Ethinylestradiol

Ethinyl estradiol - hormonal  The formula Ethinyl
   agent used in the treatment of diseases caused by lack of estrogen.

Pharmacological action

The active ingredient Ethinyl estradiol causes endometrial proliferation, and contributes to a more intensive development of the fallopian tubes, uterus and female secondary sex characteristics in cases of underdevelopment. It allows you to soften or eliminate completely the female body the consequences that arise due to lack of gonadal function.

In addition, the active substance Ethinyl:

  • It has a weakly expressed anabolic effect;
  • It causes sodium retention and water (when used in high doses);
  • Has hypocholesterolemic action (helps reduce cholesterol levels in the blood);
  • Increases calcium absorption and promotes the formation of bone calcium stores.

Product form

Ethinylestradiol release medicament in the form of tablets of 10 and 50 micrograms.

By analogues Ethinyl mechanism of action include: Divigel, CLIMAR, Ovestin, Sinestrol, Elvagin, Estrozhel, Estrovagin, Ovipol Clio Estrokad.

As an active ingredient Ethinyl estradiol is a part of the combined drugs as Marvelon, Mersilon, Lindinet 20, Chloe, Rigevidon Belluno 35 mikrofollin, Novinet, Yasmin, three-regolith, Rigevidon, Lindinet 30 Triziston, Genette, Trikvilar, Logest, Jeannine , Jess, Femoden, Midian.

Indications Ethinyl

According to the instructions Ethinyl estradiol is prescribed for the treatment of:

  • Hypovarianism (dysmenorrhea, primary and secondary amenorrhea, oligomenorrhea, gipomenoreya);
  • The androgen-dependent prostate cancer;
  • Infertility;
  • Metrorrhagia (including therapy in menopause);
  • Hypogonadism;
  • Vaginitis (both girls and postmenopausal);
  • Some forms of breast cancer;
  • The secondary estrogen deficiency;
  • Sexual infantilism;
  • Acne;
  • Post-castration and menopausal disorders.

Furthermore, Ethinylestradiol used for suppression of lactation postpartum and in combined preparations - for contraception.

Contraindications Ethinyl

Ethinyl estradiol is contraindicated to apply at:

  • Breast cancer and other estrogen-dependent tumors;
  • Herpes pregnancy in history;
  • Vaginal bleeding of unknown origin;
  • Pregnancy and lactation;
  • Endometriosis;
  • Severe cardiovascular disease;
  • Thrombosis and embolism;
  • Sickle-cell anemia;
  • Hepatic Insufficiency.

Observe  The analogue Ethinyl
   caution when taking on Ethinyl background:

  • Epilepsy;
  • Bronchial asthma;
  • Diseases of the heart and kidneys;
  • Migraine;
  • Hypercalcemia;
  • Otosclerosis;
  • Hypertension;
  • Systemic lupus erythematosus;
  • Multiple Sclerosis.

Dosing Ethinyl

The dosage of ethinyl estradiol and the duration of its application depends on the indications.

When oligomenorrhea and amenorrhea usually ethinylestradiol administered in a daily dosage of 0, 02-0, 1 mg for twenty days.

Dysmenorrhea shown the intake of one to three tablets (10 mg) per day for twenty days (from day 4-5 of the menstrual cycle). Treatment effective for 2-3 months.

When menopausal disorders female under the age of 45 years take on 0, 05 mg per day.

Ethinyl estradiol treatment of cancer (such as breast cancer in women aged 60 and prostate) are usually long. Single dose ranges from 0 05 to 0 1 mg three times a day. As a rule, the treatment is combined with radiation therapy.

When treating acne administered from 3 to 6 tablets (10 mg) per day during puberty - from one to three tablets.

When applying for Ethinyl estradiol suppression of lactation take on 0, 02 mg three times a day during the first three days after birth and then gradually reduce the dosage. The total duration of the reception Ethinyl estradiol is typically 9 days.

Drug Interactions

When ethinyl estradiol therapy should be considered that estrogens that are part of the drug, reduce the effects of anticoagulants and hypoglycemic and antihypertensive agents.

Side effects Ethinyl

In the opinion of ethinylestradiol can cause disorders of various body systems, namely:

  • Hyperpigmentation of the skin (dermatological reactions);
  • Changes in libido, pain and breast enlargement, decreased glucose tolerance (endocrine system);
  • Disorders of the gastrointestinal tract, nausea, vomiting, abnormal liver function, jaundice (digestive system);
  • An increased tendency to thrombosis (blood system);
  • Headache, depression, dizziness, migraine (nervous system);
  • Weight gain and edema (metabolism).

Storage conditions

Ethinyl estradiol belongs to a number of hormonal drugs List B with a recommended shelf life of 24 months.





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