Estrozhel - estrogenic agent for external use.
Pharmacological properties Estrozhelya
The composition according to instructions included Estrozhelya female sex hormone estrogen. It reduces the unpleasant symptoms that accompany menopause - attacks palpitations, flushing, increased sweating, nervousness, etc. Estrogen slows bone loss in menopause calcium. In the opinion of Estrozhel it has an effect on the body, comparable to estrogen inside.
While using the funds in the blood decreases the level of cholesterol in the liver increases the synthesis of vitamin K-dependent coagulation factors.
Estrozhel in gel form for application to the skin. Gel base evaporates from the surface and absorbed into the blood estradiol. Part of it is retained in the subcutaneous fat that provides a gradual entry into the bloodstream of small amounts of the hormone.
Because the delivery of estrogen in the body by applying Estrozhelya occurs through the skin it does not undergo transformation when passing through the liver. This allows to achieve higher blood concentrations of hormone compared with forms for oral administration.
Conversion and excretion of Estrozhelya components is the same as the natural female hormones.
According to the instructions Estrozhel produced in the form of gel for external use.
The drug used to relieve symptoms of menopause in women, including artificially induced menopause, to prevent and treat osteoporosis during menopause.
Do not use Estrozhel in the case of estrogen-dependent breast cancer, uterine, ovarian, uterine bleeding of unknown etiology, liver diseases (including Dubin-Johnson syndrome, Rotor), and acute thromboembolism, and thrombophlebitis. Contraindicated drug and pregnancy, lactation, hypersensitivity. Precautions Estrozhel used in coronary heart disease, epilepsy, asthma, severe hypertension, kidney disease.
Instructions for use Estrozhelya
Gel for application to the skin, the application mode may be continuous or cyclic. At the same time it is recommended to use progestin agents.
Before using Estrozhelya recommended gynecological examination, it should be visited at least 1 time per year during treatment.
On skin waist, abdomen, shoulder or upper arm Estrozhel applied 1 time a day in the morning or evening, in an amount of 2, 5 g (dose applicator or 2), until its complete absorption in for 2-3 minutes. If Estrozhel for 5 minutes is not sucked, then it is necessary to increase the area of application. Typically, it corresponds to a surface 1-2 palms. Apply the drug should be on clean, dry skin. Avoid getting funds to the mucous membranes of the vagina, vulva, in the mammary gland. At the time of treatment should regularly monitor blood pressure, liver function.
In the opinion of Estrozhel can cause occasional indigestion, nausea, peripheral edema, headache, breast tenderness, discharge of blood from the vagina, mood swings, irritation and redness at the site of application, change of body weight.