Espa-lipon - hepatoprotector
a drug that increases the stability of the liver to adverse factors. In addition, the effect of Espa-lipon apply to the regulation of lipid and carbohydrate metabolism in the body.
Formulations means - round biconvex tablets yellow coated and transparent solution for injection greenish-yellow shade.
Active substance-Espa Liponav tablets - thioctic acid (200 mg and 600 mg). Auxiliary components: povidone, lactose monohydrate, microcrystalline cellulose, colloidal silica, sodium carboxymethyl starch, silicon dioxide, magnesium stearate. One ampoule of injectable solution contains LIPON Espa-300 and 600 mg of active substance.
The pharmacological action of Espa-lipon
According to the instructions to the Espa-lipon, the drug has a detoxifying, hypoglycemic, hypocholesterolemic and hepatoprotective activity, taking part in the regulation of metabolism. Part of the Espa-lipon thioctic acid is involved in the oxidation reactions of alpha-keto acid and pyruvic acid, improves liver function, helps to stimulate metabolism of cholesterol.
The nature of thioctic acid similar to the B vitamins Espa-LIPON increases glycogen in liver cells, reduce blood glucose concentration, to overcome disturbances susceptibility of cells to insulin. The drug helps to eliminate toxins from the body, protects the liver cells against toxins, protects the body in cases of poisoning by salts of heavy metals.
Neuroprotective effect of Espa-lipon is to inhibit lipid peroxidation in the nervous tissue, activating blood flow endoneural, facilitating the process of nerve impulses through the cells.
The drug patients suffering motor neuropathy, according to the reviews Espa-lipon, provokes the emergence of a large number of high-energy compounds in the muscles.
When taken orally, Espa-lipon well and rapidly absorbed from the gastrointestinal tract, and the simultaneous use of funds from food reduces the speed and quality of absorption of the drug.
Metabolization thioctic acid conjugation and is accomplished by oxidation of the side chains. Displays active substance Espa-lipon in the urine as metabolites. The half-life of the drug from the blood plasma - 10-20 minutes.
Espa-lipon has the effect of "first pass" through the liver - that is, the active properties of the drug is partially reduced under the influence of a natural protector against entering the body of foreign substances.
According to the instructions Espa-lipon indicated for patients with the following conditions:
- Neuropathy (including diabetic and alcoholic etiology);
- Liver disease (including cirrhosis and chronic hepatitis);
- Chronic or acute intoxications associated with poisoning by salts of heavy metals, fungi and so forth.
Also, the drug is effective against arteriosclerosis, useful for the treatment and prevention of diseases of the arteries.
Espa-lipon not assigned to patients suffering from chronic alcohol dependence syndrome, glucose-galactose malabsorption, as well as persons with lactase deficiency in the body.
Be wary reception Espa-lipon recommended for patients with diabetes - with the obligatory dose adjustment hypoglycemic agents. Do not carry out treatment Espa-lipon children under 18 years - because of the lack of data on the safety of facilities for these patients. If there are important indications persons taking the drug in this age group can be carried out strictly according to the doctor's advice, taking into account the individual dosage.
Not proved as complete security Espa-lipon health of the fetus while taking the drug during pregnancy. If necessary, the treatment of Espa-lipon women during lactation is necessary to resolve the question of temporary weaning the baby from the breast.
Side effects Espa-lipon
According to reviews Espa-lipon well tolerated by the body, but in rare cases may cause the following side effects:
- Nausea, vomiting, headache, shortness of breath;
- Increased sweating, convulsions;
- Allergic reactions such as eczema, urticaria, haemorrhagic rash and anaphylactic shock.
peripheral polyneuropathy may feel a sense of "chills" on the skin at the beginning of therapy. With rapid intravenous drug may increase intracranial pressure, petechial hemorrhages in the skin and mucous membranes, blurred vision.
Simultaneous administration of Espa-lipon with oral hypoglycemic agents and insulin can cause increased hypoglycemic effect - increased sensitivity of peripheral tissues to insulin.
Application Espa-lipon of instructions with ethanol reduces the activity of thioctic acid. In the period of treatment is recommended to refrain from taking drugs containing ethanol, and alcoholic beverages.
In addition, the identified activity of thioctic acid for binding metals, so taking Espa-lipon simultaneously with drugs containing iron ions, calcium and magnesium, it is possible to meet a two-hour interval between doses of drugs.
Admission Espa-lipon with cisplatin reduces the effectiveness of the latter drug.
mode of application
Coated tablets are taken orally, orally, without chewing or crushing. For convenience, you can drink the medicine with plain water.
A solution for intravenous administration is prepared from the concentrate diluted in isotonic sodium chloride solution.
In diabetic polyneuropathy assigned resources 1 600 mg once a day or at 200 mg 2-3 times a day.
In severe diabetic neuropathy applied dosage of 600 mg 3 times a day.
Dose Espa-lipon and duration of treatment depends on the nature and course of the disease, as well as the personal characteristics of the patient. The optimal dose of the drug is selected exclusively by your doctor.
Reviews by Espa-lipon of overdose has been reported. When receiving the drug in far exceeding the recommended dose amounts may cause nausea, headache and vomiting. Since specific antidote Espa-lipon does not exist, the treatment of this condition is carried out symptomatically.
Attention! This guide to the Espa-lipon provided for informational purposes only. Before using the product, consult your doctor!