FARESTON - a non-steroidal anti-tumor anti-estrogenic drug.
Toremifene - analogue
Structure and Composition
FARESTON produced in the form of flat circular tablets (20 or 60 mg). One tablet contains the medicament 20 (60) mg of toremifene citrate. Additional ingredients: lactose, microcrystalline cellulose, sodium starch, corn starch, povidone, magnesium stearate, colloidal anhydrous silica.
Pharmacological action FARESTON
FARESTON has anti-estrogenic and anti-tumor effect. The main active ingredient of the drug blocks the synthesis of estrogen, has a complex effect on the regulation of oncogenic, thereby inhibiting proliferation of tumor cells and causing their death. Reviews FARESTON confirm that through the use of the drug in the treatment fails to eliminate the painful breast engorgement, to eliminate or significantly reduce existing fibrosis and / or cystic formation, as well as to prevent the formation of new pathologies. Before the drug level of progesterone in blood plasma increases, and the prolactin level is gradually reduced, which has a beneficial effect in the therapy.
Some reviews of FARESTON confirms the possibility of efficacy in the treatment of locally advanced and metastatic kidney cancer.
According to the instructions FARESTON used in the treatment of the following diseases:
- hormone-dependent metastatic breast cancer (postmenopausal);
- dyshormonal hyperplasia of the breast.
Contraindications FARESTON according to the instructions as follows:
- endometrial hyperplasia;
- pregnancy and lactation;
- hypersensitivity to the drug;
- severe liver failure.
According to the instructions FARESTON used with caution in metastases in bone, thrombocytopenia, leukopenia and hypercalcemia.
FARESTON - Instructions for use
Every day is recommended to take 60 mg as the standard dose for first-line hormonal treatment. When the drug is administered for the second line treatment of hormone daily dose of medication may be increased to 240 mg. In renal insufficiency, the recommended dose of no need of correction.
Side effects FARESTON
Judging by the reviews of FARESTON, in most cases the drug is well tolerated, but in some cases may cause the following side effects: vaginal discharge or bleeding, dizziness, itching in the genital area, fatigue, depression, hot flashes, sweating, nausea, insomnia.
Less commonly observed
The following side effects: dizziness, headache, blurred vision (cataracts, clouding of the cornea), hearing loss, venous thrombosis, changes in liver enzyme levels, pulmonary embolism. In very rare cases jaundice.
If overdose (receiving more than 680 mg a day) was observed vomiting, fainting, headache, nausea.
Before therapy, all patients must undergo a gynecological examination. The first thing to be examined by the mucous membrane of the endometrium, as the risk of hyperplasia, polyposis and endometrial cancer increases due to estrogen stimulating effect FARESTON.
Patients with cardiovascular disease, as well as bone metastases require more careful observation.
According to the instructions FARESTON does not apply with the following drugs:
- with neuroleptics (phenothiazines, pimozide, sertindole, haloperidol, sulpiride);
- some antibacterial agents (moxifloxacin, erythromycin, pentamidine, antimalarials particularly halofantrine)
- some antihistamines (terfenadine, astemizole, mizolastine);
- with antiarrhythmic drugs class III (amiodarone, sotalol, dofetilide, ibutilide);
- with antiarrhythmic drugs class IA (kvinidinom, gidrokvinidinom, disopyramide);
- with other drugs (cisapride, vincamine, bepridilom, difemanilom).
Concomitant use of thiazide diuretics FARESTON and contributes to the development of hypercalcemia. Simultaneous reception and FARESTON varfarinopodobnyh anticoagulants may increase the duration of bleeding.
Storage conditions FARESTON
The drug should be stored at a temperature between 15 and 25 ° C.