Disulfiram

Disulfiram - for the treatment of alcoholism.

Pharmacological action

 Disulfiram - tablets for oral use
 Disulfiram, impacting the decomposition of ethanol, which is ingested, causes human toxic response to alcohol, which leads to the formation of a stable reflex and appearance of aversion to products containing alcohol and not only to their taste, but their smell and sight .

Application Disulfiram causes after alcohol intake in humans begins vomiting, dizziness, reduced pressure, there is a general weakness, feeling of fear.

Product form

The tablets, capsules and gel implant tablets for oral use, a solution for intravenous administration of disulfiram.

Indications

Disulfiram according to the instructions indicated for the prevention, treatment of alcoholism, chronic poisoning with nickel.

Disulfiram Guide: how to use

Disulfiram administered intravenously, subcutaneously, taken orally.

Tablets are taken in a dosage of 0, 25-0, 5 grams per day.

Disulfiram is administered intravenously, on average, at a dosage of 0, 25-0, 5 grams per day.

Good reviews of disulfiram that subcutaneously sewn - it can be a capsule, gel or tablets. Implants sewn into areas of the body where there is fatty tissue - hips, shoulder blades, buttocks or abdomen. You can sew 5-8 Disulfiram tablets or capsules 1-2.

Dosages are average, in most cases the appointment of a doctor spends on an individual basis.

Great effect, judging by the reviews of disulfiram can be achieved only when the patient really wants to recover from alcohol dependence.

Side effects Disulfiram

After drugs Disulfiram may occur taste of metal in mouth, confusion, hepatitis, polyneuritis feet, memory loss, skin allergies, headache, optic neuritis.  Disulfiram - tablets for implantation

There are reviews of disulfiram, which is due to the combination with ethanol causes the development of respiratory failure, cardiac arrhythmias, angina pectoris, heart attack, cardiovascular collapse, neurological disorders, coma, cerebral edema.

If, during treatment, the patient will drink more than 50-80 ml of vodka, it may be severe pathology of the cardiovascular and respiratory system activity, swelling, seizures can begin.

Against the background of long-term therapy may experience psychosis, gastritis, hepatitis, exacerbation of polyneuritis. It may also develop a brain thrombosis (more common in patients suffering from cardiovascular disease), so the numbness of the hands, feet or face should stop taking Disulfiram.

Contraindications

Disulfiram is contraindicated in decompensated forms of cardiovascular disease, thyrotoxicosis, neuritis of the auditory or visual nerve, glaucoma, diabetes, tuberculosis, bronchial asthma, emphysema, an exacerbation of ulcer, severe liver disease, kidney disease, malignant neoplasms of the hematopoietic system, mental illness, seizures of any origin, epilepsy, during lactation, pregnancy.

During medical treatment consider that the response to ethanol reduces vitamin C; isoniazid in combination with a preparation of disulfiram causes incoordination and behavior; tinidazole, ornidazole, metronidazole, seknidazol while the use of the drug causes confusion and delirious disorders.

According to the instructions Disulfiram with caution combine with warfarin, because there is a risk of bleeding opening, with theophylline, as its metabolism is suppressed, with benzodiazepines, as sedation may occur, tricyclic antidepressants, as may increase the reaction of ethyl alcohol intolerance.





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