of blood and general .
Unpleasant complications may be associated with parenteral administration Fortum - pain, induration and burning at the injection site.