Pharmacological action Femoston
Femoston is a combined medication used for hormone replacement therapy. Active substances - estradiol and dydrogesterone. As auxiliary agents used: colloidal silicon dioxide, hypromellose, magnesium stearate, corn starch.
Estradiol in their biological and chemical properties identical to natural human sexual hormones. With the help of estradiol in a woman's body filled estrogen deficiency that occurs due to menopause, while providing therapy psycho-emotional and vegetative symptoms of menopause: dizziness, "tide", sweating, insomnia, involution of the skin, increased nervous irritability. Estradiol helps to maintain the tone and elasticity of urogenital tract. Estradiol is also a preventive measure against osteoporosis and fractures, it helps to preserve bone.
Dydrogesterone - progestogen preparation providing phase advance mucous secretion in the inner layer of the uterus, thus reducing the risk of development of hyperplasia and carcinogenesis. Dydrogesterone has no androgenic, estrogenic, glucocorticoid or anabolic activity.
Combining in Femoston estradiol and dydrogesterone provides low-dose regimen of hormone replacement therapy.
According to information received from research reviews, Femoston helps to prevent bone loss in post-menopausal caused by estrogen deficiency.
Estradiol after oral administration of readily absorbed. The drug is metabolized in the liver to form estrone and estrone sulfate. Report mostly in the urine.
Dydrogesterone is readily absorbed in the gastrointestinal tract. Completely metabolized. The main metabolite of dydrogesterone - 20 digidrodidrogesteron. Complete elimination of the drug occurs after 72 hours.
Instructions for use and dosage Femoston
Femoston take one tablet once a day, regardless of the meal.
Femoston 1/10 - in the first part of the 28-day cycle consisting of 14 days, received white pills containing 1 mg of estradiol. In the second half of the cycle takes pills gray containing 10 mg dydrogesterone and 1 mg of estradiol.
Femoston 2/10 - in the first part of the 28-day cycle consisting of 14 days, taking pills pink containing 2 mg of estradiol. In the second half cycle accepted yellow pills containing 10 mg dydrogesterone and 2 mg of estradiol.
Patients whose menstrual cycles have not stopped, application Femoston recommended to start on the first day of the cycle. Patients who have since the last menstrual period was more than one year, taking Femoston can start at any time.
Like its counterparts, Femoston used as hormone replacement therapy disorders caused by natural menopause, or menopause that occurred as a result of surgery. As well as the prevention of postmenstrual osteoporosis.
- suspected or diagnosed breast oncology;
- diagnosed or suspected estrogen-dependent malignant tumors;
- the assumed or established pregnancy;
- vaginal bleeding;
- deep vein thrombosis;
- liver disease;
- Femoston intolerance of components.
Care should be taken to those receiving hormone replacement therapy, under the following conditions: hypertension, endometriosis, uterine leiomyoma, thrombosis and the risk of their development, diabetes, benign liver tumors, cholelithiasis, headache, systemic lupus blood, kidney failure, epilepsy, otosclerosis .
If signs of worsening liver function migrenipodobnyh attack marked rise in blood pressure, pregnancy Femoston intake should be stopped. In case there is thrombosis during treatment Femoston, instruction recommends the abolition of the drug.
According to studies, at long reception of analogue Femoston among hormone replacement therapy drugs for over 10 years, there has been a slight increase in the diagnosis of breast cancer.
Like its analogs Femoston is not contraceptive, if necessary, it is recommended to combine it with the reception nonhormonal contraceptives.
These overdose Femoston reviews show that among the possible symptoms may include: nausea, vomiting, dizziness, drowsiness. For treatment of overdose Femoston instruction symptomatic therapy is recommended.
When concomitantly with drugs Inductors of microsomal liver enzymes, as rifampicin, phenytoin, rifabutin, carbamazepine and barbiturates Femoston action can be weakened.
Natural herbal preparations, which is composed of St. John's wort, may have a stimulating effect on the exchange of estrogen.
Pregnancy and lactation
Instruction Femoston not recommended for use during pregnancy and lactation.
Side effects Femoston
From the digestive system are possible: flatulence, abdominal pain, nausea, rarely - vomiting.
On the part of the reproductive system are possible: breakthrough bleeding, breast tenderness, pain in the pelvic area; rarely - dysmenorrhea, cervical erosion, changes in secretion predmenstrualnopodobny syndrome.
On the part of the central nervous system: headaches, dizziness, depression, nervousness.
Since the cardiovascular system: rarely - venous thromboembolism, rarely - myocardial infarction.
Possible manifestations of dermatological and allergic reactions: rash, pruritus, urticaria.
According to reviews, Femoston can produce side effects in the form of vaginal candidiasis, weight changes, breast carcinoma, peripheral edema, changes in the curvature of the cornea.
Conditions and terms
Femoston should be stored out of reach of children, at a temperature not exceeding 30 ° C. Shelf life - 3 years.