Femara - is a drug belonging to the group of antagonists of hormones and hormonal anticancer agents. It is used
for the treatment of breast cancers.
The pharmacological action of Femara
Femara has a strong antiestrogenic action by blocking estrogen synthesis, both in tumor tissue and in peripheral tissues. Daily intake of the drug helps to reduce concentrations of estrone sulfate, estrone and estradiol in the blood of 75 patients - 95% of the initial level.
The instructions to Femara noted that taking the drug at therapeutic doses does not lead to a violation of the synthesis of adrenal steroid hormones. Therefore, this drug does not require supplemental assignment mineralocorticoids and glucocorticoids.
Femara does not change the content in the plasma concentrations of follicle stimulating hormone and luteinizing hormone, causes thyroid dysfunction, as well as to increase the risk of stroke, myocardial infarction, and osteoporosis.
In the opinion of Femara applied for the adjuvant (supporting) therapy early stages of breast cancer significantly reduces the risk of further disease progression and increases the five-year survival rate of patients with no signs of disease. Femara reduces by 40% the mortality rate among patients who have a pathological process is trapped lymph nodes.
Femara is rapidly absorbed from the gastrointestinal tract. Food intake does not affect the bioavailability. Maximum blood levels achieved after 1 - 2 hours after taking the tablets.
Write mainly as metabolites kidneys. Only a small portion of the drug is excreted through the intestines.
The indications for Femara
The drug is used for the adjuvant treatment of early stage breast cancers in women are postmenopausal (natural or artificially induced). Femara also can be used for first-line therapy in postmenopausal women suffering from common hormone dependent breast cancer.
There are numerous analogues Femara, which have exactly the same indications.
Femara: instructions for use
The drug is recommended to take 1 tablet (2, 5 mg) once a day for a very long time. Extended adjuvant treatment can last up to five years.
If there are signs of progression, treatment should be stopped immediately.
Femara tablets can be taken at any time of day and regardless of the meal.
- Pregnancy and lactation;
- Childhood and adolescence;
- Endocrine status of women in reproductive period.
Pregnancy and lactation
Femara is strictly
contraindicated during pregnancy and lactation. Therefore, when using this tool in women are perimenopausal or early postmenopausal period, they should be advised to reliable methods of contraception.
Side effects Femara
In the opinion of Femara may lead to adverse reactions from the various organs and systems:
- Digestive tract - dyspepsia, nausea, vomiting, diarrhea or constipation, stomatitis, elevated transaminase;
- Nervous system - dizziness, headache, nervousness, irritability, depression, transient ischemic attacks;
- Hematopoietic system - the development of leukopenia;
- Cardiovascular system - tachycardia, increased blood pressure, thrombophlebitis;
- Dermatological reactions - skin rash, itching, sweating, alopecia, angioedema;
- Musculoskeletal - myalgia, arthralgia, osteoporosis.
In the opinion of Femara very often leads to the tides (paroxysmal hot flashes), fatigue, weight gain.
Femara should be administered with caution to patients suffering from severe hepatic impairment. Some side effects of the drug (dizziness, weakness, etc.) can affect the performance of work requiring quick response and high concentration.
In case of accidental or deliberate taking large doses of the drug Femara should immediately seek medical help. Specific antidotes are not known, therefore, for the treatment of poisoning is supportive and symptomatic therapy. The instructions to Femara noted that accelerate the withdrawal of the drug from the body can be sick with hemodialysis.
The composition and the form of packaging Femara
Femara is available in tablets having a lenticular shape and film-coated yellow. On one side of the tablet printed «CG», and on the other - «FV».
Each tablet contains 2, 5 mg of active substance. As auxiliary substances are used: titanium dioxide, iron oxide yellow dye, macrogol 8000, talc, Hypromellose, magnesium stearate, colloidal silicon dioxide, sodium carboxymethylstarch, corn starch, microcrystalline cellulose, lactose monohydrate.
The tablets are packed into blisters of 10 pieces. One carton box - 3 blisters.
Analogs of Femara
Currently marketed drugs in pharmacies, similar in its effect to Femara. These include: Etruzil, Ekstraza, yelling, Neksazol, Letrotera, Letrosan, Letrozole-Teva, Letroza, Letrodeks. Despite the fact that all analogues of Femara in fact have the same pharmacological action is better to take just the drug that is assigned to you by your doctor. In his absence in the pharmacy network, consult with a specialist on a possible replacement.
Conditions and terms
Femara belongs to the B list and released from pharmacies only by prescription. The drug should be stored in a cool dry place, away from children. Shelf life - for five years. After the expiration date the drug use is prohibited.