Clindamycin

 Clindamycin pills
 Clindamycin - a broad spectrum antibiotic, available in a variety of dosage forms for the treatment of infectious diseases. Widely used in pediatrics.

Pharmacological action

Clindamycin relates to antibiotics, lincosamides.

The active substance has a bacteriostatic effect when used in therapeutic doses, while in higher doses - bactericidal against strains sensitive to clindamycin. Clindamycin is widely used, including pediatric at various respiratory diseases, soft tissues, bones and joints, caused by:

  • Propionibacterium;
  • Eubacterium;
  • Corynebacterium diphtheriae;
  • Peptococcus;
  • Clostrtidium tetani;
  • Clostrtidium perfringens;
  • Veillonella;
  • Staphylococcus spp .;
  • Fusobacterium spp. (Except F.varium, which is resistant);
  • Streptococcus spp .;
  • Bacteroides spp;
  • Bacillus anthracis;
  • Peptostreptococcus spp ..

According to the instructions of clindamycin resistant most gram-negative aerobic bacteria, resistant strains of Staphylococcus aureus, Neisseria gonorrhoeae, Haemophilus influenzae and Neisseria meningitidis, as well as viruses, fungi (including yeast).

Product form

Clindamycin is produced in the form:

  • Gelatin capsules violet housing containing white powder on 0, 075 g (for children), 0, 3 and 0 g, 15 g clindamycin hydrochloride. 8 pieces in a blister;
  • Transparent colorless 15% solution for intravenous injection, 150 mg of active ingredient in 1 ml. The ampoules of 2 ml, 4 ml, and 6 ml;
  • Flavored granules for syrup for children Clindamycin containing 75 mg of active ingredient in 5 ml. In bottles of 80 ml;
  • 2% Clindamycin vaginal cream in tubes of 40 g of 7 one-time applicators;
  • White, cylindrical-shaped candle Clindamycin vaginal suppositories 3 in the package;
  • Uniform white Clindamycin gel for topical application in aluminum tubes of 15 g

Indications Klindatsimina

According to the instructions Clindamycin is used for:

  • Peritonitis;
  • Osteomyelitis;
  • Empyema;
  • Endometrium;
  • Adnexitis;
  • Purulent infections of the skin and soft tissues;
  • Lung abscess;
  • Pneumonia;
  • Festering wounds.

Clindamycin is also used in a combination therapy for the prevention of peritonitis and intra-abdominal abscesses.

Clindamycin Gel is used externally in the treatment of acne.

Candles Clindamycin is used locally for vaginosis, caused by sensitive microorganisms.

Contraindications

According to the instructions Clindamycin is contraindicated in:

  • Hypersensitivity to lincomycin or clindamycin;
  • Severe liver or kidney disease;
  • Myasthenia gravis;
  • Bronchial asthma;
  • Ulcerative colitis.

Clindamycin is not appointed to the age of the month and the elderly, is prescribed with caution in diseases of the gastrointestinal tract in history.

Clindamycin is contraindicated during pregnancy and lactation for both oral and parenteral administration.

Vaginal clindamycin possible only under strict indications.

Instructions for use Clindamycin

 Clindamycin cream
 The dose of clindamycin and its selection depends on the dosage form of the disease, the disease and age.

In severe infections and diseases of the abdominal cavity Clindamycin is used according to instructions in the form of injections. In milder forms usually administered in 1 day, 2-1, 8 g, and in severe - 2, 4-2, 7 grams divided by the reception 2-4. Simultaneously, do not enter more than 600 mg of clindamycin.

Clindamycin intravenous drip used in inflammation of the uterus and the peritoneum, which is localized in the pelvic area, every 8 hours to 0, 9 g intravenous Clindamycin is used for at least four days, and then at least two days after the onset of improvement.

Tablets Clindamycin used after the clinical effect, every 6 hours for 450 mg to complete a two-week course of therapy.

For the treatment of mild to moderate severity of infectious and inflammatory diseases is also used pills Clindamycin. Adults appoint every 6 hours at 150-450 mg for at least 10 days.

For the treatment of infections of the cervix, which cause chlamydia used pills Clindamycin 4 times daily 450 mg over 10-14 days.

The most commonly used Pediatrics Clindamycin syrup, for which a vial of beads was added 60 ml of water. Dose is calculated from the weight and age of the child. The daily dose for children of 8-25 months is 1 mg per kg body weight, divided into 3-4 hours. Children weighing up to 10 kg and less than half a teaspoon administered three times a day. Tablets can be applied with Clindamycin 8 years weighs at least 25 kg.

When inflammation of the vagina caused by bacteria susceptible to the drug, prescribed Clindamycin vaginal cream. One full applicator - a single dose is administered before bedtime in the vagina. The course of treatment - at least a week.

Clindamycin Gel is used externally for acne, putting on the affected area several times a day. The course of treatment is two weeks to a month.

Candles Klindatsin intended for the treatment of urinary tract infections and prevention of vaginal inflammation, and it is used during the preparation of various gynecological surgery. Usually treatment candles Clindamycin is three days, one suppository daily.

Candles Clindamycin should not be used concurrently with other vaginal medications, as well as calcium gluconate, ampicillin, erythromycin and barbiturates. Clindamycin while the use of drugs that block neuromuscular transmission, increases their effect.

Side effects

Clindamycin cause various side effects.

After intravenous application may appear metallic taste, phlebitis, abscess. After taking the pills Clindamycin - phenomenon esophagitis, abdominal pain, diarrhea, liver disease and jaundice.

Suffice it may rarely cause urticaria, reversible leukopenia, fever, angioedema, neutropenia, thrombocytopenia, agranulocytosis, lowering blood pressure, weakness.

When using candles Clindamycin - vaginitis, cervicitis, or vulvovaginal irritation, and in the application of clindamycin cream - minor allergic skin reactions.

Storage conditions

Clindamycin related to drug B group and released on the doctor's prescription.





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