It has sedative and anxiolytic effects, manifested in the removal of stress, anxiety, fear. Reviews of diazepam as a hypnotic talk about its high efficiency, but after receiving some confusion may occur after sleep. Has the ability to muscle relaxation, it produces anticonvulsant effect, reduces the symptoms of alcohol and drug withdrawal, but by sharing a enhances the effect of alcohol and drugs. It causes amnesic effect, increases the pain threshold, has antiarrhythmic activity, lowers blood pressure, but can also increase intraocular pressure. Long term use of Diazepam is addictive.
Diazepam Guide recommends taking it as a sedative in the following cases:
All kinds of neuroses and neurosis-like disorders: panic attacks, anxiety disorders, obsessive-compulsive disorder, accompanied by increased physical and emotional activity, phobias, pathological condition caused by excessive psycho-emotional tension, anxiety syndrome, prolonged sleeplessness;
In the combined therapy in the treatment of delirium tremens, as well as to relieve the acute symptoms of alcohol and drug withdrawal;
In the combined therapy in the treatment of schizophrenia and other mental disorders (reactive psychosis, psychopathy various etiologies, paranoid state, etc.);
Relief of epileptic seizures and epileptopodobnyh;
In anesthesiology Diazepam is recommended as premedication before surgery, thus reducing the dosage of the narcotic drug, as well as to relieve stress and fear before any medical procedures in patients with labile mentality;
The treatment of angina, hypertension, myocardial infarction and post-infarction states;
In the combined therapy in the treatment of skin diseases associated with increased sensitivity of the skin and itching;
Physician reviews of diazepam suggests it as an effective tool in the treatment of all types of spastic disorders, including traumatic, neurological and inflammatory disorders, as well as those related to the central nervous system, the drug effectively relieves spasms of skeletal muscles in arthritis, arthrosis , myositis, spondylitis;
In pediatric practice Diazepam is recommended for behavioral disorders involving excessive activity, emotional stress, fear, sleep disturbances, increased aggression in the complex therapy in the treatment of enuresis.
Instructions for use Diazepam
Effect after administration occurs within 1-2 minutes after intravenous administration, 30-40 minutes after intramuscular administration, 40 minutes - 1 hour after oral administration or intrarectal. The dosage is calculated individually for each patient, taking into account the clinical manifestations of the disease, age and body of the patient, as well as individual susceptibility.
When using diazepam as sedative daily dose may vary from 5 to 40 mg, divided into 2-4 reception. If necessary, the prolonged use of diazepam start with small doses, increasing to pick the optimal well tolerated by the patient the dosage. If the daily dose is divided into several stages, it is desirable that evening was the largest.
The instructions to diazepam particularly drawn attention to the fact that the intravenous administration of the drug needed to do this slowly, no faster than 1 ml in 1 min. When long-term therapy should not be abruptly interrupt taking the drug because of the risk of withdrawal symptoms.
When properly selected dosage elevated individual sensitivity and the interaction with other drugs diazepam and its analogs also can have the following side effects:
Reduced ability to concentrate, lack of coordination, disorientation, dizziness, confusion until, in severe cases;
Lethargy, weakness, fatigue;
Depressed mood, blunted emotions, sometimes emotional lability, tearfulness, rare outbreak of unmotivated aggression or depression;
Hallucinations, increased anxiety, worsening of suicidal tendencies (rare);
Memory impairment, symptoms of anterograde amnesia;
Movement disorders: tremor of limbs, uncontrolled movements (tics);
Decreased libido or excessive it increase;
Inhibition of blood: anemia, leukopenia, neutropenia, thrombocytopenia, agranulocytosis;
Tachycardia, excessive reduction of blood pressure, shortness of breath, pain in the heart;
Disorders of the kidneys and urinary tract, urinary incontinence;
Dyspepsia: nausea, vomiting, heartburn, constipation, appetite changes in one direction or another, sometimes significant - up to the development of bulimia or anorexia;
Blurred vision (diplopia);
The preparation with an impressive list of side effects, of course, has no contraindications. Diazepam and analogues are contraindicated in the following conditions: acute diseases of the excretory system (liver, kidney), cardiovascular system in the stage of decompensation, glaucoma, pregnancy (teratogenic effect has!), Suicidal tendencies, sleep apnea, breast-feeding, spinal ataxia, hypercapnia, increased individual sensitivity to peers Diazepam history, early childhood), alcohol / drug abuse.
The instructions to diazepam indicates that self-administration of the drug in any of its formulations are categorically unacceptable, particularly the hazards of improper use of it in a pediatric practice, taking strictly on prescription.
Store away from direct sunlight, dry place at room temperature (19-23 ° C). Diazepam and analogues should be stored in a completely inaccessible to children.