Exoderil - antifungal
medicament for topical use. Active component - naftifine, synthetic antimycotic allylamine substance. Exoderil has fungicidal, fungistatic, bactericidal action. The mechanism of action is to inhibit the biosynthesis of ergosterol in fungal cell by acting on squalene epoxidase. The drug has no effect on cytochrome P450. Exoderil deficiency causes accumulation of squalene and ergosterol in the fungal cell, resulting in the death of the microorganism. Exoderil active against dermatophytes (Trichophyton, Epidermophyton, Microsporum), fungi of the genus Candida, Sporotrix schenckii, molds. Furthermore, the drug is effective for some gram-negative microorganisms, Malassezia furfur. When applied topically Exoderil well penetrates into all layers of the skin, thus creating a therapeutic concentration.
About 6% of the active substance reaches the systemic circulation. The drug is partially metabolized, excreted in the bile and urine. The half-life - 2-3 days.
According to the instructions Ekzoderilu, the drug used for fungal skin diseases, which are caused by susceptible microorganisms naftifine:
- athlete's skin folds, feet (caused by Epidermophyton floccosum including);
- trichophytosis (caused by Trichophyton rubrum, Trichophyton mentagrophytes);
- fungal scalp pathology (microsporia);
- skin lesions, Candida etiology;
- fungal infections, complicated by secondary bacterial infection;
- fungal infection of the external auditory canal.
According to the instructions Ekzoderilu, the drug is contraindicated in case of hypersensitivity to naftifine.
It is forbidden to use Exoderil on the damaged areas of the skin (the wound surface, burns).
Exoderil in the form of a cream, solution used only topically. Apply the drug to clean, dry skin. In the treatment of drug-affected areas of the skin it is recommended to capture and some surrounding healthy tissue (about 1 cm).
In onihomikozah should remove possible number of affected tissues of the nail before applying the medication. Apply Exoderil one - two times a day. Cream and the solution applied to a thin layer to the affected area and rubbed lightly. The duration of therapy depends on the type of disease and individual patient characteristics (in particular, the growth rate of the nail), sometimes up to 6 months or more. The duration of treatment is determined by your doctor.
When ringworm Ekzoderilom average duration of therapy is 2-4 weeks, in severe forms - up to 8 weeks.
When skin lesions
Candida etiology treatment lasts about 4 weeks.
After achieving clinical cure it is recommended to use the drug for 2 more weeks to prevent recurrence of the disease.
When mycosis external auditory canal Exoderil small amount of solution applied to cotton turundas then put it in the ear for 5-7 minutes twice a day. Duration of treatment - at least two weeks.
Not recommended for use under a bandage Exoderil.
The drug is usually quite well tolerated, as evidenced by reviews Ekzoderile from patients. In a few cases recorded appearance of dryness, redness at the site of the drug, a burning sensation. These phenomena are rapidly, it does not require removal of the drug.
Application Exoderil during pregnancy
When applied topically Exoderil has no embryotoxic and teratogenic effects. Use of the drug during pregnancy, lactation is possible on the strict condition and only for its intended purpose and under the supervision of a physician.
Interaction with other drugs Exoderil
In the absence of systemic effects Exoderil and analogues unlikely their interaction with other drugs.
At this time there is no information about overdose Exoderil.
Ekzoderile reviews from patients and dermatologists say the high clinical efficacy of the drug. Exoderil is well established in the treatment of onychomycosis, ringworm, candidiasis lesions. The drug is relatively well tolerated, is relatively safe.
Currently registered such analogs Exoderil: naftifine, Fetimin.
Before using this drug to study in detail the instructions in the Ekzoderilu. Apply the drug should be prescribed by a doctor only.