The international name - Valium
Structure and Composition Fliksonaze
Available in the form of a nasal spray metered, in dark glass bottles with a dosing device - 60 and 120 doses.
Fliksonaze a glucocorticosteroid agent for intranasal use.
It decreases the production of proinflammatory mediators, biologically active substances. It has a pronounced anti-inflammatory, anti-allergic and anti-edema effect. It inhibits the proliferation of eosinophils, lymphocytes, macrophages, neutrophils, mast cells. The anti-inflammatory effect is due to the interaction with receptors Fliksonaze glucocorticosteroids.
Application Fliksonaze provides a fast and pronounced anti-inflammatory effect on the nasal mucosa. Antiallergic results seen in 2-4 hours after the first dose. The drug stops the majority of symptoms of allergic reactions in the nose: sneezing, runny nose, itching, nasal congestion, discomfort in the sinuses and feeling the pressure. Fliksonaze also removes the unpleasant symptoms of the eyes.
Relief of symptoms or a significant reduction after a single dose persists for 24 hours. Subject to the dosage of the drug has no systemic action and does not inhibit adrenal system.
Intranasal application 200 micrograms fluticasone propionate, it is impossible to determine the maximum concentration of drug in blood plasma, reading is less than 0.01 mg / ml. The degree of absorption in the nasal mucosa and systemic absorption is minimal because of the low solubility of the drug in water, because much of the drug which eventually swallowed. The blood gets less than one percent of the drug. Linking blood protein - 91%.
Fluticasone propionate shows systemic circulation primarily by metabolism in the liver, with the participation of isoenzyme CYP3A4. Excretion occurs excretion through the intestine intact, and in the form of metabolites.
Fliksonaze prescribed for the treatment and prevention of seasonal and perennial allergic rhinitis, including hay fever.
Hypersensitivity to the drug. Is contraindicated in children younger than 4 years.
Caution should be exercised when using Fliksonaze patients with herpes infections and nasal cavity and sinuses, as well as the recent trauma of the nose or nasal cavity operations.
Fliksonaze applies solely intranasally. The therapeutic effect occurs with regular use.
Adults and children over 12 years prescribed 100 micrograms in each nostril 1 times a day, preferably in the morning. After reduction of symptoms can reduce the dose of 50 micrograms into each nostril. The maximum total dose should not exceed 400 mcg. Elderly patients do not need to adjust dosages.
The therapeutic effect of taking Fliksonaze occurs within 3-4 days of therapy.
Possible to use Fliksonaze children from age 4, a dosage of 50 mg / day in each nostril. The maximum permissible dose for children - 200 micrograms.
Instructions for use Fliksonaze
Before using the drug is recommended to shake. To use the drug must place his thumb from the bottom of the vial, and between the index and middle finger grip the dispenser, then by longitudinal compression of the vial, produce injection.
We recommend washing the dispenser clean warm water every 7 days. For this spout is separated from the vial, and after washing is put in place. Use a sharp object to clean the dispenser Fliksonaze instruction is prohibited.
The order of application
- Clean nose washing or blowing the nose.
- Insert the tip of the dispenser into one nostril while blocking another.
- Tilt your head slightly forward.
- Bring a bottle of medicine in an upright position.
- As you inhale through the nose to produce a single press.
- Exhale through your mouth.
- If a double dose is prescribed, make a re-injection into the same nostril.
- In accordance with the foregoing paragraphs to make injection into the second nostril.
- Clean the tip of the dispenser with a clean cloth.
- Close the tip of the dispenser cap.
Overdose Fliksonaze reviews have been recorded. Symptoms of chronic or acute overdose have not been established.
Intranasal adoption Fliksonaze volunteers for 7 days to 2 mg twice daily, did not reveal any effect on the function of the hypothalamic-pituitary-adrenal system. According to reviews Fliksonaze at a long-term use may lead to temporary suppression of adrenal function.
Drug interaction Fliksonaze
Due to the minimum concentration in blood plasma Fliksonaze clinically significant interaction is almost impossible.
When using both Fliksonaze with analogues such as ritonavir is a potent inhibitor of isozyme CYP3A4, probably significant uplift fluticasone propionate concentration in the blood plasma, which leads to lower cortisol levels and can develop all of the side effects caused by systemic effects of corticosteroids.
Pregnancy and lactation
According to the instructions, Fliksonaze therapy is not recommended for pregnant mothers as well as for lactation. When using Fliksonaze and analogues of the drug for these patients should be proportioned alleged benefit from taking the drug to the mother and the likely risk to the fetus.
Side effects Fliksonaze
As a registered user rating Fliksonaze may cause side effects in the form of dryness in the nose and throat, feeling an unpleasant smell and taste, nasal bleeding, burning sensation. There may be allergic reactions such as skin rash, swelling of face and tongue, can occur rarely bronchospasm and anaphylactic reactions. Sometimes it gives a headache.
Fliksonaze stored at room temperature.