Doxorubicin

 Doxorubicin
 Doxorubicin - an anti-tumor antibiotic.

Pharmacological action

Doxorubicin - is an antibacterial drug from a number of anthracyclines. He opposes proliferation (tissue growth by cell proliferation), slows down the excessive cell division.

Pharmacological effects of doxorubicin is its interaction with DNA in the direct action on the cell membranes, formation of free radicals.

Product form

Doxorubicin discharged as a concentrate and a solution for preparing a lyophilisate for intravenous administration.

Indications Doxorubicin

Doxorubicin according to the instructions prescribed for: certain types of sarcoma (Ewing, osteosarcoma, soft tissue sarcoma), breast cancer, small cell lung cancer, malignant thymoma, cancer of the esophagus, stomach, pancreas, primary hepatocellular, bladder, ovarian, endometrial, cervical, , prostate gland, adrenal glands, hepatoblastoma, carcinoid tumors, testicular germ cell, trophoblastic tumors, tumors Williams, neuroblastoma, acute lymphoblastic and myeloid leukemia, chronic lymphocytic leukemia, multiple myeloma, lymphoma nehodzhikinskoy, chlamydia, retinoblastoma.

Also, there are good reviews of doxorubicin used in AIDS.

Contraindications

Doxorubicin is contraindicated in cases of anemia, myocarditis, acute myocardial infarction, leukopenia, acute hepatitis, thrombocytopenia, peptic ulcer, duodenal ulcer and stomach, tuberculosis, pregnancy, disorders of the kidney, liver, bilirubinemia.

Instructions for use Doxorubicin

Doxorubicin is administered intravenously only dissolving beforehand in an isotonic solution.

The appointment means the doctor spends profile based on the patient's age, his general condition, especially the disease. The manual contains Doxorubicin such a common treatment regimen: one square meter of body surface administered 50-65mg of the drug. Introduction repeated after 21 days.

Doxorubicin smaller dosages prescribed to patients, in which lack of bone marrow reserves - because of advanced age, neoplastic infiltration therapy or bone marrow.

 Doxorubicin - lyophilisates for solution
 Use the can and other treatment regimen in which one square meter of body surface area administered 20-30mg every day - for three days, every three to four weeks. You can enter once a week 30 mg per square meter and for 3-4ned. The break between the therapeutic course - 3-4ned.

Acceptable dose of the drug when administered intravenously regardless of the chosen scheme - 550mg / m.

Side effects

The most serious side effects of doxorubicin, because it is necessary to limit the dose - myelosuppressive effect (suppression of hematopoietic function of the bone marrow) and cardiotoxicity.

In addition, there are reviews of doxorubicin, that it causes a reversible alopecia, hypersensitivity reactions, flushing of the skin over the vein with the rapid introduction, fleboskleroz, vomiting, anorexia, nausea.

Necrosis of surrounding tissue may occur if the solution runs out of Doxorubicin vessels.





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