Eufillin - bronchodilator
Eufillin belongs to the xanthine. It contains the main active ingredient - theophylline. The drug has a widening effect on the bronchial tubes by relaxing the smooth muscles and their eliminating spasms. In addition, it improves the performance of ciliary epithelium of the respiratory tract, improves the reduction diaphragmatic, intercostal, and other respiratory muscles. Eufillin stimulates the respiratory center in the medulla oblongata, improves pulmonary ventilation, oxygen saturation and reduces the concentration of carbon dioxide in it, ie normalize respiratory function.
The mechanism of action is inhibition of eufillin enzyme phosphodiesterase, thus accumulates in the tissues of cAMP decreases flow of calcium ions into the cells responsible for muscle contraction, and it relaxes the muscles of the bronchi.
Eufillin for instructions stimulates heart activity, increasing frequency and force of myocardial contraction. He is able to lower the tone of blood vessels, mainly skin, kidney, and brain. Providing a relaxing effect on the venous wall in the pulmonary circulation, the drug lowers the pressure in it.
Application aminophylline improves blood circulation kidneys, thereby increasing the formation and excretion of urine.
The drug slows down platelet aggregation and makes red blood cells more resistant to damage, that is, it improves the rheological properties of blood.
We know about the tocolytic effect of aminophylline on the uterus, it also increases the acidity of gastric juice.
The tool is well absorbed from the digestive tract, bioavailability it reaches 100%. At simultaneous reception with food slows the absorption of a few. It passes into breast milk and placenta. Aminophylline metabolism occurs in the liver, removing it from the body is via the urine.
Aminophylline on instructions available in tablets of 150 mg in ampoules in 2, 4% and 24% solution.
The drug is used to relieve asthma attacks, heart failure, angina, pulmonary edema and other conditions associated with stagnant. In the opinion of Eufillin effectively reduces pressure in hypertensive crises. It is used in the treatment of stroke and other ischemic conditions of the brain in neonatal apnea.
Application eufillin contraindicated in his intolerance, in the acute phase of myocardial infarction, in the collapse, paroxysmal tachycardia, arrhythmia, epilepsy, hyperthyroidism, peptic ulcer disease, disorders of the liver and kidneys, with prostate cancer, diarrhea. Not recommended use of the drug in tablets under the age of 6 years.
Instructions for use eufillin
In the form of a solution
the drug is administered intravenously and intramuscularly, parenteral administration justified the treatment of urgent and emergency conditions. In this case the dose is calculated individually depending on the severity of the condition on the patient's weight.
For adults, a dose in an emergency by aminophylline instructions selected at 6 mg / kg, it was diluted with 20 ml of physiological saline solution, and injected by slow intravenous injection for at least 5 minutes.
Status asthmaticus requires infusion administration of the drug in an amount of 720 - 750 mg. Parenterally administered Eufillin not recommend a maximum of 14 days.
To relieve symptoms of chronic obstructive pulmonary disease in the acute phase begin with a dose of 5 - 6 mg / kg of the drug. If you need to raise it should be very carefully controlled the content of his blood.
In tablets Eufillin take on 0, 15 g of 1 to 3 times a day, after meals. The course of treatment can last from several days to several months.
When neonatal apnea, when breathing stops last from 15 seconds while slowing heart rate, the initial dose of the agent for newborns is 5 mg / kg / day in 2 divided doses. Enter product of a nasogastric tube. With the stabilization of the switch to a maintenance dose of 2 mg / kg / day in 2 divided doses. Duration of treatment may range from several weeks to several months.
Depending on the severity and indications of aminophylline in children the daily dose ranging from 6 to 15 mg / kg.
For elderly patients should be cautious in treating drug. In the opinion of Eufillin enhances side effects of glucocorticoids and mineralocorticoid agonists. Do not use this tool in conjunction with other xanthine derivatives.
Side effects of aminophylline
In the opinion of Eufillin can cause undesirable effects such as insomnia, dizziness, agitation, headache, tremor, palpitations, arrhythmias, heart pain, lower blood pressure, abdominal pain, nausea, heartburn, vomiting, diarrhea, allergic reactions, increased perspiration, reduction in blood glucose, the changes in urinalysis.