The active substance FLEX: ketoprofen - 50 mg. Used Excipients: hydrated soybean oil,
vegetable oil, soy lecithin, beeswax. Capsules Composition: sorbitol, gelatine, glycerol, titanium dioxide, sodium propyl parahydroxybenzoate, ethyl parahydroxybenzoate Sodium.
FLEX has analgesic, anti-inflammatory, and antipyretic action antiagregatine. The analgesic effect is due to both the peripheral and central mechanisms. FLEX has antibradikininovym action.
Being associated with the drug to plasma proteins is 99%. Therapeutic concentration FLEX plasma is maintained for 6-8 hours. The drug is metabolized in the liver by glyukuronirovaniya. Displayed in the kidneys to 8% through the intestines. The drug is not kumuliruet.Period-life 1, 6-1, 9:00.
FLEX is used to treat acute pain in inflammatory processes of various etiologies:
- psoriatic arthritis, osteoarthritis, ankylosing spondylitis, rheumatoid arthritis, gouty arthritis (acute attack of preferred fast dosage forms);
- tenosynovitis, bursitis;
- myalgia, sciatica, neuralgia, sciatica, dorsalgia;
- post-traumatic pain;
- headache and toothache;
- adnexitis, otitis media;
- strains and bruises;
- pain in cancer.
- acute diseases of the gastrointestinal tract;
- idiosyncrasy ketoprofen, acetylsalicylic acid;
- liver and renal dysfunction;
- severe heart failure;
- blood disorders (thrombocytopenia, leukopenia, hemophilia, blood coagulation disorders);
- pain relief after surgical treatment of cardiovascular system;
- breastfeeding and pregnancy;
- Patients younger than 15 years.
Caution should be exercised in patients:
- with rhinitis, bronchial asthma, nasal polyps, urticaria;
- with cerebrovascular disease, hypertension, cardiovascular diseases;
- anemia, blood diseases;
- suffering from alcoholism;
- with cirrhosis caused by alcohol abuse;
- diabetes, hyperbilirubinemia, dehydration, sepsis;
Dosage flexo and instructions for use
FLEX Capsules taken orally without chewing, with water after a meal. The usual dose for an adult is 1-2 capsule 2-3 times a day.
Side effects FLEX
From the nervous
system: dizziness, headache, insomnia, nervousness, agitation, drowsiness, fatigue, depression, confusion, forgetfulness, peripheral neuropathy, migraine.
From the digestive system: gastropathy caused by non-steroidal anti-inflammatory drugs, dyspepsia (nausea, vomiting, bloating, heartburn, diarrhea, loss of appetite), stomatitis, abdominal pain.
From the senses: conjunctivitis, blurred vision, dry mucous membranes of the eyes, redness, conjunctivitis, eye pain, vertigo, hearing loss.
For the skin: eczema, alopecia, erythema multiforme exudative, photodermatitis.
Since the cardiovascular system: tachycardia, increased blood pressure.
From the urinary system: cystitis, edema syndrome, urethritis, interstitial nephritis, hematuria, nephrotic syndrome.
On the part of the respiratory system: bronchospasm, dyspnea, laryngeal edema, hemoptysis, rhinitis, dyspnea.
From the side of hematopoiesis: rarely - anemia, agranulocytosis, leukopenia, thrombocytopenia, hemolytic anemia.
Allergic reactions: itching, skin rash, angioedema, anaphylaxis, exfoliative dermatitis.
According to reviews FLEX can also cause side effects such as myalgia, increased sweating, muscle twitching, vaginal bleeding, thirst.
In overdose Fleksenom possible manifestation of the following symptoms: nausea, drowsiness, stomach pain, vomiting, bleeding, occurrence of renal dysfunction or liver. It is recommended that symptomatic treatment, including gastric lavage and the adoption of Carbon. There is no antidote.
Interaction with other drugs FLEX
FLEX increases the effect of: antiplatelet agents, anticoagulants, fibrinolytic agents, estrogens, ethanol, as well as increases the side effects mineralokortikosteroidov and corticosteroids. Reduces the effect of antihypertensive drugs.
Simultaneous reception Fleksenas counterparts from the group of non-hormonal anti-inflammatory drugs, as well as ethanol, corticosteroids and corticotropin may cause ulceration, of gastrointestinal bleeding and increase the risk of renal dysfunction.
Reviews of Flexi therapy in combination with oral anticoagulants, antiplatelet agents, thrombolytics, heparin, cefoperazone, cefamandole showed tsefatetanom and the possible development of bleeding.
Combination with sodium valproate can cause platelet aggregation disorders.
Gematotoksichnosti FLEX enhanced mielotoksicskie means.
Patients combining flexo with warfarin, lithium salts or anti kumarinovyh should be under a doctor's supervision.
It should be particularly careful when assigning unique FLEX patients with peptic ulcer disease, liver and kidney failure. According to the instructions Flexi-smoking combined with alcohol.
Persons doing work that requires concentration, including the management of vehicles should take extra care during the decision-FLEX.
Storage conditions FLEX
FLEX is stored at room temperature not exceeding 25 ° C, out of reach of children.