Fenkarol - Protivogistaminny effective drug.
Preparations Fenkarol-Olaine, hifenadina - complete analogs Phencarolum.
Release form of the drug and Fenkarol
Fenkarol available in the following dosage forms:
- in the form of round biconvex tablets of 10 mg and 25 mg;
One tablet contains the medicament 10 (25) mg hifenadina hydrochloride. Other components: potato starch, sucrose, calcium stearate.
- as a colorless coarse powder.
One sachet contains 10 mg of powder hifenadina hydrochloride. Additional ingredients: mannitol, aspartame, citric acid, flavor dyurarom orange, peach flavor dyurarom.
Reviews Phencarolum confirm that this drug has antiexudative, antipruritic, antiinflammatory and anti-allergic effect. Hifenadina blocking H1 histamine receptors, reduces the effects of histamine on vascular permeability. In addition, significantly reduces hifenadina hypotensive action and reduces its histamine spasmogenic effect on intestinal smooth muscles and bronchi.
The drug has a number of advantages over other antihistamine medications: This medication has not adrenolytic and anticholinergic effect. That is why Fenkarol can use in the treatment of patients who can not tolerate anticholinergic antihistamine drugs. This drug is virtually lethargy and drowsiness (like diphenhydramine or promethazine), small lipophilic, low toxicity and virtually does not penetrate the blood-brain barrier. The drug not only blocks N1- receptors, but also reduces the level of histamine, increasing the activity of diamine oxidase - an enzyme that breaks down about 30% of the endogenous histamine.
There are reviews of Phencarolum as drug significantly reduces the appearance of arrhythmias.
Half an hour after receiving 45% of the drug from the gastrointestinal tract into the blood plasma penetrates and starts its action in target tissues. One hour after receiving the maximum concentration of drug in blood plasma. The process of disintegration Phencarolum occurs in the liver. Drug metabolites are excreted in the bile, urine, as well as the lungs and intestines for 48 hours.
Fenkarol: indications for use
According to the instructions Fenkarol Phencarolum and analogues are used in the following allergic diseases:
- when dermatoses (eczema, psoriasis, atopic dermatitis, skin itch);
- in acute and chronic urticaria;
- when pollinozah;
- when angioedema angioedema;
- under various forms of drug and food allergies;
- with hay fever;
- with allergic rhinitis and / or conjunctivitis.
The following contraindications Phencarolum:
- Children under three years of age;
- Hypersensitivity to the drug;
- isomaltase deficit / sucrase, glucose / galactose malabsorption, fructose intolerance, as medicament comprises sucrose.
The caution is recommended to use the drug for diseases of the gastrointestinal tract, cardiovascular system, kidneys and liver.
Dosing instructions for Phencarolum
According to the testimony Fenkarol and analogues Phencarolum take orally after meals.
Adults indications Fenkarol recommended to take from 25 to 50 mg three or four times a day. The maximum dose per day, not to exceed 200 mg. The duration of treatment from ten to twenty days. If necessary treatment should be repeated.
Children aged two to three years is recommended to assign to 5 mg of the drug two or three times a day; from three to seven - po10 mg twice a day. Children aged seven to 12 years are usually given 10-15 mg of the drug two or three times a day for children older than twelve years - 25 mg two or three times a day. The duration of treatment - 10-15 days.
Pediatricians most active drug administered as a powder. Phencarolum bag should be diluted in half a glass of warm drinking water and give your child a drink after a meal.
According to the instructions Fenkarol children aged two to three years it is recommended to appoint 10 mg (1 sachet of powder) once a day; from three to seven - po10 mg twice a day. Children aged seven to 12 years are usually given 10 mg of the medication two or three times a day for children older than twelve years - 20 mg (2 bags) two or three times a day.
Side effects Phencarolum
The drug is in most cases well tolerated. In rare cases, judging by the reviews of Phencarolum, the drug can cause drowsiness, nausea, headache, vomiting, abdominal pain. However, most adverse symptoms disappear with the abolition of the drug or when changing dose.
The drug speeds up the absorption of drugs with poorly absorbing properties (eg, coumarin). This medication does not increase the inhibitory effect of sleeping pills and alcohol on the central nervous system.