Enterofuril - the medicament from the group of antimicrobials broad spectrum.
The drug has no systemic effect, prescribed for the treatment of infectious diarrhea. The active ingredient - nifuroxazide, the 5-nitrofuran. Enterofuril has a bactericidal, bacteriostatic action, is active against many pathogens of the gastrointestinal tract. The antimicrobial effect of the drug is dose-dependent, with low, medium doses have bacteriostatic action, high - bactericidal.
Bacteriostatic effect associated with inhibition Enterofuril dehydrogenase activity, this violates the biosynthesis of compounds necessary in the bacterial cell. As a result of the respiratory chain is blocked, inhibited citric acid cycle, and bacterial cells lose their ability to reproduce.
Enterofuril bactericidal action due to the ability of high doses of the drug destructive effect on the cell membrane of bacteria. As a result, compromising the integrity of the cell membrane of bacteria death occurs.
Enterofuril also able to inhibit the production of exotoxins pathogenic bacteria, thereby reducing the irritation of intestinal epithelial cells and reduced production of fluid into the lumen of the gastrointestinal tract.
Due to the increase in phagocytic activity Enterofuril activates the immune system.
The drug has no inhibitory action against non-pathogenic flora, in connection with its use arises dysbacteriosis.
After oral administration Enterofuril not absorbed in the gastrointestinal tract, there is no systemic effect. In the intestine, a high concentration of the drug. Enterofuril excreted in the feces.
Due to the high clinical efficacy Enterofurile positive reviews. In addition to good effect in the gastrointestinal tract bacterial infections, the drug also reduces the risk of bacterial superinfection during viral diarrhea, so when this disease is also advisable Enterofuril appointment.
According to the instructions Enterofurilu, testimony to his appointment are:
- acute, chronic diarrhea of bacterial etiology (with signs of helminth invasion Enterofuril does not apply);
- chronic diarrhea in colitis;
- iatrogenic diarrhea caused by the appointment of antimicrobial agents;
- on the testimony may be given Enterofuril diarrhea unspecified etiology.
According to the instructions Enterofurilu, the drug is contraindicated in case of hypersensitivity to the nifuroxazide or other derivatives of nitrofurans in childhood (up to 1 month). The drug is not used to treat premature infants, in capsule form - before the age of 7 years.
Dosing Enterofuril, dosage
For patients older than 7 years Enterofuril applied in the form of capsules and suspensions. Up to 7 years is recommended to use suspension Enterofuril. The duration of therapy, as well as the dosage in a particular clinical situation determined by the physician.
Enterofuril dosage for adult patients is 200 mg (contained in one scoop) four times a day. The maximum daily dosage of 800 mg. The recommended course of treatment is 7 days.
Patients aged 2-7 years, the dosage is 200 mg (spoonful) three times a day. The maximum daily dose - 600 mg. Duration of treatment - no more than a week.
Patients aged 7 months - 2 years, the dosage is 100 mg (contained in half measuring spoon) three times a day. The maximum daily dose - 400 mg. The duration of Enterofuril should not exceed 7 days.
In children between 1 and 7 months, the dosage is 100 mg twice daily.
Enterofuril applies regardless of the diet. The capsule should be swallowed whole, washed down with plenty of water. Not recommended to divide the capsule. The suspension must be shaken thoroughly before use. For convenience, we recommend using the supplied measuring spoon.
The drug is usually quite well tolerated, as evidenced by reviews Enterofurile from patients. In rare cases, it noted the appearance of allergic reactions such as urticaria.
Application Enterofuril during pregnancy
On strict Enterofuril it can be assigned during pregnancy, but only in situations where the expected benefit to the mother's organism is much higher than the potential risk to the fetus. Information about the negative impact on the fetus Enterofuril no. Enterofuril penetrates into breast milk can therefore be administered during lactation.
Interaction with other drugs Enterofuril
Due to lack of absorption is unlikely Enterofuril interaction with other drugs. However, it is recommended to use the drug with ethanol containing drugs. Do not use Enterofuril simultaneously with sorbents, in which case its effectiveness is reduced.
Information about overdose Enterofuril not. If you accidentally taking very high doses of non-specific therapy is recommended: a gastric lavage, oral chelators.
Efficiency Enterofuril and analogs proved in many clinical trials. The drug is well established in the treatment of infectious diseases gastrointestinal tract, so Enterofurile positive reviews. The preparation is relatively safe, in most cases, well tolerated.
Recommended Enterofuril stored at room temperature.
Currently, registered the following analogues Enterofuril: nifuroxazide, ersefuril, Ekofuril, Lekor.
The drug Enterofuril can only be used for its intended purpose of the attending physician.
Before using the product you must read the instructions for Enterofurilu.