Cordarone - cardiovascular agent.
Pharmacological action cordarone
Cordarone is an antiarrhythmic drug 3rd class, eliminating the arrhythmia and angina.
Cordarone blocks adrenergic receptors, reduces the conductivity sinoatrialnuyu atrial node and not affecting the conductivity of intraventricular. The drug reduces miokardnuyu excitability, increases the refractory period.
Effective treatment of angina pectoris due to a decrease in myocardial oxygen consumption (by decreasing total peripheral vascular resistance and heart rate), the increase in coronary blood flow (due to direct effects on the muscles of the arteries), the maintenance of cardiac output (due to the decrease of pressure in the aorta and peripheral resistance).
After intravenous administration of Cordarone miokardnaya reduced contractility, significant negative inotropic effect is not present.
Reviews of Cordarone indicate that the drug reaches maximum activity after 15min. after administration and passing through 4h.
Producing Cordarone tablets, solution.
Cordarone prescribed to stop the attacks of paroxysmal tachycardia, ventricular tachycardia, and paroxysmal supraventricular (high ventricular rate), to eliminate a stable and paroxysmal atrial fibrillation, atrial flutter.
Also according to the instructions Cordarone prescribed for the prevention of recurrence of atrial fibrillation in heart ventricles, ventricular arrhythmias, paroxysmal supraventricular tachycardia, atrial fibrillation, atrial flutter.
Good reviews of Cordarone, is used to treat patients with heart disease of organic origin, accompanied by left ventricular dysfunction.
Instructions for use cordarone
Cordarone Tablets for instructions used in various configurations:
- Outpatient treatment is initiated with 600-800mg / day, taken in divided doses. Once the total amount received will be brought to the Cordarone 10g (usually 10-14dn), the patient is transferred to the maintenance dose, hoping to 3mg per kg (100-400mg / day).
- Inpatient treatment also begins with 600-800mg / day (maximum - 1200mg), adjusted for 5-8dn do10gr.
In cordarone significant half-life, it is allowed to take every 2nd day, with a dose of 100 mg is recommended to be taken every day, and 200mg - every second. During treatment, you can take a break - two days / week.
astvor Cordarone used for intravenous infusions or injections. For loading of the infusion dosage for an adult is 5 mg per kilogram body weight. Cordarone is dissolved in 250 ml of 5% glucose. Infusion may be carried out from 20 minutes to 2 hours. Introduction repeated two or three times during the day. It usually takes a maintenance infusion, because effect of the drug gradually decreases. For maintenance of the therapeutic effect is administered to adults for several days 10-20mg per kg body weight per day (about 600-800mg per day, maximum - 1200mg). This dosage is also diluted in 250 ml 5% glucose.
The recommended dose for adults for injection - 5 mg per kilogram of Cordarone is introduced it for three minutes. The next injection can be carried out only after 15min. If you want to continue treatment, switching to infusion administration.
Children after three years Cordarone administered in a dosage of 5 mg per kilogram.
Mixing the drug with other drugs in the same syringe should not be.
Application Cordarone may cause the deposition of lipofuscin in the corneal epithelium, photosensitivity, hypothyroidism, hyperthyroidism, bradycardia, hypotension, a decrease in conductivity AV, alveolitis, pneumonia, nausea, abnormal liver function, severity of epigastric.
There are individual reviews of Cordarone, causes the development of peripheral neuropathy, tremor.
Parenteral administration of Cordarone can cause fever, sweating, sleep apnea, bronchospasm, phlebitis, increased intracranial pressure.
The instructions Cordarone stated that the tablet can not assign intolerance amiodarone, iodine, the weakness of the sinus node, intraventricular conduction disorders, atrioventricular, thyroid gland dysfunction, heart failure, hypokalemia, interstitial lung disease.
Also Cordarone tablets is contraindicated in women pregnant, breastfeeding, children up to 18L.
Do not prescribe pills together with drugs causing ventricular tachycardia poliformnuyu "pirouette" with MAO inhibitors.
You can not enter Cordarone IV allergy to amiodarone, iodine, with sinus bradycardia, sinoatrial heart block, sinus node weakness, severe conduction disorders (without pacemaker), dysfunction of the thyroid gland.
It is impossible to carry out intravenous cordarone simultaneously with the means of causing ventricular tachycardia paroxysmal.
Intravenous Cordarone is contraindicated in nursing women, children under three years. Pregnant women drug is administered in exceptional cases.