Etaperazin - antipsychotic, affects mainly the central nervous system.
Dosage form etaperazin - coated tablets. 1 tablet medicament comprises 4, 6, and 10 mg of perphenazine.
Pharmacological action etaperazin
The drug is a neuroleptic - antipsychotic, has anti-allergic, sedative, muscle relaxant, antiemetic, weak anticholinergic, hypotensive, antiemetic and hypothermic action. Efficiency etaperazin due to blockade of D2-receptor Mesocortical and mesolimbic system.
According to the instructions Etaperazin has an inhibitory (sedative) effects on the nervous system by blocking adrenergic receptors reticular formation of the brain without causing a soporific effect (in normal dosages).
Antiemetic effect of the drug due to blockade of dopamine receptors trigger zone of the vomiting center. Hypothermic effect etaperazin achieved due to the blockade of D2-receptors of the hypothalamus.
The feedback to the etaperazin contains information about a wide range of action of the drug compared with chlorpromazine: Etaperazin action active this means, however, inferior to him in Adrainoliticaskie and hypothermic effect, as well as its ability to increase the effects of drugs and medicines.
Pronounced antipsychotic effect of the drug develops within 3-7 days after the start of the reception and reaches its maximum after 2-6 months of continuous use.
According to the instructions Etaperazin used to treat mental illness (such as exogenous organic and senile psychoses with hallucinatory phenomena, schizophrenia, personality disorder, itching, hiccups). Judging by the reviews to etaperazin, a drug successfully used in uncontrollable vomiting in pregnant women.
In some cases, the drug can cause extrapyramidal disorders (tremor, incoordination, volume reduction), drowsiness, blurred vision, akathisia, vegetative disorders, lethargy, depression, confusion of consciousness, decreased motivational activities. Cardio-vascular system can lower blood pressure, cardiac arrhythmia, tachycardia, marked ECG changes. On the part of the digestive tract of reviews to etaperazin marked side effects such as atonic bladder and intestines, stomach pain, loss of appetite, nausea, vomiting.
By allergic reactions of the drug include contact dermatitis, skin rashes, photosensitivity, angioedema.
Side effects etaperazin associated with anticholinergic effect of the drug: accommodation disturbances, dry mouth, difficulty urinating, constipation.
prohibited endocarditis - a disease associated with inflammation of internal cavities of the heart, severe cardiovascular diseases (arterial hypotension, decompensated chronic heart failure), a progressive disease of the spinal and brain, expressed oppression of the central nervous system, coma of any origin.
The caution is recommended Etaperazin the following events:
- Pathological changes in the hematopoietic system;
- Breast cancer;
- Angle-closure glaucoma;
- Gastric ulcer and 12 duodenal ulcer;
- Renal or hepatic impairment;
- Prostatic hyperplasia;
- Parkinson's disease;
- Reye's syndrome;
- Vomiting associated with other drugs overdose;
The drug is carried inside, after eating.
When psychotic disorders in patients not previously used antipsychotic drugs, the dosage instructions for etaperazin is 4-16 mg 2-4 times a day. The presence of chronic disease causes an increase in dose to 64 mg / day. The duration of treatment in this case is from 1-4 months.
In overdose etaperazin observed occurrence of neuroleptic reactions, for example, increased body temperature. In severe cases, impaired consciousness can manifest itself in various forms until Tuesday. Treatment of overdose by using an intravenous solution of dextrose, diazepam, nootropic medicaments, vitamins C and B, as well as symptomatic therapy.
As stated in the instructions to etaperazin for suspected intestinal obstruction and brain tumor drug use is inappropriate - as vomiting may mask the symptoms of poisoning, and hinder the diagnosis.
During treatment etaperazin recommended to monitor regularly the work of the liver and kidneys, prothrombin index, peripheral blood, and be careful when driving and employment activities that require quick response and high concentration.
The feedback to the etaperazin mentioned the need to avoid skin contact with the liquid form of the drug - to prevent the possible occurrence of contact dermatitis.
The drug is stored at a temperature no higher than 20 degrees Celsius in a dark place, away from children. Shelf life etaperazin subject to these conditions is 3 years. Use of the drug over a specified shelf life is prohibited.