Enziks - it combined
drug antihypertensive action. Reviews Enzikse confirm its high therapeutic efficiency and performance.
Berlipril Koh renitek, Enalozid, enalapril, Enap - drugs Enziksa counterparts.
Structure and Composition Enziksa
The drug Enziks comes in tablet form. One pack contains two Enziksa medication - indapamide (a diuretic) and enalapril (an ACE inhibitor).
The preparation contains enalapril maleatenalaprila (active substance) and auxiliary components - magnesium stearate, magnesium carbonate, gelatin, crospovidone, lactose monohydrate.
A medicament comprising indapamide, indapamide, active ingredient and auxiliary ingredients - macrogol 6000, talc, titanium dioxide, hypromellose, with tearat magnesium, sodium lauryl sulfate, monogidrad lactose, povidone K30, crospovidone.
The instructions to Enziksu says that one-time use of enalapril and indapamide enhances mutual antihypertensive effect Enziksa.
Pharmacological action Enziksa
Action Enalapril composed Enziksa reduces the content of aldosterone by inhibiting the conversion of angiotensin first group to angiotensin second group. This reduces peripheral vascular resistance, diastolic and mean blood pressure, afterload and preload on the myocardium.
Enalapril increases coronary and renal blood flow, increases the formation of prostaglandins, has a weakly pronounced diuretic effect.
Reduction of blood pressure is not within a therapeutic effect on cerebral blood circulation. The blood flow of cerebral blood vessels due to lower performance pressure is maintained at a sufficient level.
In many reviews to Enziksu confirmed that long-term use Enalapril reduces left ventricular hypertrophy, as well as muscle cells of the artery walls resistant type by improving blood circulation, thereby preventing the progression of heart failure and inhibits the dilation of the left ventricle.
The hypotensive effect of Enalapril appears one hour after oral administration, reaching a maximum of four to six hours and lasts about a day. The half-life of the drug - 11-12 hours.
Indapamide - hypertensive drug, thiazide diuretic with a long duration and moderate in strength action of the benzamide derivatives. It reduces the tonus of the smooth muscle of arteries decreases total peripheral vascular resistance. It has a mild diuretic and salureticheskim effects that occur in the blockade of reabsorption of chloride ions, sodium, hydrogen and potassium ions in the cortical portion of the distal tubule and the proximal tubules of the nephron. Indapamide reduces left ventricular hypertrophy of the heart. In therapeutic doses has no effect on carbohydrate and lipid metabolism. The antihypertensive effect reaches its peak a week with regular medications and maintained throughout the day in the case of a single dose. The maximum concentration of indapamide plasma achieved in one to two hours after ingestion. The half-life of indapamide - 14-16 hours.
According to the instructions Enziks recommended to take with hypertension.
Enziks - Instructions for use
According to the instructions to Enziksu one tablet of indapamide and Enalapril one tablet should be taken at the same time once a day.
Depending on changes in blood pressure Enalapril dose may be increased up to two times per day.
Contraindications Enziksa considered on the basis of contraindications two drugs that make it - enalapril and indapamide.
Contraindications to the use of indapamide:
- severe renal and / or hepatic impairment;
- childhood and adolescence to 18 years;
- hypersensitivity to indapamide;
With care use in patients with diabetes and giperrurikemii.
Contraindications to the use Enalapril:
- renal insufficiency;
- angioedema in history;
- giperchuvstvitelnostk enalapril;
- childhood and adolescence to 18 years;
assign elderly patients and patients with the following diseases:
- liver and / or renal failure;
- cerebrovascular diseases;
- coronary artery disease;
- systemic connective tissue diseases;
- mitral stenosis;
- aortic stenosis and idiopathic hypertrophic subaortic stenosis;
- primary hyperaldosteronism.
Side effects of the drug Enziks
Judging by the reviews to Enziksu, the drug long-term use often causes nausea, dry mouth, tinnitus, impaired vision and hearing, gastralgia, diarrhea or constipation, allergic reactions, palpitations, decreased libido, insomnia, water and electrolyte disturbances, depression , dizziness, headache.
The instructions to Enziksu said that very rarely prolonged use of the drug leads to the development of myocardial infarction, cough, pharyngitis, sinusitis, muscle cramps, and contributes to the emergence of drowsiness, general weakness, malaise, fatigue.
One-time use of enalapril and NSAIDs, analgesics, antipyretics reduces the effectiveness of the drug.
The antihypertensive effect of Enalapril increase beta-blockers, diuretics, nitrates, hydralazine and prazosin.
The combined use of enalapril and potassium-sparing diuretics (amiloride, spironolactone, triamterene), as well as potassium-containing agents increases the risk of hyperkalemia.
Enalapril reduces the effect teofillinsoderzhaschih drugs. Immunosuppressive agents enhance the haematotoxicity.
The combined use of indapamide and saluretics, cardiac glycosides, glucose and mineralocorticoid, tetrakozaktidom, laxatives increase the risk of hypokalemia.
Indapamide helps to increase the concentration of lithium in the blood plasma.
Baclofen enhances the hypotensive effect of indapamide.
One-time use of ACE inhibitors and indapamide often leads to the development of arterial hypotension.
The combined use of indapamide and iodine preparations in high doses increases the risk of kidney failure.
Antipsychotic drugs and tricyclic antidepressants increase the hypotensive effect of indapamide.
Storage conditions Enziksa
According to the instructions Enziks should be stored in a dry place at a temperature of 20 ° to 25 ° C.
Shelf life - 3 years.