Cymbalta - pharmacological agents from the group of antidepressants.
Structure and Composition
According to the instructions Cymbalta comes in a capsule form for oral administration. The active ingredient - duloxetine. In one capsule preparation contains 30 or 60 mg of duloxetine and auxiliary components (sucrose, talc, hypromellose, hypromellose acetate succinate, white colorant, triethyl citrate, titanium dioxide, sodium lauryl sulfate, gelatin, iron oxide yellow dye).
Cymbalta capsules made from 30 and 60 mg. The blister pack 7 or 14 capsules with the drug. The carton can be 1, 2 or 6 blisters.
The pharmacological action of the drug Cymbalta
According to the instructions Cymbalta belongs to the group of antidepressants. The drug inhibits the reuptake of serotonin and norepinephrine, resulting in increased noradrenergic and serotonergic neurotransmission in the central nervous system. Besides the drug contributes to the suppression of pain, thereby increasing pain threshold in patients with pain of neuropathic origin.
Cymbalta is well absorbed after oral administration. The maximum drug concentration in serum is determined after 6 hours after ingestion. In the body of duloxetine is metabolized. Cymbalta withdrawal of the drug in the kidneys. The half-life of 12 hours.
According to the instructions recommended to prescribe Cymbalta for depression and painful form of diabetic neuropathy.
- hypersensitivity to the ingredients;
- angle-closure glaucoma (uncompensated);
- simultaneous MAO inhibitors (monoamine oxidase).
Precautions This drug should be used during exacerbation of mania, seizures, liver dysfunction / renal, mydriasis, as well as in patients with a tendency to suicide.
Use during pregnancy and lactation
According to the instructions Cymbalta is not recommended during pregnancy, as there is not enough clinical experience with this drug.
Use of Cymbalta advisable only when the potential benefits of the drug significantly higher risk to the fetus.
During the period of lactation should not use this drug.
Dosage and administration of the drug Cymbalta
The capsules of the drug taken by mouth, as a whole, without chewing.
Cymbalta initial dose is typically 60 mg once a day, regardless of the meal. The maximum dose - 120 mg (in two steps). In the opinion of Cymbalta was well tolerated and effectively helps with depression.
Patients with symptoms of renal failure, the recommended starting dose is 30 mg.
There is no clinical experience with Cymbalta in patients younger than 18 years.
According to reviews Cymbalta rarely causes side effects. In clinical studies, the most common side effects include the following: dizziness, dry mouth, insomnia, headache (10%). It should be noted that in patients receiving placebo headache occurred more frequently than in the employment drug Cymbalta.
Very rarely (1 to 10%), reviews, Cymbalta cause side effects such as diarrhea, tremor, decrease of appetite, weakness, sweating, hot flushes, anorgasmia, decreased libido, ejaculation disorders.
In patients with diabetic neuropathy Cymbalta may cause a slight increase in the concentration of glucose in the blood.
There are few reports of overdose with this drug, there were no fatal consequences. Symptoms of overdose may include: tremors, convulsions, ataxia, vomiting. Treatment is symptomatic. No specific antidote.
Interaction with other drugs
Should not simultaneously take drugs with similar effects on the central nervous system (including ethanol).
Cymbalta and combination of drugs that are highly bound to plasma proteins can cause an increase in the concentrations of both drugs.
Specific guidance on the use of Cymbalta
Do not take the drug at the same time Cymbalta and MAOIs, as described isolated cases of fatal and serious complications (myoclonus, hyperthermia, expressed excitement with the transition into a coma). Do not use this medication within 14 days after MAO inhibitor therapy.
In patients with manic states the use of other drugs that affect the nervous system (or alcohol) in combination with Cymbalta may increase the disease.
Since depression is likely suicide attempts, it is necessary to carefully monitor patients who are at risk.
Admission Cymbalta may cause drowsiness, so patients taking the drug, you need to exercise caution when driving and when working with moving machinery.