Folacin

Folacin - a drug that stimulates hematopoiesis and compensate for the lack of folic acid in the body. Available as yellow spigot tablets having a chamfer or at risk at one side.

Pharmacodynamics

 Folacin - a drug that stimulates hematopoiesis and compensate for the lack of folic acid in the body
 Folic acid is a vitamin B. In the body it is converted to tetrahydrofolic acid - coenzyme required for full education normoblasts megaloblasts and maturation, as well as participating in various metabolic processes of nature. With a shortage of folic acid in the body develop megaloblastic type of blood formation. Folic acid participates in the synthesis of amino acids (including glycine, serine, and methionine), pyrimidines, purines and nucleic acids, histidine and choline metabolism, stimulates erythropoiesis. During pregnancy protects the fetus from the damaging and teratogenic factors. It promotes proper maturation and function of the placenta.

Pharmacokinetics

After oral folic acid binds to a specific glycoprotein (intrinsic factor) in the stomach and completely absorbed in the gastrointestinal tract. Under the action of the enzyme dihydrofolate reductase in the presence of ascorbic acid, and metabolized deposited to form a tetrahydrofolic acid in the liver. Almost completely bound to plasma proteins.

Folic acid passes into breast milk and placenta. The maximum concentration in blood is achieved within 30-60 minutes after eating. If the received dose exceeds the needed daily dose excreted via the kidneys like as metabolites or unchanged.

Indications for use of the drug Folacin

According to the instructions, Folacin used for:

  • treatment and prevention of lack of folic acid on the background of defective or unbalanced diet;
  • treatment and prevention of anemia on the background of a lack of folic acid: leukopenia and anemia, caused by ionizing radiation and drugs, hyperchromic anemia, post-resection anemia, megaloblastic anemia, anemia associated with malabsorption syndrome, sprue and diseases of the small intestine, sideroblastic anemia in the elderly;
  • prevention of fetal neural tube defects.

Folacin used for long-term treatment of folic acid antagonists (trimethoprim, sulfamethoxazole combination, methotrexate), anticonvulsants (phenobarbital, primidone, phenytoin).

Also apply Folacin during pregnancy and lactation period for treatment and prevention of anemia.

Contraindications to the use of folacin

According to the instructions, Folacin is contraindicated in:

  • pernicious anemia;
  • hypersensitivity to any component of the formulation;
  • cobalamin deficiency;
  • malignancies.

Side effects

According to reviews, Folacin may cause allergic reactions: skin rash, pruritus, erythema, bronchospasm. Also, according to the rating of folacin, from the gastrointestinal tract may experience nausea, anorexia, bitter taste in the mouth and bloating.

Interaction with other drugs Folacin

The absorption of folic acid decreases, while the use of tetracyclines, polymyxin, neomycin and chloramphenicol.

With simultaneous use Folacin reduces the effects of ethanol, methotrexate, chloramphenicol, primidone, phenytoin, glutetimid and cycloserine, sulfasalazine, contraceptives for internal administration.

Dosage and application Folacin

Folacin used inside.

 Folacin taken during pregnancy for the prevention of neural tube defects in the fetus
 For the prevention of megaloblastic anemia due lack of folic acid in the body, using 2, 5 milligrams folacin a day for four months, for the treatment of - 5 mg per day.

For the treatment and prevention of macrocytic anemia of defective or an unbalanced diet, and inflammatory bowel malabsorption Folacin received 15 milligrams a day.

Folacin taken during pregnancy for the prevention of neural tube defects in the fetus. It should be used for 2, 5 milligrams for four weeks prior to pregnancy and during the first trimester of pregnancy.

Cautions

Patients who are on hemodialysis, should be given a higher dose of folic acid.

Prolonged use folacin, especially in high doses, can decrease blood concentrations of cyanocobalamin (vitamin B12), so if you need to take folic acid for a long time, is also appointed by the use of vitamin B12.





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