Flucostat - an antifungal drug, which is a derivative of triazole.
It is widely used for the treatment of lesions caused by yeast and yeast-like fungi.
Flucostat available as a solution for intravenous administration and capsules.
1 ml of the drug solution contains 2 mg of fluconazole and auxiliary substances (sodium chloride, water for injection).
Fljukostat 1 capsule contains 50 or 150 mg of fluconazole and auxiliaries (corn starch, lactose, silica, sodium sulfate, magnesium stearate).
Pharmacological action fljukostat
The active ingredient according to the instructions fljukostat selectively affects specific pathogens fungal origin - cytochrome P-450, seeking violations of the synthesis of sterols, which are "building blocks" to the cell membrane of the fungus. Lack of sterols increases membrane permeability and ultimately destroy it, resulting in the death of the parasite. The inhibitory effect fljukostat and analogues of the drug is also on the enzymes of the human body, however, the use fljukostat not able to have a significant negative effect.
Fluconazole after intravenous injection well into the body fluids and tissues, the concentration of active substance in the blood plasma is directly proportional to the dose of medicament. Patients suffering from a fungal meningitis etymology fluconazole concentration in CSF is 80% of the content of active substance in plasma.
Excretion of fluconazole is conducted mainly by the kidneys, with about 80% - unchanged.
Admission fljukostat for instructions expedient if fungal disease organism varying severity, including primary or secondary immunodeficiencies. A solution for intravenous administration is used to treat patients suffering from diseases caused by Cryptococcus (skin infections, lung tissue, including meningitis) and fungi of the genus Candida (candidiasis of the mucous membranes, candidemia, generalized candidiasis). Fljukostat solution is an effective preventive measure against patients receiving radiotherapy and cytotoxic therapy, as well as preventing the re-emergence of cryptococcosis in people with acquired immunodeficiency syndrome.
Fljukostat capsules for oral administration may be assigned for the purpose of treatment of diseases caused by fungi of the genus Candida, Cryptococcus and other microorganisms are sensitive to fluconazole. According to reviews, Flucostat capsules are widely used for the treatment of mucosal candidiasis, onychomycosis, cryptococcosis, fungal infection of the skin, tinea versicolor. In addition, instructions can be assigned Flucostat physician as a prophylactic agent during surgery.
Application fljukostat vaginal candidiasis possible on prescription.
Flucostat and analogues of the drug is not prescribed for people who have an intolerance of fluconazole, lactose, as well as patients suffering from malabsorption syndrome glucose-galactose, galactosemia and lactase deficiency.
Admission fljukostat with caution is recommended in case of violation of the liver and kidneys, chronic alcoholism, in the preparation of drugs with severe hepatotoxic.
Therapy drug during pregnancy is not desired, use fljukostat possible only with vital evidence. While receiving the drug should abandon breastfeeding.
Side effects fljukostat
Flucostat, reviews, well tolerated by patients. However, when using the drug may experience side effects following risks:
- On the part of the gastrointestinal
tract and biliary system: nausea, vomiting, abnormal stool, change in taste, abdominal pain and epigastric region, jaundice, flatulence, gepatonekroz, increased levels of bilirubin and liver enzymes;
- From the nervous system: dizziness, cramps, headache;
- Cardio-vascular system: flicker and ventricular flutter, lengthening the interval QT, agranulocytosis, neutropenia, leukopenia, thrombocytopenia;
- Allergic reactions: urticaria, angioedema, anaphylactic shock, Lyell's syndrome, Stevens-Johnson syndrome;
- Others: increased levels of triglycerides and cholesterol in the plasma, lowering potassium baldness.
At the use of excessive doses fljukostat may cause hallucinations, paranoid behavior. Antidote to the drug exists. In case of overdose symptomatic treatment is carried out: gastric lavage, the appointment of enterosorbentnyh drugs. In order to reduce the concentration of the active substance in the blood plasma fljukostat possible to carry out forced diuresis and hemodialysis.
It prohibited the simultaneous use fljukostat and unique drug with astemizole and terfenadine. In combination with the above substances capable of changing the efficiency of fluconazole coumarin anticoagulants.
According to the reviews fljukostat, use of the drug with sulfonylureas increases the risk of hypoglycemia.
Combined use of cisapride fljukostat and provokes the appearance of side effects of the cardiovascular system.
This guide to the fljukostat presented only for informational purposes. Do not take the drug without a doctor's recommendation.